Abdolamir Allameh
Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University
[ 1 ] - Immunoregulatory Effects of Glutathione During Mesenchymal Stem Cell Differentiation to Hepatocyte-Like Cells
Background: The role of mesenchymal stem cell in cellular therapy is the subject of interest for many researchers. The differentiation potential of MSCs and abilities in modulations of the recipient’s immune system makes them important cells in tissue regenerative studies. MSCs by releasing the proinflammatory cytokines play important role in immunomodulatory systems; however the signaling path...
[ 2 ] - Heterologous Immunization, a Way out of the Problem of Monoclonal Antibody Production against Carcinoma Antigen 125
Background: Monoclonal antibodies (mAbs) are essential tools for many molecular im-munology investigations, epitope mapping and molecular modelling, clinical laboratory di-agnostic tests and immunotherapy. Humoral immune response of immunized animals largely depends on the nature of antigen and the immunization technique. Polysaccharides and heavily-glycosylated proteins are very elusive target...
[ 3 ] - Tehranolide Could Shift the Immune Response towards Th1 and Modulate the Intra-Tumor Infiltrated T Regulatory Cells
Background: Artemisia diffusa contains a new type of sesquiterpene lactone with an endoperoxide group (Tehranolide). Objective: Due to the existing similarity between the structures of Tehranolide and Artemisinin, it was hypothesized that Tehranolide would have similar effects as Artemisinin. In this study, the immunotherapeutic effec-tiveness of Tehranolide was investigated by direct intra-tum...
[ 4 ] - Protective Effects of α-Tocopherol on ABR Threshold Shift in Rabbits Exposed to Noise and Carbon Monoxide
Noise induced hearing loss (NIHL) is one of the most important occupational disease worldwide. NIHL has been found potentiate by simultaneous carbon monoxide (CO) exposure. Free radicals have been implicated in cochlear damage resulted from the exposure to noise and due to the CO hypoxia. This study examined whether α-tocopherol administration, as a free radical scavenger, causes the attenuatio...
[ 5 ] - Protective Effects of α-Tocopherol on ABR Threshold Shift in Rabbits Exposed to Noise and Carbon Monoxide
Noise induced hearing loss (NIHL) is one of the most important occupational disease worldwide. NIHL has been found potentiate by simultaneous carbon monoxide (CO) exposure. Free radicals have been implicated in cochlear damage resulted from the exposure to noise and due to the CO hypoxia. This study examined whether α-tocopherol administration, as a free radical scavenger, causes the attenuatio...
[ 6 ] - افزایش شیب سرعت رشد و تکثیر سلول‌های بنیادی مزانشیمی مشتق از نمونه مغز استخوان انسان در حضور سیلیمارین
مقدمه: سلول‌های بنیادی مزانشیمی، از دسته سلول‌های بنیادی غیرخونساز در مغز استخوان می‌باشند. جداسازی راحت و توان تکثیری بالای این سلول‌ها در کنار حفظ توانایی تمایزی آنها به بافت‌های مختلف، این سلول‌ها را به ابزار مناسبی جهت استفاده‌های درمانی تبدیل کرده است. در سال‌های اخیر تلاش‌های زیادی در زمینه شناسایی ترکیبات مؤثر بر افزایش رشد این سلول‌ها و نگهداری آنها در حالت تمایز نیافته صورت گرفته است. ...
[ 7 ] - Diagnostic value of a combined C-reactive protein and haptoglobin tests in new cases of upper tract urothelial carcinoma
Introduction: Serum C-reactive protein (CRP) is believed to be increased in metastatic urothelial cancer of the bladder. However, the changes depend on the stage and grade of the upper tract urothelial carcinoma (UTUC). This study aimed to compare low-range and high-range serum CRP and haptoglobin in new cases of UTUC. Materials and methods: Blood was collected from newly diagnosed patient...
[ 8 ] - تأثیر اسانس و عصاره هیدروالکلی زیره سیاه (Carum carvi L.) روی پارامترهای استرس اکسیداتیو در رت‌های مبتلا به التهاب حاد ریوی قبل و بعد از پرتودهی گاما
التهاب حاد ریوی یکی از عوارض مزمن سپسیس است که در نهایت منجر به مرگ بیماران مبتلا به سپسیس می‌شود. با توجه به عوارض مصرف داروهای ضد التهابی، استفاده از گیاهان دارویی نظیر زیره سیاه (Carum carvi L.) به منظور کاهش آسیبهای ناشی از سپسیس، مورد توجه می‌باشد. در این تحقیق اثر حفاظتی اسانس و عصاره هیدروالکلی زیره سیاه در جلوگیری از آسیب ریوی در مدل تجربی التهاب حاد (CLP= Cecal Ligation and Puncture) د...
