Enayatollah Sheikhhosseini
Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.
[ 1 ] - Synthesis of arylidinebarbituric acid derivatives catalyzed by dodecylbenzenesulfonic acid (DBSA) in aqueous media
A series of arylidine barbituric acid derivatives was synthesized by Knoevenagel condensation reaction of aromatic aldehydes with barbituric acid or thiobarbituric acid using dodecylbenzenesulfonic acid as a Brønsted acid-surfactant catalyst in aqueous media. Regardless of the nature of the substitution (electron-donating and -withdrawing), all the reactions were completed within 15-65 min in w...
[ 2 ] - A new method for synthesis of tetrahydrobenzo[b]pyrans and dihydropyrano[c]chromenes using p-dodecylbenzenesulfonic acid as catalyst in water
p-Dodecylbenzenesulfonic acid (DBSA) was used as a catalyst for a simple and efficient one-pot synthesis of aryl substititued tetrahydrobenzo[b]pyrans and dihydropyrano[c]chromens via initial Knoevenagel, subsequent Micheal and final heterocyclization reactions of aryl aldehyde, malononitrile and 4-hydroxycoumarin/dimedone in moderate to excellent yields. The present method was operationally si...
[ 3 ] - Iron Ore Pellet, A Natural and Reusable Catalyst for Synthesis of Pyrano[2,3-d]pyrimidine and Dihydropyrano[c]chromene Derivatives in Aqueous Media
We wish to report a mild and efficient one-pot three-component reaction of an aryl aldehyde, malononitrile and barbituric acid or 4-hydroxycoumarinfor the synthesis ofpyrano[2,3-d]pyrimidine and dihydropyrano[c]chromene derivatives in the presence o...
[ 4 ] - Synthesis of nocistatin C-terminal and it’s amide derivatives as an opioid peptide
A new biological active hexapeptide of C-terminal of nocistatin, contains Glu-Gln-Lys-Gln-Leu-Gln sequence was synthesized according to solid phase peptide synthesis on the surface of 2-chloro tritylchloride resin and using fmoc-protected amino acids in the presence of TBTU (O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyl uranium tetrafluoroborate) as a coupling reagent. Then, amidation of the C-te...
[ 5 ] - Uncatalyzed Synthesis of Arylmethylene[bis(5,5-dimethyl-3-hydroxy-2-cyclohexene-1-ones)] in Hot Water by Domino Knoevenagel/Michael Reactions
A simple and ecofriendly method was developed for the synthesis of arylmethylene[bis(5,5- dimethyl-3-hydroxy-2-cyclohexene-1-ones)] from the reaction of 5,5-dimethylcyclohexane- 1,3-dione and aromatic aldehydes in an aqueous media without any catalyst via Knoevenagel condensation followed by rapid Michael addition. No cyclization product was down to convert these enolic forms to xanthene deriva...
[ 6 ] - P-Dodecylbenzenesulfonic acid (DBSA), a Brønsted acidSurfactant Catalyst for Synthesis of α, ά-bis(substituted benzylidene)cycloalkanones with Electron-Withdrawing Substituent in Aqueous Media
An array of aromatic aldehydes with electron withdrawing groupunderwent crossed-Aldol condensation with cycloalkanone in the presence of catalytic amounts of DBSA under aqueous media to afford the corresponding α, ά-bis(substituted-benzylidene) cycloalkanones in good yields. The electronic effects on aromatic aldehydes could be observed. The present method is operationally simple and use of wat...
[ 7 ] - Synthesis of nocistatin C-terminal and it’s amide derivatives as an opioid peptide
A new biological active hexapeptide of C-terminal of nocistatin, contains Glu-Gln-Lys-Gln-Leu-Gln sequence was synthesized according to solid phase peptide synthesis on the surface of 2-chloro tritylchloride resin and using fmoc-protected amino acids in the presence of TBTU (O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyl uranium tetrafluoroborate) as a coupling reagent. Then, amidation of the C-te...
