Parviz Owlia
Molecular Microbiology Research Center, Faculty of Medicine, Shahed University, Tehran, Iran.
[ 1 ] - Conserved OprF as a Selective Immunogen Against Pseudomonas aeruginosa
Background & Objectives: Due to the importance of Pseudomonas aeruginosa in severe inpatient infections and high mortality, the need for an efficient vaccine against these bacteria is increasing. In this regard, the general outer membrane porin of the most problematic microorganism P. aeruginosa, outer membrane protein F (OprF), is a good vaccine cand...
[ 2 ] - Investigation of Efflux-Mediated Tetracycline Resistance in Shigella Isolates Using the Inhibitor and Real Time Polymerase Chain Reaction Method
Background: Shigella spp. are gram negative bacteria, which are of global public health importance. The growing of multidrug-resistant Shigella isolates are a major problemaround the world. Methods: Overall, 50 isolates of Shigella spp. from children diarrheic stools w...
[ 3 ] - Isolation of indigenous Glutathione producing Saccharomyces cerevisiae strains
Background: Glutathione (GSH) is a non-protein thiol compound, which plays an important role in the response to oxidative stress and nutritional stress. The aim of this study was to isolate indigenous S. cerevisiae strains capable of effectively produce GSH. Methods: One hundred-twenty sweet frui...
[ 4 ] - Detection of Multidrug Resistant (MDR) and Extremely Drug Resistant (XDR) P. Aeruginosa Isolated from Patients in Tehran, Iran
Background: This study was done to detect multidrug resistant (MDR) and extremely drug resistant (XDR) of Pseudomonas aeruginosa among strains isolated from patients in Tehran, Iran, due to importance of these phenotypes in treatment of human infections. Methods: Eighty eightP. aeruginosa were isolated from patients in Tehran, Iran, and identified by routine...
[ 5 ] - Cytobiochemical Potentials of Rosa damascenaMill. Extract
Background and Objectives: There is a profound inclination among people toward consumption of herbs and herbal products. Some of these products are harmful while health-promoting potentials of some others should be discovered. In the present study the antibacterial, antioxidant, acute and subchronic and cancer cell toxicity of methanolic and aqueous extracts of Rosa damascena ...
[ 6 ] - Detection of CTX-M-β Lactamases form Isolated Klebsiella pneumoniae
Background and Objective: Organisms producing CTX-M β-lactamases are emerging as a source of resistance to oxyiminocefalosporins such as ceftriaxone and ceftazidime. However, the laboratory detection of these strains is not well defined. In this study, phenotypic assay for screening of extended-spectrum β-lactamases producing strains and molecular assay for the identification of CTX-M β-lact...
[ 7 ] - In Vitro Bactericidal Activity of Encapsulated Amikacin in Liposome
Background and Objectives: The most common problems limiting the medical use of aminoglycosides have been the nephro- and oto-toxicities as well as the increasing bacterial resistance. Encapsulation of drugs into liposomes enhances their efficacy while reducing their toxicities. The aim of this study was to evaluate the antimicrobial activity of free and liposomal amikacin. Material and Metho...
[ 8 ] - Prevalence of Macrolide-Lincosamide-Streptogramin B (MLSB) Resistance in S. aureus Isolated from Patients in Tehran, Iran
Background and Objectives: Staphylococcus aureus is an important cause of nosocomial and community-acquired infections in every region of the world. Clindamycin is one of the alternative agents used to treat S. aureus infections and accurate identification of clindamycin resistance is important to prevent therapeutic failure. Unfortunately, inducible clindamycin resistance is ...
[ 9 ] - Susceptibility To Vancomycin In Staphylococcus Aureus Isolated From Patients Of Four University-Affiliated Hospitals In Tehran
Background and Objective: Vancomycin is frequently the antibiotic of choice for the treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA). For the last years, the incidence of vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA) has been increased in various parts of the world. The present study ...
[ 10 ] - Detection Of Methicillin Resistance In Staphylococcus Aureus By Disk Diffusion And PCR Methods
Background and Objective: Methicillin resistance in Staphylococcus aureus is an increasingly important clinical problem. A chromosomal gene, mecA, mediates resistance to penicillinase-resistant penicillins such as methicillin and oxacillin in Staphylococcus aureus. We evaluated the validity of disk diffusion test by using oxacillin, methicillin an...
