Nafiseh Pakravan
Dept. of Microbiology & Immunology, Medical School, Alborz University of Medical Sciences, Karaj, Iran
[ 1 ] - Liver Damage and Mortality in a Male Lewis Rat of Experimental Autoimmune Encephalomyelitis
Background and Objectives: Multiple sclerosis is an inflammatory disease of the central nervous system. This is due to migration of peripherally activated lymphocytes to central nervous system leading to inflammatory lesions. However, liver has an anti-inflammatory microenvironment. Myelin expression in the liver of transgenic mice suppresses inflammatory lesions within central nervous system. ...
[ 2 ] - استفاده از روش بحث در گروه‌های کوچک به صورت دو مرحله‌ای برای افزایش یادگیری درس ایمنی‌شناسی پایه
زمینه و هدف: روش بحث در گروه‌های کوچک یکی از معتبرترین روش‌ها جهت یادگیری عمیق می‌باشد. این روش بر اساس شرکت فعال همه اعضای گروه شکل می‌گیرد. از طرف دیگر، درس ایمنی‌شناسی پایه به تفکر و برقراری ارتباط بین مطالب ارایه شده نیاز دارد. بنابراین، در مطالعه حاضر از روش بحث در گروه‌های کوچک استفاده و تأثیر این روش در افزایش درک دانشجویان از ارتباط بین اجزای سیستم ایمنی ارزیابی شد. روش کار: درس ایم...
[ 3 ] - Filtered Kombucha tea ameliorates the leaky gut syndrome in young and old mice model of colitis
Objective(s): Zonula occludens proteins (ZO-1 and ZO-2) are important intracellular tight junction (TJ)-associated proteins that link the cell cytoskeleton to the trans-membrane TJ proteins. Destruction of TJ proteins is called the “leaky gut syndrome” and has been observed in some of the gastrointestinal diseases such as the inflammatory bowel disease (IBD). So, ther...
[ 4 ] - Kinetics of T cell response in the testes and CNS during experimental autoimmune encephalomyelitis: Simultaneous blood-brain and -testis barrier permeability?
Objective(s): Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are regarded as autoimmune diseases of the central nervous system (CNS). The CNS, testes, and eyes are immune privileged sites. It was initially presumed that ocular involvement in EAE and infertility in MS are neural-mediated. However, inflammatory molecules...
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