Amir Hakimi
Health Physics and Dosimetry Laboratory, Department of Energy Engineering and Physics, Amir Kabir University of Technology, Tehran, Iran
[ 1 ] - A Model of Time-dependent Biodistribution of 153Sm-Maltolate Complex and Free 153Sm Cation Using Compartmental Analysis
Introduction Compartmental analysis allows the mathematical separation of tissues and organs to determine activity concentration in each point of interest. Biodistribution studies on humans are costly and complicated, whereas such assessments can be easily performed on rodents. In this study, we aimed to develop a pharmacokinetic model of 153Sm-maltolate complex as a novel therapeutic agent and...
[ 2 ] - Determination of human absorbed dose from [153Sm]-Samarium maltolate based on distribution data in rats
Background: Therapeutic radiopharmaceuticals are designed to deliver high doses of radiation to selected target organs with an aim of minimizing unwanted radiation to surrounding healthy tissue. Due to the potential of targeted radiotherapy to treat a wide range of malignant conditions, [153Sm]-samarium maltolate was developed for possible therapeutic applications. Materials and Methods: The or...
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