Saeed Emami

[ 1 ] - Synthesis and In Vitro Cytotoxic Activity of Novel Chalcone-Like Agents

Objective(s): Chalcones and their rigid analogues represent an important class of small molecules having anticancer activities. Therefore, in this study the synthesis and cytotoxic activity of new 3-benzylidenchroman-4-ones were described as rigid chalcone analogues. Materials and Methods: The reaction of resorcinol with 3-chloropropionic acid in the presence of CF3SO3H was a...

[ 2 ] - 2-Amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles as New Cytotoxic Agents

A series of 2-amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) as a catalyst at room temperature. Mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. The cytotoxic activity of target compounds were evaluated against t...

[ 3 ] - 2-Amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles as New Cytotoxic Agents

A series of 2-amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) as a catalyst at room temperature. Mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. The cytotoxic activity of target compounds were evaluated against t...

[ 4 ] - سنتز، بررسی اثرات سیتوتوکسیک و مطالعه داکینگ دو مشتق ایندول-چالکون

Background and purpose: Chalcones are promising lead for anticancer drug design and discovery. Chalcones with different mechanisms including tubulin polymerization inhibition induce apoptosis in cancer cells. The aim of current work was synthesis of two indole-chalcone derivatives and investigation of their cytotoxic activity against cancer and normal cell lines, as well as molecular docking st...

[ 5 ] - کاربرد آریل‌آزول‌ها و آزول‌های با حلقه جوش‌ خورده در طراحی ترکیبات جدید ضدلیشمانیا

Leishmaniasis is a group of tropical diseases with high worldwide prevalence and difficulty in management. At present, the development of resistance and the increase of co-infected leishmaniasis with AIDS have become a serious public health problem. Thus, designing and discovery of effective and non-toxic drugs for the treatment of this disease is very urgent. Azole derivatives have displayed a...

[ 6 ] - مروری بر چالکون‌های ضد سرطان القاکننده آپوپتوز

Cancer is a complex and life-threatening disease involving uncontrollable cell proliferation, evading apoptosis, and metastasis. Despite recent developments in cancer chemotherapy, there are no effective broad spectrum anticancer agents that could selectively target cancer cells. Thus, designing and discovering new efficient and selective anticancer agents are urgent needs. It is important that...

[ 7 ] - سنتز مشتقات کنژوگه از سیپروفلوکساسین و ایزاتین به منظور دستیابی به ترکیبات جدید سیتوتوکسیک

Background and purpose: In recent years, the incidence of cancers has increased in the world. Therefore, many researches have focused on new strategies for treatment of cancers. Previous studies showed that quinolone antibacterials can inhibit human topoisomerases at high concentrations and can be considered as potential cytotoxic agents. On the other hand, 5,7-dibromoisatin is a cytotoxic agen...

[ 8 ] - مروری بر نقش محافظتی ترکیبات پلی فنلی (رسوراترول، کوئرسیتین و کورکومین) بر عملکرد میتوکندری قلب

Mitochondria plays a major role in maintaining homeostasis of heart cells. Mitochondria produce ATP and is the main intracellular source of reactive oxygen species (ROS) which can cause oxidative damage. Free oxygen radicals and oxidative damage are associated with cardiovascular pathology. Antioxidant defense can play an essential role in preventing oxidative damage by controlling free oxygen ...