[ 8 ] - Synthesis of arylidinebarbituric acid derivatives catalyzed by dodecylbenzenesulfonic acid (DBSA) in aqueous media
A series of arylidine barbituric acid derivatives was synthesized by Knoevenagel condensation reaction of aromatic aldehydes with barbituric acid or thiobarbituric acid using dodecylbenzenesulfonic acid as a Brønsted acid-surfactant catalyst in aqueous media. Regardless of the nature of the substitution (electron-donating and -withdrawing), all the reactions were completed within 15-65 min in w...
[ 9 ] - A new method for synthesis of tetrahydrobenzo[b]pyrans and dihydropyrano[c]chromenes using p-dodecylbenzenesulfonic acid as catalyst in water
p-Dodecylbenzenesulfonic acid (DBSA) was used as a catalyst for a simple and efficient one-pot synthesis of aryl substititued tetrahydrobenzo[b]pyrans and dihydropyrano[c]chromens via initial Knoevenagel, subsequent Micheal and final heterocyclization reactions of aryl aldehyde, malononitrile and 4-hydroxycoumarin/dimedone in moderate to excellent yields. The present method was operationally si...
[ 10 ] - Mefenamic acid as Environmentally Catalyst for Threecomponent Synthesis of Dihydropyrano [2,3-c]Chromene and Pyrano[2,3-d]Pyrimidine Derivatives
Pills of Mefenamic acid were employed as effective catalysts in the three component reaction of aromatic aldehydes, malononitrile, as well as 4-hydroxycoumarin or barbituric acid in aqueous solution, using reflux conditions in order to synthesize derivatives of dihydropyrano[2,3-c]chromene and pyrano[2,3-d]pyrimidine, correspondingly. Among the benefits of this technique, ...
[ 11 ] - Synthesis of Arylidene (thio)barbituric Acid Derivatives using Bentonite as a Natural and Reusable Catalyst in Green Media
Known as a Lewis acid which acts as a natural catalyst, bentonite can be used to produce several arylidene (thio) barbituric acid derivatives through conducting a Knoevenagel reaction between aromatic aldehydes and (thio) barbituric acid. Water is considered as the medium for this reaction and the results are at arange of good to excellent over a reasonable reaction time. This method i...
[ 12 ] - تهیه یک سری جدید از مشتقهای کومارین در حضور نانوچندسازه Ti–Al/Al2O3 و بررسی ویژگی ضدباکتری آنها
با توجه به اهمیت مشتقهای کومارین و بهویژه پیرانوکرومنها به دلیل داشتن ویژگی متفاوت شیمیایی و زیستی در این پژوهش، مشتقهای پیرانو(h-3،2) کومارین از واکنش بنزالدهید و مشتقهای کرومن در حضور نانوچندسازه Ti–Al/Al2O3 بهعنوان کاتالیست و در حلال متانول تهیه شد. فراوردههای بهدستآمده با طیفسنجیهای FTIR، 1H NMR و 13C NMR شناسایی شدند. پس از شناسایی، ...
[ 13 ] - سنتز مشتقات 1و3 دیتین با استفاده از حلال اتکتیک سبز گلیسرول:پتاسیمکربنات و بررسی فعالیت ضد باکتریایی علیه سویههای باکتریایی مشترک بین آبزیان و انسان
ارائه روشهای نوین و سبز و پیدا کردن حلالهای دوستدار محیط زیست در سنتز ترکیبات آلی بسیار حائز اهمیت است. در این تحقیق سنتز مشتقات 1و3دی تین با استفاده از حلال اتکتیک گلیسرول:پتاسیم کربنات مورد بررسی قرار گرفت و علاوه بر این اثرات ضدباکتریایی ترکیبات سنتز شده برعلیه سویه های باکتریایی آبزیان بر مبنای قطرهاله عدم رشد (IZD)، حداقل غلظت مهارکنندگی (MIC) و حداقل غلظت کشندگی (MBC) مورد آزمون قرار گر...