Naser Amirizadeh

[ 1 ] - CDKN2B methylation correlates with survival in AML patients

Aberrant DNA methylation has been reported as an important phenotype in acute myeloid leukemia. However the clinical significance of methylation changes has not been clear yet. In this study methylation Specific Melting Curve Analysis (MS-MCA) and real time PCR was used to assess the CDKN2B promoter hyper-methylation and gene expression in 59 Iranian acute myeloid leukemia (AML) patients. The i...

[ 2 ] - CDKN2B methylation correlates with survival in AML patients

Aberrant DNA methylation has been reported as an important phenotype in acute myeloid leukemia. However the clinical significance of methylation changes has not been clear yet. In this study methylation Specific Melting Curve Analysis (MS-MCA) and real time PCR was used to assess the CDKN2B promoter hyper-methylation and gene expression in 59 Iranian acute myeloid leukemia (AML) patients. The i...

[ 3 ] - فراوانی آلل‌های D ضعیف در اهداکنندگان خون با روش‌های مولکولی

چکیده سابقه و هدف از آن جایی که شناسایی آنتی‌ژن‌های D ضعیف می‌تواند از مصرف بی جای خون RhD منفی و تزریق نا به جای رگام در مادران جلوگیری نماید، تعیین فراوانی انواع آلل های D ضعیف در کشور ما ضروری به نظر می‌رسد. در این مطالعه فراوانی این آلل‌ها در بین اهداکنندگان خون 21 استان ایران در سال 1395 از طریق آنالیز مولکولی بررسی گردید. مواد و روش‌ها مطالعه انجام شده از نوع توصیفی بود. تعداد 105 نمونه...

[ 4 ] - Gene Expression and Methylation Pattern in HRK Apoptotic Gene in Myelodysplastic Syndrome

Myelodysplastic syndromes (MDSs) are a clonal bone marrow (BM) disease characterized by ineffective hematopoiesis, dysplastic maturation and progression to acute myeloid leukemia (AML). Methylation silencing of HRK has been found in several human malignancies. In this study, we explored the association of HRK methylation status with its expression, clinical parameters and MDS subtypes in MDS pa...

[ 5 ] - Investigation of Paternal RhD Zygosity by Two Molecular Methods among Blood Donors in Kurdistan Province, Iran

Background: RhD antigen system is the leading cause of hemolytic disease of the fetus and newborn (HDFN). Paternal molecular RhD zygosity test is valuable to decide on the use of anti-D immunoglobulin prophylaxis in Rh D-negative pregnant women. We aimed to investigate the paternal RhD zygosity by two molecular methods among blood donors in Kurdistan province, the west of Iran. We also compared...