Mehrnoosh Doroudchi
Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran
[ 1 ] - Resting and Activated Natural Tregs Decrease in the Peripheral Blood of Patients with Atherosclerosis
Background: Atherosclerosis is a chronic inflammatory disease affecting large and medium arteries. CD4+ T cells are known to play a role in the progression of the disease. CD4+CD25+Foxp3+ natural Treg (nTreg) cells seem to have a protective role in the disease and their reduction in acute coronary syndrome is recently shown. Objective: To investigate the frequency of nTreg subsets in the pe...
[ 2 ] - Correlation of Early and Late Ejection Fractions with CCL5 and CCL18 Levels in Acute Anterior Myocardial Infarction
Background: Acute Myocardial Infarction (AMI) is the leading cause of disability and death in Iran and many other countries. Objective: To investigate the prognostic value of CCL5 and CCL18 in patients with acute myocardial ischemia. Methods: In this cohort study we recruited and followed 50 patients with acute anterior myocardial infarction (AAMI) for developing cardiovascular accidents in a ...
[ 3 ] - Increased IL-17A in Atrial Fibrillation Correlates with Neutrophil to Lymphocyte Ratio
Background: Atrial Fibrillation (AF) is the most common cardiac arrhythmia and an independent risk factor for stroke among the elderly. A role for inflammation in the atrial remodeling as well as development and recurrence of AF is known. Objective: To compare IL-17A between patients with different types of AF and healthy individuals. Methods: IL-17A was measured in sera of 112 patients and 107...
[ 4 ] - Serum Level of HER-2 Extracellular Domain in Iranian Patients with Breast Cancer: A Follow-up Study
Background: A soluble form of HER-2/neu extracellular domain (sHER-2) is reported to be released in the sera of metastatic breast cancer patients. Objective: To measure the level of sHER-2 in sera of 115 breast cancer patients. Methods: Serial samples of 27 patients with metastasis, 18 non-metastatic patients, 15 patients in stage 0/I and 14 patients with accompanying benign breast disease were...
[ 5 ] - Lack of Association between ctla-4 A49G Polymorphism and Vitiligo
Background: Vitiligo is an acquired skin disorder that selectively destroys melanocytes in epidermis with an unknown etiology. Objective: To investigate the exon 1 A49G polymorphism of cytotoxic T lymphocyte antigen-4 (ctla-4) gene in vitiligo patients. Methods: The A49G polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method in 101...
[ 6 ] - Placental Transfer of Respiratory Syncytial Virus-Specific IgG in Iranian Mothers
Background: Respiratory Syncytical virus infection is the most common cause of bronchiolitis and viral pneumonia in infancy. Objective: To investigate the placental transfer of RSV-specific IgG in Iranian mothers. Methods: The antibodies were measured in sera of 146 mother/newborn pairs using a commercially available indirect Enzyme Linked Immunosorbent Assay (ELISA). The studied subjects were ...
[ 7 ] - Production and Characterization of Murine Monoclonal Antibodies to Leishmania Gp63 Antigen
Background : Production of monoclonal antibodies to Leishmania antigens assists the identification and characterization of these organisms. Objective: Production of monoclonal antibodies against epitopes on the gp63. Methods: Two murine monoclonal antibodies to gp63 were produced and characterized. The reactions of both antibodies with soluble leishmanial antigens, purified gp63 and truncated r...
[ 8 ] - Detection of Rheumatoid Factors in Sera and Biopsy Lesions of Vitiligo Patients
Background: Vitiligo is a dermatological disorder of unknown etiology with a common incidence in southern Iran. Presence of autoantibodies to melanocyte antigens suggested an autoimmune basis of the disease. Objective: In this study, the presence of rheumatoid factor (RF) in sera and skin biopsies of vitiligo patients was investigated. Methods: The presence of RF in sera of 35 vitiligo and 32 n...
[ 9 ] - Evaluation of pre-treatment serum levels of IL-7 and GM-CSF in colorectal cancer patients
Background: Survival of Colorectal cancer (CRC) patients is considerably stage-dependent therefore, early diagnosis is a pivotal factor in decreasing mortality and morbidity associated with this cancer. GM-CSF and IL-7 are reported to increase in different cancers and we aim to investigate the pre-treatment serum levels of GM-CSF and IL-7 in Iranian patients with colorectal cancer. Methods: ...
[ 10 ] - Correlation of CCL18 with Levels of Adi-pokines in the Sera of Patients with Myocardial Infarction in a 6-Month Period: Case Series
Background: Myocardial Infarction (MI) is accompanied by inflammation and production of soluble inflammatory factors. The aim of this study was to investigate the correlation of CCL18 and CCL5 levels with those of resistin, adipsin, adiponectin and leptin adipokines in the sera of patients after MI. Materials and Methods: The correlations between levels of chemokines and adipokines were investi...
[ 11 ] - Frequency of Efficient Circulating Follicular Helper T Cells Correlates with Dyslipidemia and WBC Count in Atherosclerosis
Background: The significance of cTfh cells and their subsets in atherosclerosis is not well understood. We measured the frequency of cTfh subsets in patients with different degrees of stenosis using flow-cytometry. Methods: Participants included high (≥50%; n = 12) and low (<50%; n = 12) stenosis groups, as well as healthy controls (n = 6). Results: The frequency of CCR7loPD-1hiefficient-cTfh w...