Nepton Soltani
Department of Physiology, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
[ 1 ] - Relaxatory Effect of Gamma-Aminobutyric Acid (GABA) is Mediated by Same Pathway in Diabetic and Normal Rat Mesenteric Bed vessel
Objective(s) Diabetes related dysfunction of resistance vessels is associated with vascular occlusive diseases. Vasorelaxant agents may have a role in control of diabetic cardiovascular complications. Gamma aminobutyric acid (GABA) has demonstrated to cause vasorelaxation. The present study was designed to determine i) the vasorelaxatory effect of GABA on diabetic vessels and ii) the role of e...
[ 2 ] - بررسی نقش کانالهای کلسیمی و رسپتورهای آدنوزینی بر پاسخدهی عروق مقاوتی به سولفات منیزیم در رتهای دیابتی
Background: Some studies showed that magnesium can prevent diabetes complications. The present study was designed to determine the role of calcium channels and adenosine receptors in Mg2+-induced relaxation in streptozotocin (STZ) induced diabetic rats' vessels. Methods: Diabetes was induced by ip injection of 60 mg/kg STZ. Eight weeks after diabetes induction, superior mesenteric arteries w...
[ 3 ] - Renoprotective effects of GABA on ischemia/reperfusion- induced renal injury in hyperglycemic male and female rats
Introduction: Acute kidney injury (AKI) has been known as a complex clinical complication in diabetic patients. The main cause of AKI is ischemia/reperfusion injury (IRI). This study was designed to investigate the protective effects of GABA on renal IRI in hyperglycemic female and male rats. Methods: Sixty STZ induced diabetic male and female Wistar rats were categorized in 10 groups (5 fem...
[ 4 ] - Effect of magnesium on prevention of diabetic vessel complication (review article)
Introduction: Magnesium is the second intracellular and fourth common action in the body. Magnesium deficit has been described in patients with type I diabetes. Hypomagnesemia can also be the cause for some clinical diseases such as diabetes. Some researches showed that plasma magnesium level decreases after diabetes induction. Some research believed that magnesium deficiency is a risk factor f...
[ 5 ] - Effect of administration of Teucrium polium on blood glucose and lipid levels in
Introduction: Recently, the search for appropriate hypoglycemic agents has been focused on plants. Teucrium polium is traditionally used in Iran to manage, control and treat diabetes. We designed this study to elucidate the effect of the administration of oral doses of aqueous and ethanol extract from Teucrium polium on plasma glucose, lipid profiles and liver enzymes in diabetic and non dia...
[ 6 ] - Treatment effect of GABA on improve type one diabetes in NOD mice
Introduction: Gama amino butyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian nervous system. The concentration of GABA and the number of GABA cell secretion decrease in diabetic patient and experimental diabetes model. The reported effects of GABA activation on insulin secretion from beta cells have been controversial. In this study we investigated if GABA administr...
[ 7 ] - Oral herbal supplement containing magnesium sulfate improve metabolic control and insulin resistance in non-diabetic overweight patients: A randomized double blind clinical trial
Background: Magnesium deficiency plays a key role in obesity and decreases insulin sensitivity. In our previous study, significant evidence was provided for the contribution of oral Mg supplement that could improve insulin sensitivity and body weight in animal trials. The purpose of the present study was to investigate the effects of an herbal supplement containing 300 mg magnesium sulfate on l...