Mozafar Khazaei
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
[ 1 ] - Synergistic Anticancer Effect of Paclitaxel and Noscapine on Human Prostate Cancer Cell Lines
Paclitaxel is the one of the most common chemotherapeutic drugs used for the treatment of prostate cancer. However, its current clinical utility has been limited due to numerous serious side effects and drug resistance. Noscapine is an antitussive opium alkaloid that showed antitumor activity against a variety of cancer while has not exhibited severe side effects. This study investigates the a...
[ 2 ] - Synergistic Anticancer Effect of Paclitaxel and Noscapine on Human Prostate Cancer Cell Lines
Paclitaxel is the one of the most common chemotherapeutic drugs used for the treatment of prostate cancer. However, its current clinical utility has been limited due to numerous serious side effects and drug resistance. Noscapine is an antitussive opium alkaloid that showed antitumor activity against a variety of cancer while has not exhibited severe side effects. This study investigates the a...
[ 3 ] - بررسی اثر حفاظتی عصاره هیدروالکلی گیاه غازیاقی Falcaria vulgaris بر زخم معده ناشی از آﺳپرین درموش صحرائی
چکیده زمینه و هدف: در طب سنتی غرب کشور گیاه غازیاقی (Falcaria vulgaris) مصارف گوناگونی از جمله درمان زخمهای پوستی و زخم معده دارد. این گیاه اثرات قابل توجهی در حفاظت معده در مقابل ضایعات ناشی از اتانول نشان داده است. هدف مطالعه حاضر، بررسی اثر حفاظتی عصاره هیدرو الکلی غازیاقی بر زخم معده ناشی از آﺳپرین در موش صحرائی میباشد. روش بررسی: 24 عدد موش صحرائی جوان از نژاد NMRI، با وزن 230-180 گرم، ...
[ 4 ] - نقش نیتریک اکسید در سیستم های بیولوژیک بدن: یک مرور سیستماتیک
Nitric oxide (NO) is known as an unstable signaling molecule that can be produced by three different NO synthase (NOS) isoforms. It plays a vital role in a wide range of physiological processes in the body. For instance, in cardiovascular system NO acts as a blood vessel relaxant, while in central nervous system (CNS) it acts as a neurotransmitter. In reproductive system it regulates gonadotrop...
[ 5 ] - in vitro Anti-Proliferative Effect of Adiponectin on Human Endometriotic Stromal Cells through AdipoR1 and AdipoR2 Gene Receptor Expression
Background: Endometriosis is a complex disorder in reproductive age women which consist of stromal and epithelial cells implantation outside the uterine cavity. Adiponectin is a member of cytokine family with various metabolic roles and proliferation inhibition of many cancer cells. The aim of the present research was to determine adiponectin effect on human endometriotic stromal cells (ESCs) p...
[ 6 ] - پیشرفت های اخیر در انجماد تخمک: یک مطالعه مروری
It is now more than three decades since the first live birth from oocyte cryopreservation. At present, oocyte cryopreservation has become a major component of Assisted Reproductive technologies (ART). Across the world, there is an increasing demand, especially for so-called ‘social egg freezing’ that allows women to preserve their fertility in anticipation of age-related fertility d...
[ 7 ] - مدل های تجربی ایجاد ترومبوسیتوپنی درحیوانات آزمایشگاهی و کاربرد آنها در شناسایی عوارض داروهای شیمی درمانی
سابقه و هدف: ترومبوسیتوپنی از عوارض داروهای شیمی درمانی، می باشد که می تواند باعث مرگ شود. مدل های مختلف حیوانی ترومبوسیتوپنی برای تحقیقات بالینی و شناسایی عوامل ایجاد کننده آن بکار میروند که هر یک مزایا و معایبی دارند. هدف از این مطالعه مروری، بررسی روشهای القای ترومبوسیتوپنی در حیوانات آزمایشگاهی و مزایا و معایب آنها میباشد. مواد و روش ها: این مطالعه مرور سیستماتیک با استفاده از کلید واژها...
