Bernard Burke
Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, LE1 9HN, UK
[ 1 ] - Human activated macrophages and hypoxia: a comprehensive review of the literature
Macrophages accumulate in poorly vascularised and hypoxic sites including solid tumours, wounds and sites of infection and inflammation where they can be exposed to low levels of oxygen for long periods. Up to date, different studies have shown that a number of transcription factors are activated by hypoxia which in turn activate a broad array of mitogenic, pro-invasive, pro-angiogenic, and pro...
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