Alireza Khoshnevisan
Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
[ 1 ] - Feasibility assessment of in vitro chemoresponse assay on stereotactic biopsies of glioblastoma multiforms: a step towards personalized medicine
Objective(s):P In vitro chemosensitivity and resistance assays (CSRAs) are a promising tool for personalized treatment of glioblastoma multiform (GBM). These assays require a minimum of 1 to 2 g of tumor specimen for testing, but this amount is not always accessible. We aimed to assess the feasibility and validity of utilizing stereotactic biopsies of GBM in CSRAs. Materials and Methods: Single...
[ 2 ] - An overview of therapeutic approaches to brain tumor stem cells
Primary and secondary malignant central nervous system (CNS) tumors are devastating invasive tumors able to give rise to many kinds of differentiated tumor cells. Glioblastoma multiform (GBM), is the most malignant brain tumor, in which its growth and persistence depend on cancer stem cells with enhanced DNA damage repair program that also induces recurrence and resists current chemo- and radi...
[ 3 ] - لیپوم ناحیه تکتوم مغز میانی: گزارش موردی و مرور مقالات
Background: Intracranial lipomas are rare benign neoplasms that comprise 1% of all primary brain tumors. Generally, occur in midline structure and usually identified incidentally on CT scans or in autopsies. The incidence of intracranial lipomas is about 0.08 to 0.46% on autopsies. These benign lesions are slow-growing, usually asymptomatic and rarely require surgery. Case Presentation: We r...
[ 4 ] - مطالعه میزان آنژیوژنز مدلهای زنوگرافت بومی گلیوبلاستوما مالتیفورم در بیماران ایرانی بهروش MVD-CD34
Background: Despite advances in cancer diagnosis and treatment, survival rate of patients suffering from glioblastoma multiform (GBM) has not been significantly improved. Therefore, novel therapeutic adjuncts to routine therapies have been suggested over time. Inhibition of angiogenesis by antiangiogenic drugs is one of the new approaches to inhibit the growth of malignant cells. Microvessel d...
[ 5 ] - طبقهبندی پتانسیلهای عمل نرونی با استفاده از شبکههای عصبی شعاعی
Background: Studying the behavior of a society of neurons, extracting the communication mechanisms of brain with other tissues, finding treatment for some nervous system diseases and designing neuroprosthetic devices, require an algorithm to sort neuralspikes automatically. However, sorting neural spikes is a challenging task because of the low signal to noise ratio (SNR) of the spikes. The mai...