Jahanbakhsh Ghasemi
Department of Chemistry, Faculty of Sciences, Razi University, Kermanshah, I. R. IRAN
[ 1 ] - Potentiometric Study of Binary and Mixed Complexes of Imidazole, Histamine, Histidine and Diacetyl Monooxime with Some Transition Metal Ions in Aqueous Solution
The complexation reactions between diacetyl monooxime (Damo), imidazole (Him), histamine (Hist) and histidine (His) with Co2+, Ni2+ and Cu2+ were studied potentiometrically in aqueous solution at 25 °C and m= 0.5 M KNO3. The overall stability constants log b's of species were obtained by computer refinement of p...
[ 2 ] - Simultaneous spectrophotometric determination of lead, copper and nickel using xylenol orange by partial least squares
A partial least squares (PLS) calibration model was developed for the simultaneous spectrophotometricdetermination of Pb (ΙΙ), Cu (ΙΙ) and Ni (ΙΙ) using xylenol orange as a chromogenic reagent. The parameterscontrolling behavior of the system were investigated and optimum conditions were selected. The calibrationgraphs were linear in the ranges of 0.0–9.091, 0.0–2.719 and 0.0–2.381 ppm for lead...
[ 3 ] - Use of Volsurf approach for pharmacokinetic optimization of β-carboline derivatives as antitumor agents
The β-carboline derivatives are a large group of naturally-occurring and synthetic alkaloids which have awide spectrum of biological and pharmaceutical properties. The newly developed procedure called VolSurfhas been used to explore a significant correlation between the 3D molecular interaction fields (MIF) andphysicochemical and pharmacokinetic properties of a set of 30 β-carboline compounds a...
[ 4 ] - 3D-QSAR and docking analysis on a series of multi-cyclin-dependent kinase inhibitors using CoMFA, and CoMSIA
A series of 42 Pyrazolo[4,3-h]quinazoline-3-carboxamides as multi-cyclin-dependent kinaseinhibitors regarded as promising antitumor agents to complement the existing therapies, wassubjected to a three-dimensional quantitative activity relationship (3D QSAR). Different QSARmethods, comparative molecular field analysis (CoMFA), CoMFA region focusing, andcomparative molecular similarity indices an...
[ 5 ] - Conductometric study of the complex formation of Rb+, Cs+, NH4 +, K+, Tl+ and Ag+ ions with several crown ethers in acetonitrile-dimethylsulfoxide and acetonitrile-dimethylformamide binary mixtures
A conductance study of the interaction between Cs+, Rb+, NH4+, K+, T1+ and Ag+ ions and18-crown-6 (18C6), benzo-18-crown-6 (B18C6), dicyclohexyl-18-crown-6 (DC18C6),dicyclohexyl-24-crown-8 (DC24C8), dibenzo-24-crown-8 (DB24C8) in different binarymixtures of acetonitrile (AN) with dimethylsulfoxide (DMSO) and dimethylformamide (DMF)at 25 °C has been carried out. Formation constants of the result...
[ 6 ] - Review High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on chiral stationary phases
In recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. High-performance liquid Chromatography is a very useful method for the direct separation of enantiomers. However, about 30−40 years ago, commercially available chiral stationary phases wer...
[ 7 ] - Simultaneous Spectrophotometric Determination of Heavy Metal Ions Using Several Chemometrics Methods: Effect of Different Parameters of Savitzky-Golay and Direct Orthogonal Signal Correction Filters
Direct orthogonal signal correction(DOSC) and Savitzky-Golay filters (SGF) were applied as preprocessing methods on the original and first derivative absorbance data. Principle component regression (PCR), partial least squares (PLS) and iterative target transformation factor analysis (ITTFA), were used in spectrophotometric simultaneous determination of heavy divalent metal ions, l...
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