Mohammad Mehdi Aslani

[ 1 ] - Screening, Cloning and Expression of Active Streptokinase from an Iranian Isolate of S.equisimilis Group C in E. coli

[ 2 ] - Identification and Characterization of a High Vancomycin-Resistant Staphylococcus aureus Harboring VanA Gene Cluster Isolated from Diabetic Foot Ulcer

Objective(s) Staphylococcus aureus is a common cause of human infection, and emergence of vancomycin-resistance S. aureus  is a great concern for treatment of methicillin-resistant S. aureus,(MRSA) in recent years (MRSA). Here, we report the isolation of high-level VRSA. Materials and Methods S. aureus was isolated from foot ulcer of a diabetic woman in Tehran, Iran. Antibiotic susceptibilit...

[ 3 ] - Genetic Diversity and Drug Resistance of Helicobacter pylori Strains in Isfahan, Iran

Objective(s) Resistance to antimicrobial agents, particularly metronidazole and clarithromycin, is frequently observed in Helicobacter pylori and may be associated with treatment failure. This resistance rate varies according to the population studied. The aim of this study was to assess the pattern of antimicrobial resistance of H. pylori isolates from dyspeptic patients in Isfahan. Material...

[ 4 ] - تایپینگ مولکولی سویه‌های کلستریدیوم دیفیسیل جدا شده از بیماران بستری به روش PCR-Ribotyping

Abstract Background: Clostridium difficile infection (CDI) has been a major growing problem in hospitals in recent years. Detection of the source of Clostridium difficile strains is of importance for the control of the nosocomial spread of this microorganism. This study was done to identify C.difficile isolates by polymerase chain reaction, (PCR), ribotyping. Materials and methods: The descript...

[ 5 ] - تشخیص ملکولی و تعیین فاکتورهای ویرولانس سویه‌های سودوموناس آئروجینوزا جدا شده از عفونتهای زخم و سوختگی

سابقه و هدف: در دهه‌های اخیر در پی درمان آنتی‌بیوتیکی، سودوموناس آئروجینوزا به عنوان یکی از مهمترین پاتوژنهای بیمارستانی شناسایی شد. به دلیل اهمیت کلینیکی سودوموناس آئروجینوزا روشهای متنوعی برای شناسایی آن به وجود آمده است. هدف از این مطالعه شناسایی سویه‌های سودوموناس آئروجینوزا جدا شده از عفونتهای زخم و سوختگی بر اساس PCR ژن‌های اختصاصی لیپوپروتئینهای غشای خارجی (oprI و (oprLو اگزوتوکسین A (to...

[ 6 ] - Cloning, expression, purification and the study of immunotherapy status of TGFαL3-SEB chimeric protein in breast cancer treatment

Background & Aim: Bacterial superantigens, stimulate polyclonal T cells irrespective of their antigen specificity, resulting in a massive release of cytokines from T cells and monocytes, and suggest that that they could be candidates of new antitumor agents. Recent attempts have been done to specifically target superantigens towards tumors. Here, we evaluate TGFαL3-SEB fusion protein as a new a...