Amin Ebadi
Department of Chemistry, Kazerun Branch, Islamic Azad University, Kazerun, Iran.
[ 1 ] - QSAR Study of 17β-HSD3 Inhibitors by Genetic Algorithm-Support Vector Machine as a Target Receptor for the Treatment of Prostate Cancer
The 17β-HSD3 enzyme plays a key role in treatment of prostate cancer and small inhibitorscan be used to efficiently target it. In the present study, the multiple linear regression (MLR),and support vector machine (SVM) methods were used to interpret the chemical structuralfunctionality against the inhibition activity of some 17β-HSD3inhibitors. Chemical structuralinformation were described thro...
[ 2 ] - QSAR Study of 17β-HSD3 Inhibitors by Genetic Algorithm-Support Vector Machine as a Target Receptor for the Treatment of Prostate Cancer
The 17β-HSD3 enzyme plays a key role in treatment of prostate cancer and small inhibitorscan be used to efficiently target it. In the present study, the multiple linear regression (MLR),and support vector machine (SVM) methods were used to interpret the chemical structuralfunctionality against the inhibition activity of some 17β-HSD3inhibitors. Chemical structuralinformation were described thro...
[ 3 ] - مطالعه ارتباط کمّی ساختار- فعالیت برای پیش بینی فعالیت مهارکنندگی PIM مشتق‌های تری آزولوپیریدین با استفاده از الگوریتم ژنتیک ـ برازش خطی چندگانه
مطالعه ارتباط کمی ساختار ـ فعالیت (QSAR) برای مدل سازی و پیش بینی فعالیت مهارکنندگی PIM،39 ترکیب از مشتق های تری آزولوپیریدین به کار گرفته شد. نخست پس از رسم و بهینه سازی ساختار ترکیب ها و محاسبه توصیف کننده ها، مجموعه داده ها به صورت تصادفی به دو مجموعه آموزش و آزمون تقسیم شد. در انتخاب مهمترین توصیف کننده ها روش گام به گام (SW)<e...
Co-Authors