Aliasghar Pourshanazari

[ 1 ] - Effects of Low-dose Morphine on Nitric Oxide Concentration and Angiogenesis in Two-kidney One Clip Hypertensive Rats

Objective(s) We investigated the effects of low-dose morphine on nitric oxide (NO) and angiogenesis in two-kidney one clip hypertensive (2K1C) rats. Materials and Methods Male rats were divided into two groups: sham-clip operated and 2K1C. Each group subdivided into saline and morphine (3 mg/kg i.p. 8 weeks) groups. Blood pressure, heart rate, plasma renin activity (PRA), NO concentration an...

[ 2 ] - Vitamin E Derivative Alpha-Tocotrienol Failed to Show Neuroprotective Effects after Embolic Stroke in Rats

Objective(s) Previous studies have demonstrated that pretreatment with alpha-tocotrienol (a-TCT) can reduce ischemic damage in mice following middle cerebral artery (MCA) occlusion. It is also reported to decrease stroke- dependent brain tissue damage in 12-Lox-deficient mice and spontaneously hypertensive rats. In the present study, the neuroprotective effects of a-TCT and rosiglitazone (RGZ)...

[ 3 ] - اثر استروژن و پروژسترون بر حساسیت بارورفلکس‌ها در شرایط حاد فشار خون در موش‌های صحرایی

Background: Epidemiological studies suggested that incidence of cardiovascular diseases in menopause women is more than their nonmenopausal period. The cardioprotective role of estrogen may be responsible for some of these effects. In the present study we evaluated the role of female sex hormones on baroreflex sensitivity in acute hypertension state of rat. Materials and Methods: This was an...

[ 4 ] - نقش استروژن بر روی حساسیت بارورفلکس از طریق سیستم اتونومیک در موش های صحرایی نر

Introduction & Objective :Studies have shown that estrogen has important cardiovascular protective role. Nucleus tractus solitarii (NTS) is the termination point for all afferent of baroreceptor fibers that is important in regulation of heart function and circulation. For recognizing the estrogen mechanisms the role of estrogen through autonomic system in NTS have been evaluated. Hypertension...

[ 5 ] - مقایسه نقش ضایعه و تحریک الکتریکی هسته دسته منزوی بر حساسیت بارورفلکسها در سیستم عصبی – قلبی – عروقی رتهای معتاد به مورفین

[ 6 ] - Cardiovascular baroreflex sensitivity attenuates by cisplatin-induced toxicity in rats

Introduction: Cisplatin (CP) therapy may disturb cardiovascular system control. The objective of this study was to find baroreflex sensitivity (BRS) in CP-induced nephrotoxicity in rats. Materials and Methods: Eighteen male and female Wistar rats were randomly assigned to two groups treated with CP (2.5 mg/kg/day) and the vehicle, for five consecutive days, and then were subjected to surgical ...