Mohammad Khaksari
Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
[ 1 ] - Estrogen provides neuroprotection against brain edema and blood brain barrier disruption through both estrogen receptors α and β following traumatic brain injury
Objective(s):Estrogen (E2) has neuroprotective effects on blood-brain-barrier (BBB) after traumatic brain injury (TBI). In order to investigate the roles of estrogen receptors (ERs) in these effects, ER-α antagonist (MPP) and, ER-β antagonist (PHTPP), or non-selective estrogen receptors antagonist (ICI 182780) were administered. Materials and Methods: Ovariectomized rats were divided into 10 gr...
[ 2 ] - The effects of cyclooxygenase inhibitors on the gastric emptying and small intestine transit in the male rats following traumatic brain injury
Objective(s):This study was carried out to investigate the effects of COX-2 selective inhibitor (Celecoxib) or non-selective COX inhibitor (Ibuprofen) on gastrointestinal motility. Materials and Methods: The rats were randomly divided into five groups including: intact, sham, traumatic brain injury (TBI) group (intact rats under TBI), Celecoxib group (10 mg/kg), Ibuprofen group (10 mg/kg). Rats...
[ 3 ] - The Effects of Female Sex Steroids on Gastric Secretory Responses of Rat Following Traumatic Brain Injury
Objective(s) Gastric ulceration is induced by various forms of stress like surgery, ischemia and trauma. The female sex has more resistance to stress and the gastrointestinal lesions happen fewer than male sex. The purpose of this study was to evaluate the role of estradiol and progesterone on the gastric acid and pepsin levels following traumatic brain injury (TBI) induction. Materials and M...
[ 4 ] - اسیدهای چرب امگا-3 و بهبودی زخم در دیابت
سابقه و هدف: اسیدهای چرب امگا-3, یکی از چربی‌های بدن انسان می‌باشد که به فراوانی در ماهی یا روغن ماهی وجود دارد و دارای اثرات بالقوه فراوانی در تعدیل بیماری‌های مختلف، خصوصاً بیماری دیابت قندی است. نارسایی ترمیم زخم یکی از شایع‌ترین عوارض مزمن بیماری دیابت است، که عوامل مختلفی در پیدایش این نارسایی نقش دارند. با توجه به اثرات ضدالتهابی و عروقی که برای روغن ماهی مطرح است, این روغن ممکن است بسیار...
[ 5 ] - اثر نیفدیپین و وراپامیل بر نارسایی عروقی دیابت مزمن تجربی در موش صحرایی
سابقه و هدف: شروع تأخیری عوارض دیابت می‌تواند از تغییرات عروقی، منشاء بگیرد. کلسیم نقش مهمی در القاء و شروع مرحله‌ای که منجر به آسیب عروقی و افزایش نفوذپذیری عروق می‌شود، بازی می‌کند. هدف این مطالعه این بود که مشخص نماید آیا مسدود کننده‌های کانال کلسیم (نیفدیپین و وراپامیل) می‌توانند از نفوذپذیری عروق جلوگیری نمایند؟ مواد و روش‌ها: این مطالعه مداخله‌ای – تجربی بر روی موش‌های صحرایی نر بالغ انج...
[ 6 ] - اکواپورین 4 و نقش محافظتی استروئیدهای جنسی بر آسیب مغزی ناشی از تروما در موش صحرایی ماده
Background and Objectives: The brain damage caused by trauma is the most common cause of death. The neuroprotection effects of estrogen and progesterone have been reported in numerous studies. In the present study, the role of different doses of sex steroids has been investigated on the aquaporin 4 protein concentration changes in brain tissue of ovariectomized (OVX) rats after traumatic brain ...
[ 7 ] - اثر توأم تمرین استقامتی و عصاره آبی زیره کوهی بر چربی‌های پلاسما در موش‌های سوری نر هیپرکلسترولمیک
Background and Objectives: The effect of endurance training on lipid profile and cardiovascular endurance in normal rat after Bunium Persicum Extract (BPE) administration has been previously investigated. In the present study, the effect of co-administration of endurance training and persicum extract on plasma lipid and lipoproteins in hypercholesterolemic male mice was examined. Materi...
[ 8 ] - ارزیابی مقادیر مس، مولیبدن و چربی های سرم در شاغلین واحد مولیبدن مجتمع مس سرچشمه کرمان
¯چکیده زمینه : مس و مولیبدن عناصر کمیاب و ضروری هستند که بر متابولیسم چربی ها تأثیر می گذارند. هدف : مطالعه به منظور ارزیابی سطح سرمی مس و مولیبدن و ارتباط آن با غلظت چربی های سرم در کارگران معدن مس سرچشمه کرمان انجام شد. مواد و روش ها : این مطالعه تحلیلی- مقطعی در سال 1380 بر روی سه گروه 40 نفری انجام شد. گروه مورد، کارگران واحد مولیبدن بودند که تماس زیادی با مس و مولیبدن داشتند. گروه شاهد او...