[ 11 ] - Phenotypic Detection Of Metallo-beta-lactamase Producing Pseudomonas aeruginosa Strains Isolated From Burned Patients
Background and Objective: Metallo-beta-lactamase (MBL)-mediated resistance is an emerging threat in hospital isolates of Pseudomonas aeruginosa. There is not enough information from Iran regarding the prevalence and the screening methods for such enzymes. The present study was undertaken to detect Metallo betalactamase in strains of P. aeruginosa isolated from burned patien...
[ 12 ] - A Novel High-Performance Liquid Chromatography Method for Detection of Alginate in Pseudomonas aeruginosa
Background and Objective: The opportunistic pathogen Pseudomonas aeruginosa secrets a capsule-like polysaccharide called alginate which is important for evasion of host defenses, especially in patients with suppressed immunity. Method of alginate determination has an important role in the study of microb...
[ 13 ] - A 3-Year Study Of Demographic Characteristics Of Patients With Urinary Tract Infection, Microbial Etiology, And Susceptibility Of Isolated Bacteria To Antibiotics In Shaheed Mostafa Khomeini Hospital
Background and Objectives: This study was designed as a retrospective study on urine samples during three years in Shaheed Mostafa Khomeini Hospital to determine demographic characteristics of patients with urinary tract infection (UTI), microbial etiology, and susceptibility of isolated bacteria to anti...
[ 14 ] - Drug resistance of isolated strains of Pseudomonas Aeruginosa from burn wound infections to selected antibiotics and disinfectants
Background and Objectives: Infection is the most common problem following burn injury. Selection and dissemination of intrinsic and acquired resistance mechanisms increase the probability of burn wound colonization by resistant species including Pseudomonas aeruginosa. Multi-drug resistant Pseudomonas ae...
[ 15 ] - Effects of Sub-inhibitory Concentrations of Essential Oils of Mentha spicata and Cumminum cyminum on Virulence Factors of Pseudomonas aeruginosa
Background : Pseudomonas aeruginosa is one of important opportunistic pathogen, that cases serious infections . It produces many virulence factors, and this bacterium usually is resistance against antimicrobial agents. Objective :The aim of this study was evaluate the effects of sub-MICs of essential oils of Mentha spicata and Cumminum cyminum on alginate production, biofilm formation, swim...
[ 16 ] - بررسی اثر ضدمیکروبی ساکارومیسس سرویزیه علیه انتروتوکسیژنیک و انتروهموراژیک اشریشیاکلی
زمینه و هدف: پروبیوتیکها میکروارگانیسمهایی سودمند برای سلامتی جوامع هستند. ساکارومیسس سرویزیه یکی از گونههای استفادهشده در بهبود کارکرد و درمان بیماریهای دستگاه گوارش و مهار پاتوژنهای رودهای است. پاتوتایپهای انتروهموراژیک اشریشیاکلی (EHEC) و انتروتوکسوژنیک (ETEC) دو بیماریزای رودهای شایع در جهان هستند که سبب اسهال میشوند. هدف این مطالعه، بررسی اثر ضدمیکروبی عصاره مایع رویی کشت و لیز...
[ 17 ] - Characterization of Pseudomonas aeruginosa in Burn Patients Using PCR- Restriction Frag-ment Length Polymorphism and Random Amplified Polymorphic DNA Analysis
One of the major opportunistic pathogens in patients with burn injuries is Pseudomonas aeruginosa, which causes severe infections in burned patients. The objective of the study was to examine the molecular epidemiology of P. aeruginosa colonization in the burn unit of Shahid Motahari Hospital in Tehran, Iran. Restriction fragment length polymorphism (RFLP) and random amplified polymorphic DNA (...
[ 18 ] - The effect of subinhibitory concentrations of satureja spp. essential oils on the biofilm formation and urease activity of Klebsiella pneumoniae
Background: Klebsiella pneumoniae is one of the most important bacteria that cause nosocomial infections. This opportunistic pathogen has a high potential for antibiotic resistance and can generate a thick layer of biofilm. Nowadays, antibiotic resistant strains are emerging and widely spreading worldwide. Thus, it is necessary to combat drug-resistant strains through the use of novel drugs (su...
[ 19 ] - Inhibitory Effect of Supernatant and Lysate of Saccharomyces cerevisiae on Expression of exoA Gene of Pseudomonas aeruginosa
Background and Aim: Pseudomonas aeruginosa is an important ubiquitous and especially common pathogen in the hospital. Exotoxin A that encoded by exoA gene has a role in pathogenesis of this bacterium. Today, probiotics are widely used in the treatment and prevention of diseases. The present study aimed to study the Saccharomyces cerevisiae S3 effect on the expression of exoA gene. Materials an...
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