Mohammad Tavangar

Dept of Pathology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

[ 1 ] - A Review of Driver Genetic Alterations in Thyroid Cancers

Thyroid cancer is a frequent endocrine related malignancy with continuous increasing incidence. There has been moving development in understanding its molecular pathogenesis recently mainly through the explanation of the original role of several key signaling pathways and related molecular distributors. Central to these mechanisms are the genetic and epigenetic alterations in these pathways, su...

[ 2 ] - Expression of Prostate-Specific Membrane Antigen (PSMA) in Brain Glioma and its Correlation with Tumor Grade

Background & Objective Angiogenesis is an essential component of tumor growth. Expression of PSMA on the neo-vasculature of many solid tumors, including glioblastoma multi-form, has been determined. The pattern of expression suggests that PSMA may play a functional role in angiogenesis. Methods: expression of PSMA in dif...

[ 3 ] - Current Diagnostic Status of Pheochromocytomaand Future Perspective: A Mini Review

Pheochromocytomas (PCCs) are rare neuroendocrine tumors. The current diagnostic tools are based on biochemistry and histopathology results, but heterogeneity of diagnostic markers, signs and symptoms of PCCs bring a lot of difficulties for these two current methods. Unfortunately microscopic understanding of PCCs is not adequate for its confident prognosis and management. There are data linking...

[ 4 ] - Meningeal Hemangiopericytoma in 33-Year-Old Female; a Case Report

Intracranial hemangiopericytomas (HPC) are rare vascular tumors. They account for 0.4% of primary central nervous system tumors. HPC is more commonly located supratentorially and tends to occur in a younger age group, with average age at presentation of 38–42 years. The tumor was found throughout the entire CNS, usually superficially and closely related to the meninges. Moreover, they have a st...

[ 5 ] - Meningioangiomatosis in an otherwise healthy 13 year-old boy: A case report with emphasis on histopathological findings

Meningioangiomatosis is regarded as a rare benign hamartomatous condition mostly involving the cerebral cortex and overlying leptomeninges. A strong association of MA with neurofibromatosis type 2 has been documented in published articles. Herein we report a case of an otherwise healthy 13-year-old boy with no family history or stigmata of neurofibromatosis who presented with intractable seizur...

[ 6 ] - بررسی بروز مارکر سلولی nm23 در نئوپلاسم‌های خوش‌خیم و بدخیم تیروئید به روش ایمونوهیستوشیمی

عوامل پیش‌آگهی دهنده‌ی متعددی در سرطان‌های تیروئید نقش دارند که از جمله مهم‌ترین آن‌ها مرحله‌ی بالینی تومور و وجود یا عدم وجود متاستاز دوردست است. nm23 یک ژن سرکوبگر متاستاز است و نقش آن در بسیاری از سرطان‌ها شناخته شده است. هدف این مطالعه بررسی بروز مارکر سلولی nm23 به روش ایمونوهیستوشیمی ‌در تومورهای خوش‌خیم و بدخیم تیروئید و ارتباط آن با اندازه‌ی تومور، تهاجم عروقی و کپسولی و درگیری گره لنفا...

[ 7 ] - بررسی بروز نشانگر سلولی رتینوبلاستوم (Rb) در نئوپلاسم‌های خوش‌خیم و بدخیم تیروئید

عوامل متعددی در پاتوژنز نئوپلاسم‌های تیروئید نقش دارند. نقش موتاسیون ژن تضعیف‌کننده‌ی تومور Rb (رتینوبلاستوم) نیز در پاتوژنز بدخیمی تیروئید مطرح شده است. هدف این مطالعه بررسی میزان بروز ژن Rb در تومورهای تیروئید و ارتباط آن با سایر یافته‌های بالینی و میکروسکوپی به منظور استفاده‌ی احتمالی از آن برای افتراق نئوپلاسم‌های خوش‌خیم از بدخیم تیروئید و هم‌چنین به عنوان یک عامل پیش‌گویی‌کننده‌ی است. موا...

[ 8 ] - بررسی آنژیوژنز در نئوپلاسم‌های بدخیم تیروئید با استفاده از روش ایمونوهیستوشیمی

مقدمه: بدخیمی‌‌های تیروئید از جمله بدخیمی‌‌های شایع غدد درون‌ریز می‌باشد که نقش آنژیوژنز در آنها به خوبی مشخص نشده است و تحقیق بیشتر در این زمینه ضروری است. آنژیوژنز از عوامل لازم در رشد، بقا و گسترش بسیاری از سرطان‌هاست. هدف این مطالعه بررسی وجود یا عدم وجود آنژیوژنز در تومورهای بدخیم تیروئید و ارتباط آن با یافته‌های بالینی و میکروسکوپی است. مواد و روش‌ها: در یک مطالعه توصیفی، دویست و پنج نمون...

[ 9 ] - Dyspnea as the First Manifestation of Silent Renal Cell Carcinoma

Renal cell carcinoma (RCC) accounts for only 3% of adult malignancies, and the lung is the most common site of metastasis of this tumor, which may be accompanied by pleural metastasis. However, solitary pleural involvement is very rare and its presentation with dyspnea as the first manifestation of RCC is extremely rare.We describe a 39-year-old male with episodes of dyspnea dating back 6...

[ 10 ] - Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma

Background & Objective: Papillary thyroid cancer (PTC) is considered to be the most common type of thyroid malignancies. Epigenetic alteration, in which the chromatin conformation and gene expression change without changing the sequence of DNA, can occur in some tumor suppressor genes and oncogenes. Methylation is the most common type of epigenetic alterations that can be an ex...

[ 11 ] - Biphasic Epithelial Predominant Synovial Sarcoma Presenting as Painful Thigh Mass

Synovial sarcomas are soft tissue neoplasms mostly located in the lower extremities of young adults. A case of synovial sarcoma of the thigh in a 35-year-old male with the predominant epithelial component is reported. Microscopically the tumor showed variable-sized well-differentiated glands lined by the cuboidal cells with small foci of spindle cell component between glandular structures...

[ 12 ] - Heterotopic Pancreas as a Leading Point of Intussusception: A Case Report

Heterotopic pancreas (HP) is generally asymptomatic and found incidentally. It can act very rarely as a leading point for intussusception. Thus, it should be considered as a differential diagnosis of the mass lesions leading to the intestinal intussusception. Herein, we report an unusual case of HP as a cause of ileocolic intussusception.

[ 13 ] - Liquid Biopsy as a Minimally Invasive Source of Thyroid Cancer Genetic and Epigenetic Alterations

In the blood of cancer patients, some nucleic acid fragments and tumor cells can be found that make it possible to trace tumor changes through a simple blood test called “liquid biopsy”. The main components of liquid biopsy are fragments of DNA and RNA shed by tumors into the bloodstream and circulate freely( ctDNAs and ctRNAs). tumor cells which are shed into the blood (circulating tumor cells...

[ 14 ] - Mature Cystic Teratoma of Spinal Cord in A 16-Year-Old Male: A Case Report

Teratoma is a type of multipotential cell tumor, which includes a mixture of two or three germinal layers of ectodermis, endodermis, and mesodermis. Although neonatal sacrococcygeal teratoma has been frequently reported, its occurrence in older age is not common. In this study, we report a rare case of spinal intradural mature cystic teratoma in a 16-year-old male, emphasizing on considering th...