[ 9 ] - رابطه فعالیتهای ضد میکروبی روغنهای اسانسی Mentha spicata L. و Chenopodium ambrosioides L. با خواص آنتی‌اکسیدانی و رادیکال‌زدایی آنها
اسانس گیاهان پونه (Mentha spicata L.) و سلمک معطر (Chenopodium ambrosioides L.)، با روش تقطیر با بخار آب استخراج و ترکیبهای آنها با دستگاههای گاز کروماتوگرافی (GC) و گاز کروماتوگرافی متصل به طیف‌سنج جرمی (GC/MS) شناسایی شد. سپس فعالیتهای آنتی‌اکسیدانی و رادیکال‌زدایی اسانسها مورد سنجش قرار گرفته و تأثیر ضد میکروبی آنها ارزیابی شد. میکروارگانیسمهای مورد پژوهش، E. coli، S. aureus، S. enteritidis ...
[ 10 ] - اثر ضد قارچی اسانسهای .Zataria multiflora Boiss و Thymus eriocalyx (Ronniger) Jalas بر قارچ مولد آفلاتوکسین آسپرژیلوس پارازیتیکوس
اثر ضد قارچی اسانسهای آویشن شیرازی (.Zataria multiflora Boiss) و آویشن کرکی (Thymus eriocalyx (Ronniger) Jalas) از طریق مهار رشد قارچ آسپرژیلوس پارازیتیکوس NRRL 2999 مولد آفلاتوکسین بررسی شد. کمترین غلظت مهاری (MIC) و کمترین غلظت قارچ‌کشی (MFC) و سنیتیک مرگ میکروارگانیسم نسبت به اسانسهای فوق اندازه‌گیری شد. اسانسهای فوق توسط گاز کروماتوگرافی (GC) و گاز کروماتوگرافی متصل به طیف سنج جرمی (GC/MS) ...
[ 11 ] - Cross-talks between the kidneys and the central nervous system in multiple sclerosis
Multiple sclerosis (MS) is an inflammatory demyelinating disease, which is considered as a common autoimmune disorder in young adults. A growing number of evidences indicated that the impairment in non-neural tissues plays a significant role in pathology of MS disease. There are bidirectional relationship, metabolic activities and functional similarity between central nervous system (CNS) and k...
[ 12 ] - The Effect of Rebadioside A on Attenuation of Oxidative Stress in Kidney of Mice under Acetaminophen Toxicity
Background: Acetaminophen (APAP) overdose causes renal and hepatic injury. It is also believed that oxidative stress has a pivotal role in APAP-induced renal injury. Therefore, protective effects of different antioxidants have been examined in APAP-induced renal and hepatic toxicity models. Stevia rebadiana is a plant with a high degree of natural antioxidant activity in its leaf extract. T...
[ 13 ] - Oxidative stress indices in rats’ lung tissues following simultaneous exposure to noise and styrene
Background: Simultaneous exposure to noise and organic solvents such as styrene is an indispensable part of today’s industries. Numerous studies were done related to ototoxic effects of co-exposure to noise and styrene while some evidences showed the adverse effects of such exposure on other organs. In this study, we aimed to assess the subacute effects of combined exposure to noise and s...
[ 14 ] - Single administrations of high and low doses of acetaminophen causes different effects on COX-2 gene expression and on tissue damage in liver and kidneys
Introduction: High dose of acetaminophen (APAP) is known to have hepatotoxic and nephrotoxic effects and studies show that this toxicities are dependent on the function of phase I bioactivation enzymes- Cyp450- and phase II biotransformation enzymes especially glucuronosylation and sulfonation pathways. However, the role of cyclooxygenase (COX) as an inflammatory mediator in toxic effects of AP...
[ 15 ] - Development of a Novel Three-Dimensional Biocompatible Nanofibrous Scaffold for the Expansion and Hepatogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells
In this present study, we examined the differentiation potential of human bone marrow derived mesenchymal stem cells (hBMSCs) into hepatocytes on a three-dimentional (3D) nanofibrous scaffold formed by Poly (ε-caprolactone) (PCL), collagen and polyethersulfone (PES). The nanofiber was prepared by the electrospining technique. HBMSCs were isolated using combining gradient density centrifugation ...
[ 16 ] - سیکلواکسیژنازها، پیشگیری و درمان سرطان
Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two cycloxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Both enzymes are blocked by nonselective anti-inflammatory drugs (NSAID), such as indomethacin and ibuprofen. COX-1 is an enzyme normally found in tissues and is involved in physiological functions, whil...
[ 17 ] - In Vitro Anti-Mycotoxigenic and Anti-Aflatoxigenic Properties of Probiotic Bacteria; Lactobacillus plantarum and L. paracasei
The present study was designed to examine the effects of Lactobacillus plantaraum and L. paracasei on the growth and aflatoxin-producing ability of Aspergillus parasiticus. In these experiments, direct and indirect interactions of two different probiotic lactobacilli with A. parasiticus was examined.A co-culture system which supported both fungal growth and probiotic bacteria showed the inhibit...
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