Mahnaz Taherianfard
Division of Physiology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
[ 1 ] - Niacin Ameliorates Lipid Disturbances due to Glucocorticoid Administration in Rats
Objective(s) This study was conducted to evaluate the effects of niacin on glucocorticoid-induced dyslipidemia and fatty liver in rats. Materials and Methods Twenty four adult male rats were divided randomly into four equal groups: 1- normal saline (control), 2- dexamathasone 0.125 mg/kg/day, i.m., 3- dexamathasone + niacin 200 mg/kg/day, oral gavages, 4- niacin. After 2 weeks, serum total c...
[ 2 ] - Effect of xylazine and yohimbine on the phasic pain during the estrous cycle in the rat
The aim of the present study was to investigate the effect of α2-adrenergic agonist (xylazine) andantagonist (yohimbine) on phasic pain during estrous cycle in female rats. Adult female rats weighing 180-220 g were kept under controlled temperature (21-24°C) and light/dark conditions (light on at 6:00 a.m. and light off at 6:00 p.m.). Animals were divided into four groups: 1) control group whic...
[ 3 ] - اثرات متقابل امواج الکترومغناطیس و تعدیل گیرنده GABA-B بر غلظت تستوسترون سرمی در موشهای صحرایی پرخاشگر
Introduction: The aim of the present study is to investigate the effect of interaperitoneal injection of baclofen (GABA-B agonist) and CGP35348 (GABA-B antagonist) on serum testosterone concentration in aggressive rats exposed to electromagnetic field. Methods: Fifty five mature male rats weighing 200±20 grams were studied. Animals were divided into 2 main groups and four subgroups. Main grou...
[ 4 ] - Evaluation of the GABAA receptor on pain sensitivity in male rat pretreated with Valeriana officinalis extract using formalin test
Introduction: : It seems that Valeriana officinalis (valerian) extract through gamma-amino-butyric acid A (GABAA) receptor possesses analgesic effect. The aim of the present study was to investigate the effect of muscimol and picrotoxin on pain sensitivity in male rats pretreated with valerian extract using the formalin test. Methods: Thirty-five male rats weighing 200-250g in standard temp...
[ 5 ] - Can ovariectomy and learning affect prefrontal cortex GABAAα1 receptor distribution in passive avoidance model in rats?
Introduction: The interaction between steroid hormones and neurotransmitters such as GABA has been proved. The regulation of muscimol binding to high-affinity GABAA receptors by estradiol and progesterone has been studied within distinct brain regions using in vitro quantitative autoradiography. There are few studies about the mechanism of the effect of steroid hormones on behaviors such as ...
[ 6 ] - Effect of acute exposure to ethanol on distribution of NR1 subunit of NMDA receptor of glutamate in cerebral cortex of chick embryo
Introduction: There is considerable evidence that glutamate-mediated excitatory neurotransmission plays an important role in mediating the behavioral actions of acutely administered ethanol. The aim of the present study was to investigate the effect of acute ethanol exposure on NR1 subunit of NMDA (n-methyl-d-aspartate) receptor distribution in the cerebral cortex of chick embryo on the 10th...
[ 7 ] - Effect of butylated hydroxytoluene on passive avoidance learning in male rats
Introduction: Butylated hydroxytoluene (BHT 2, 6-di-tert-butyl-p-cresol) is one of the extensively used antioxidants in the food industry. It is used in low-fat foods, fish products, packaging materials, paraffin, and mineral oils. BHT is also widely used in combination with other antioxidants such as BHA, propyl gallate, and citric acid for the stabilization of oils and high-fat foods. On t...
[ 8 ] - Effect of muscimol and picrotoxin injection in am and ac nucleus of amygdala on aggressive behavior
Introduction: Aggressive behavior is a major issue in the field of mental health. Pharmacotherapy is often used for the treatment of violent individuals. A neurochemical system most consistently linked with aggression is the GABAergic system. The aim of the present investigation was to examine the effect of muscimol (GABAA agonist) 250 and 500 ng/rat and picrotoxin (GABAA antagonist) 1.5 and...
[ 9 ] - Effect of intracerebroventicular injection of baclofen and CGP35348 on pain sensitivity during estrous cycle
Introduction: In female rats sensitivity to antinociceptive treatment varies during estrous cycle stages. The role of GABA through GABAB receptor in nociception has been established. The aim of the present study is to investigate the effect of intercerebroventicular injection of GABAB receptor agonist (baclofen) and GABAB antagonist (CGP35348) on pain sensitivity during different stages of estr...
[ 10 ] - Neuroprotective Effect of Zataria Multiflora Essential Oil on Rats With Alzheimer Disease: A Mechanistic Study
Introduction: Finding herbs with promising effects to prevent or postpone Alzheimer Disease (AD) is highly demanded. The present study aimed at clarifying plausible effects and related mechanism(s) of Zataria Multiflora Essential Oil (ZMEO) against memory impairment in a rat model of the AD. Methods: Forty male adult rats were categorized into four groups and treated as follows: 1. The Negativ...
[ 11 ] - Interactive effect of aqueous-alcoholic extract of ginger as well as GABAA receptor agonist and antagonist on pain sensitivity in male rats
Introduction: Ginger has shown anti-nociceptive effects. Here we investigated the possible involvement of GABAA receptors in anti-nociceptive effect of ginger using muscimol (GABAA agonist) and picrotoxin (GABAA antagonist) in rats that received ginger. The pain sensitivity was evaluated by formalin test. Methods: Thirty-five male Sprague-Dawley rats were randomly divided into 7 groups (n=5): s...
[ 12 ] - Zataria multiflora could improve hippocampal tau protein and TNFα levels and cognitive behavior defects in a rat model of Alzheimer's disease
Objective: Zataria multiflora (ZM) is a plant with ethnopharmacological value which was recently tested to reduce symptoms of Alzheimer’s disease (AD). The aim of the present study was to determine the effect of ZM essential oil on spatial cognitive and noncognitive behavior, as well as hippocampal tau protein and tumor necrosis factor alpha (TNFα) concentrations in ra...
[ 13 ] - Hippocampal GABAA Receptor and Pain Sensitivity during Estrous Cycle in the Rat
Background: Estradiol and progesterone as well as hippocampal GABAA receptors are believed to play a role in the modulation of pain. The aim of present study was to investigate the effect of intrahippocampal injections of GABAA receptor agonist (muscimol) and GABAA receptor antagonist (picrotoxin) on pain sensitivity during estrous cycle. Methods: Pain sensitivity was evaluated in rats ...
[ 14 ] - Effects of Pretreatment With Ginseng Extract on Dopamine D2 Receptor Analgesi
Introduction: The ginseng extract is an herb that has been used for many purposes such as analgesic effect. Dopamine D2 receptors are involved in the regulation of pain in humans. Therefore, the present investigation aims to study how pretreatment with aqueous-alcoholic extract of ginseng can affect dopamine D2 receptors’ pain sensitivity. Methods: We used 45 adult male rats weighing 250±20 fo...
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