[ 9 ] - P 14: CSF NGF/IL-6 Ratio: a Useful Marker for the Evaluation of Progesterone Efficacy in Traumatic Brain Injury
Introduction: Following our previous studies on the neuroprotective effects of progesterone and cytokines such as IL-6 (IL-6) is involved in the inflammatory response, to examine whether changes in IL-6 and Nerve grows factor(NGF) concentrations in CSF can responsible for the neuroprotective effects of progesterone after traumatic brain injury(TBI). Materials and Methods: Female ovariectomized ...
[ 10 ] - P 19: The Effects of Aloe Vera Extract on Brain Edema and Blood-Brain Barrier Permeability after Traumatic Brain Injury
Introduction: Recent studies have reported that the Aloe vera (Aloe barbadensis miller) plant has anti-inflammatory and antioxidant effects. This study evaluated the neuroprotective effects of different doses of Aloe vera extract after traumatic brain injury (TBI) in male rats. Materials and Methods: In this study, 70 male rats were divided into 2 groups; each group consists of 5 of sub-g...
[ 11 ] - تغییرات ادم مغزی و پیامدهای نورولوژی بعد از ضربه‌ی مغزی تجربی با مصرف توأم استروژن وپروژسترون
مقدمه: مطالعه‌های زیادی نشان داده‌اندکه خیز (ادم) مغزی کنترل نشده علت بسیاری از ناتوانی‌ها و مرگ و میرها در ضربه‌ی مغزی است. مطالعه‌های قبلی اثر محافظت‌کنندگی مصرف تنهای استروژن و پروژسترون را در ضربه مغزی نشان داده‌اند. در این مطالعه اثر مصرف توأم استروژن و پروژسترون به دنبال ضربه‌ی مغزی منتشر بر خیز مغزی و پیامد نورولوژی آن در موش‌های صحرایی ماده بررسی شده است. مواد و روش‌ها: این پژوهش مداخله...
[ 12 ] - The Effects of Estrogen Receptors' Antagonist on Brain Edema, Intracranial Pressure and Neurological Outcomes after Traumatic Brain Injury in Rat
Background: In previous studies, the neuroprotective effect of 17&beta-estradiol in diffuse traumatic brain injury has been shown. This study used ICI 182,780, a non-selective estrogen receptor antagonist, to test the hypothesis that the neuroprotective effect of 17&beta-estradiol in traumatic brain injury is mediated by the estrogen receptors. Methods: The ovariectomized rats were divided into...
[ 13 ] - Decrease in blood flow and temperature of rat knee joint by calcium
Introduction: The Blood flow increases in the inflamed joint induced by Complete Freund’s Adjuvant (CFA). Since the anti-inflammatory effect of calcium channel blockers have been shown in pervious studies, the present study investigates the role of these blockers on the blood flow and temperature (inflammation indices) in inflamed knee joint induced by CFA. Methods: This experimental study wa...
[ 14 ] - Downregulation of Matrix Metalloproteinases 2 and 9 is Involved in the Protective Effect of Trehalose on Spinal Cord Injury
Upregulation of matrix metalloproteinases (MMPs), in particular MMP-2 and MMP-9 contributes to secondary pathogenesis of spinal cord injury (SCI) via promoting inflammation. Recently, we reported that trehalose suppresses inflammatory responses following SCI. Therefore, we investigated the effect of trehalose on MMP-2 and MMP-9 expression in SCI. A weight-drop contusion SCI was induced in male ...
[ 15 ] - Effect of Estrogen and Progesterone on Cytokines Levels at Different Time Intervals after Traumatic Brain Injury
Introduction: Following a traumatic brain injury (TBI), the excessive release of proinflammatory cytokines is major cause of cerebral edema that can cause permanent neuronal loss. This study examined the changes in brain concentrations of proinflammatory cytokines IL-1, IL-6, TNF-α and TGF- after different doses of estrogen or progesterone treatment in brain-injured rats at 6 and 24 h post...
[ 16 ] - Effect of shilajit on the levels of pro-inflammatory and anti inflammatory cytokines in ulcerative colitis induced by acetic acid in male rats
Background: The levels of IL-13, IL-4, IL-1B, TNF-α and IL-10 alter in the colon of people with ulcerative colitis. previous studies, it was found that shilajit (asphaltum) was effective in the improvement of ulcerative colitis.we guessed that the shilajit has been able to improve the ulcerative colitis by affecting the amount of cytokines. Objective: The aim of the present study was to investi...