Hamid Galehdari
Dept. of Genetic, Shahid Chamran University, Ahvaz, Iran
[ 1 ] - Lack of Mutation in the Hot Spot Region of the Human P53 Gene in a Number of Iranian Hepatocellular Carcinoma Patients
Objectives and Background: Mutation directed inactivation of the tumor suppressor gene p53 have been found incountries with high frequency for hepatocellular carcinomas (HCCs). Our goal in the present study was screening of the p53 gene in tumor tissues from HCC affected individuals in southwest Iran for putative mutations in exons 7 and 8 that are known as hot spot regions. Materials & Met...
[ 2 ] - Molecular Analysis of Microsatellite Instability in Hereditary Non Polyposis Colon Carcinoma Patients from North-East Iran
Background and Objectives: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by germ-line mutations in DNA mismatch repair genes. Tumors arising as a result of these mutations display instability in a sequence area known as microsatellites. Studies have shown that some Bethesda markers (BAT25, BAT26) are more efficient than other...
[ 3 ] - Study of β-tubulin gene polymorphisms in Haemonchus contortus isolated from sheep populations in Khouzestan, southwestern Iran
In this report, β-tubulin gene polymorphism was investigated in Haemonchus contortus populations isolated from sheep flocks in different regions of Khouzestan province, southwestern Iran. The samples were chosen on the basis of regional variation in benzimidazole treatment background of sheep flocks. Our objective was to study the relationship between treatment background andβ -tubulin gene po...
[ 4 ] - Association study between schizophrenia and the DISC1 gene polymorphism
Abstract Background: The disrupted-in-schizophrenia 1 (DISC1) gene, on the chromosome position 1q42, was initially identified at the breakpoint of a balanced translocation, t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large Scottish family. Methods: Our samples included 200 unrelated patients diagnosed with Schizophrenia on the basis of DSM-IV criteria an...
[ 5 ] - Cloning and Expression of VP2 Gene of Infectious Bursal Disease Virus in Eukaryotic Cells
Infectious bursal disease (IBD) is an economically important viral disease of chickens with worldwide distribution which suppresses the immune system of young chickens. VP2 is the major host-protective protein of infectious bursal disease virus (IBDV). The encoding region of VP2 protein was PCR amplified from a plasmid containing a cDNA fragment of large genomic segment of IBDV, strain D78. Thi...
[ 6 ] - بررسی فراوانی انواع جهش های ژن بتاگلوبین در بیماران بتا تالاسمی ماژور و اینترمدیا مراجعه کننده به بیمارستان شفای اهواز در سالهای 1390_1395
چکیده هدف: بتا تالاسمی از بیمار یها ی تک ژنی رایج در ایران محسوب می شود.با توجه به جمعیت چند قومیتی ایران، انتظار می رود طیف وسیعی از موتاسیون ها در این کشور وجود داشته باشـد. فراوانـی ژن بتا تالاسمی در ایران بالا بوده و از نظر نوع نیز تفاوت های قابل ملاحظه ا ی با مناطق مختلف وجود دارد،.به همین دلیل لازم است تا فراوانی و انتشار جهش ها در قسمت های مختلف کشور تعیین شود. روش بررسی: با ...
Co-Authors