Shahin Yazdani
Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
[ 1 ] - MicroRNAs that target RGS5
Objective(s):An earlier meta-analysis on gene expression data derived from four microarray, two cDNA library, and one SAGE experiment had identified RGS5 as one of only ten non-housekeeping genes that were reported to be expressed in human trabecular meshwork (TM) cells by all studies. RGS5 encodes regulator of G-protein signaling-5. The TM tissue is the route of aqueous fluid outflow, and is r...
[ 2 ] - تزریق داخل زجاجیه‌ای Bevacizumab در مبتلایان به گلوکوم نورگ‌زایی
هدف: تعیین اثر تزریق داخل زجاجیه‌ای Bevacizumab (IVB) در بیماران مبتلا به گلوکوم نورگ‌زایی (NVG). روش پژوهش: مطالعه به روش کارآزمایی بالینی تصادفی‌شده بر روی 26 چشم از 26 بیمار مبتلا به NVG انجام شد. بیماران پس از انجام درمان‌های رایج به دو گروه تقسیم شدند: گروه درمان (14 چشم) که تحت IVB به میزان 5/2 میلی‌گرم در سه نوبت به فاصله زمانی 4 هفته قرار گرفتند و گروه شاهد (12 چشم) که با فواصل زمان...
[ 3 ] - Discovery of Novel Peptidomimetics for Brain-Derived Neurotrophic Factor using Phage Display Technology
Brain-Derived Neurotrophic Factor (BDNF) is a neuroprotectant candidate for neurodegenerative diseases. However, there are several clinical concerns about its therapeutic applications. In the current study, we selected BDNF-mimicking small peptides from phage-displayed peptide library as alternative molecules to the clinical challenges. The peptide library was screened against BDNF receptor (Ne...