[ 8 ] - اثر ترمیمی کهورک (Prosopis farcta) بر پارامترهای باروری و وضعیت آنتی اکسیدانی موشهای صحرایی دیابتی
سابقه و هدف: کهورک دارای خواص ضددیابتی و آنتیاکسیدانی است و ممکن است در جلوگیری از آثار مخرب دیابت بر بافت بیضه مفید باشد. مطالعه حاضر با هدف بررسی اثر میوه کهورک بر پارامترهای باروری، وضعیت آنتیاکسیدانی و ساختار بافت بیضه موشهای صحرایی دیابتی انجام گرفت. مواد و روشها: در این مطالعه تجربی، 32 سر موش صحرایی نر بالغ نژاد ویستار (220-200 گرم) به 4 گروه کنترل، کهورک، دیابتی و دیابتی+کهورک تقسیم...
[ 9 ] - Noscapine Inhibiting the Growth and Angiogenesis of Human Eutopic Endometrium of Endometriosis Patients through Expression of Apoptotic Genes and Nitric Oxide Reduction in Three-Dimensional Culture Model
Noscapine is a natural alkaloid with anti-angiogenesis activities. The aim of the present study was to examine the effect of noscapine on eutopic endometrium of endometriosis patients (EEE) and normal endometrium (NE)in a three-dimensional (3D) culture model. In this experimental in-vitro study, EEE (n = 8) and NE (n = 8) biopsies were taken from 16 reproductive aged women. The biopsie...
[ 10 ] - Noscapine Inhibiting the Growth and Angiogenesis of Human Eutopic Endometrium of Endometriosis Patients through Expression of Apoptotic Genes and Nitric Oxide Reduction in Three-Dimensional Culture Model
Noscapine is a natural alkaloid with anti-angiogenesis activities. The aim of the present study was to examine the effect of noscapine on eutopic endometrium of endometriosis patients (EEE) and normal endometrium (NE)in a three-dimensional (3D) culture model. In this experimental in-vitro study, EEE (n = 8) and NE (n = 8) biopsies were taken from 16 reproductive aged women. The biopsie...
[ 11 ] - A Review on Therapeutic Effects of Tribulus terrestris
Tribulus terrestris is a one-year-old herb dispersed in hot and humid areas in the Mediterranean and warm regions of Europe, Asia, Africa and Australia. This plant has many benefits and is used in traditional medicine for the treatment of various diseases, including kidney stones, low blood pressure, anti-diabetic properties, and treatment of cardiovascular diseases, gastrointestinal disorders,...
[ 12 ] - Natural and herbal compounds targeting breast cancer, a review based on cancer stem cells
Cancer stem cells (CSCs) are known as the major reason for therapy resistance. Recently, natural herbal compounds are suggested to have a significant role in inhibiting the breast cancer stem cells (BCSCs). The aim of this study was to explore the effective natural herbal compounds against BCSCs.This review article was designed based on the BCSCs, mechanisms of therapy resistance and natural he...
[ 13 ] - Relationship between Serum Levels of Anti-Mullerian Hormone, Adiponectin and Oxidative Stress Markers in Patients with Polycystic Ovary Syndrome
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Anti-Mullerian hormone (AMH) is a valid indicator of ovarian function and is used for PCOS diagnosis. Some studies have shown that adipokines affect the synthesis of AMH, and therefore they are somehow related in function. The aim of the present study was to determine the relationshi...
[ 14 ] - Royal Jelly Promotes Ovarian Follicles Growth and Increases Steroid Hormones in Immature Rats
Objective Royal jelly (RJ) is a complementary diet widely used by traditional healers for the treatment of infertility. The aim of present study was to evaluate the effect of RJ on some reproductive parameters in immature female rats. MaterialsAndMethods In this experimental study, thirty two immature female rats (30-35gr) were divided into four groups (n=8 /group). Control group received 0.5 m...
[ 15 ] - Reactive oxygen species generation and use of antioxidants during in vitro maturation of oocytes: a Review
In vitro maturation (IVM) is emerging as a popular technology at the forefront of fertility treatment and preservation. However, standard in vitro culture conditions usually increase reactive oxygen species (ROS), which have been implicated as one of the major causes for reduced embryonic developmental competence. It is well-known that higher than physiological levels of ROS triggers granulosa ...
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