Fatemeh Ghaffarifar
Department of Parasitology , Faculty of Medical Sciences, Tarbiat Modares University,Tehran,.Iran.
[ 1 ] - Apoptotic effect of morphine, imiquimod and nalmefene on promastigote , infected and uninfected macrophages with amastigote of Leishmania major by flow cytometry
The parasites of genus Leishmania are the causative agents of one of the most widespread and devastating diseases. According to follow-up data, these medications may provoke adverse drug reactions, drug resistance, relapse as well as financial burden. The mechanism of action of opioid drugs are primarily exerted via transmembrane G-protein coupled receptors. One of the potent synthetic immunomo...
[ 2 ] - In-vitro evaluation of antileishmanial activity and toxicity of artemether with focus on its apoptotic effect
Artemisinin and its derivatives are very important new class of antimalarial drugs. One of the most important artemisinin derivatives is artemether. The antiparasitic activity of artemether as a derivative of artemisinin is related to endoperoxide bridge in its structure. The aim of this study was the evaluation of antileishmanial effect of artemether, with more focus on its apoptotic effect. I...
[ 3 ] - Therapeutic effects of Lucilia sericata larvae on cutaneous leishmaniasis wounds caused by Leishmania major using BALB/c mice as animal model
Background: Cutaneous Leishmaniasis (CL) is an endemic disease in Iran. The pentavalent antimonials as first-line drugs are losing efficacy because of side effects, disease relapse and drug resistance. Application of Lucilia sericata larvae (maggot therapy) to diabetic and refractory wounds approved to be satisfactory for accelerating healing process. In this study, th...
[ 4 ] - Apoptotic effect of morphine, imiquimod and nalmefene on promastigote , infected and uninfected macrophages with amastigote of Leishmania major by flow cytometry
The parasites of genus Leishmania are the causative agents of one of the most widespread and devastating diseases. According to follow-up data, these medications may provoke adverse drug reactions, drug resistance, relapse as well as financial burden. The mechanism of action of opioid drugs are primarily exerted via transmembrane G-protein coupled receptors. One of the potent synthetic immunomo...
[ 5 ] - In-vitro evaluation of antileishmanial activity and toxicity of artemether with focus on its apoptotic effect
Artemisinin and its derivatives are very important new class of antimalarial drugs. One of the most important artemisinin derivatives is artemether. The antiparasitic activity of artemether as a derivative of artemisinin is related to endoperoxide bridge in its structure. The aim of this study was the evaluation of antileishmanial effect of artemether, with more focus on its apoptotic effect. I...
[ 6 ] - تعیین گونه های مولد لیشمانیوز جلدی ایزوله های مختلف جدا شده از بیماران مراجعه کننده به بیمارستان رازی، تهران، سال 1389 با استفاده از ژن ITS1 و آنزیم Apo1 با روش ملکولی PCR-RFLP
مقدمه: لیشمانیوزیس از بیمــاری های مهم بومی در ایران است و به دو نوع جلدی و احشایی دیده می شود. از آن جائی که تعیین گونه این انگل در کنترل و پیش گیری بیماری موثر است، لذا این مطالعه با هدف تعیین گونه لیشمانیوز جلدی طراحی و اجرا گردید. مواد و روش ها: در این مطالعه از 35 بیمار مبتلا به لیشمانیازیس جلد 18 مورد آلودگی از اصفهان(حاشیه اطراف اصفهان، اردستان، کاشان و سمیرم) 2 مورد از کرمان(کانون آ...
[ 7 ] - Enhancement effect of Shark Cartilage extract on treatment of Leishmania infantum with Artemisinin and Glucantime and evaluation of killing factors and apoptosis in vitro condition
In this study we examined enhancement effects of Artemisinin plus Glucantime and shark cartilage extract, on promastigotes and amastigotes of L.infantum in in vitro condition.The toxicity of artemisinin, glucantime and shark cartilage extract on the L. infantum promastigotes and amastigote-infected macrophages was evaluated using MTT assay. The role of these drugs in inducing apoptosis in proma...
[ 8 ] - Enhancement effect of Shark Cartilage extract on treatment of Leishmania infantum with Artemisinin and Glucantime and evaluation of killing factors and apoptosis in vitro condition
In this study we examined enhancement effects of Artemisinin plus Glucantime and shark cartilage extract, on promastigotes and amastigotes of L.infantum in in vitro condition.The toxicity of artemisinin, glucantime and shark cartilage extract on the L. infantum promastigotes and amastigote-infected macrophages was evaluated using MTT assay. The role of these drugs in inducing apoptosis in proma...
[ 9 ] - اتاثیرویتامینهای C و Eدربالابردن سطح نیتریک اکساید وافزایش کشتن تاکی زوئیتهای توکسوپلاسما گوندی توسط ماکروفاژها در موشهای حساس BALB/c
مقدمه: توکسوپلاسما گوندی یک انگل داخل سلولی اجباری و عامل عفونت توکسوپلاسموزیس و دارای دو فرم غیر مهاجم برادی زوئیت و مهاجم تاکی زوئیت می باشد . هدف این تحقیق برای اولین باربررسی تاثیر ویتامینهای Cو Eدربالا بردن سطح سرمی نیتریک اکساید و نقش فزاینده آن درکشتن تاکی زوئیتهای مهاجم انگل درموشهای حساسBALB/c می باشد. روش کار: چهارده 14 گروه 5 تایی (70سر) موش BALB/cبطور تصادفی به دو گروه کنترل ومورد ت...