Ali Akbar Nekooeian
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
[ 1 ] - Acute and chronic effects of lithium on BDNF and GDNF mRNA and protein levels in rat primary neuronal, astroglial and neuroastroglia cultures
Objective(s):Theneuroprotective effect of lithium has been attributed to its therapeutic action. However, the role of glial cells particularly astrocytes, and the possible interactions between neurons and astrocytes in neuroprotective effects of lithium have been disregarded. Thus, the aim of this study was to evaluate the direct effects of lithium on brain derived neurotrophic factor (BDNF) an...
[ 2 ] - Chronology of blood pressure changes in renal hypertension induced by solid plexiglass clips in the rat
The objective of this study was to determine the chronology of changes in blood pressure in renalhypertension induced by solid plexiglass clips in rats. Saw blades with the thickness of 0.21-0.22 mm wereused to make clips sized 4 × 2 × 2 mm from a piece of 2-mm thick plexiglass. Rats were subjected to shamoperation or left renal arterial clipping, and 1, 2, 3 and 4 weeks later blood pressure, a...
[ 3 ] - چگونه یک مقاله علمی بنویسیم؟
نوشتن مقاله علمی یکی از چالش‌های دستیاران، اساتید و محققان بالینی است، بخصوص اگر آموزش مقاله‌نویسی ندیده باشند. لازمه مقاله‌نویسی توانایی در دو بعد می‌باشد: توانایی علمی که نشان دهنده سطح دانش و تسلط نویسنده به موضوع تحقیق، و هنر مقاله‌نویسی که عبارت از توانایی در نگارش صحیح فارسی یا انگلیسی، توانایی در انتخاب محتوای مقاله و توانایی در نحوه کنار هم گذاشتن محتویات برای ایجاد یک مقاله می‌باشد. هر...
[ 4 ] - Effects of Camphor on Sexual Behaviors in Male Rats
According to Iran’s folk medicine, camphor, a crystalline ketone obtained from essential oils of Cinnamomum camphora, has both sexual behavior attenuating and enhancing properties. This study examined the effects of camphor on sexual behavior in male rats. Twenty four sexually mature male Sprague-Dawley rats were randomly divided into 4 groups receiving daily i.p. injections of oliv...
[ 5 ] - The Antiinfluenza Virus Activity of Hydroalcoholic Extract of Olive Leaves
The influenza viruses are major etiologic agents of human respiratory infections, and inflict a sizable health and economic burden. This study examines the antiinfluenza virus activity of hydroalcoholic extract of olive leaves (OLHE). Olive leaves were collected from gardens around the city of Shiraz, characterized, dried, ground to powder, and its hydroalcoholic extract was prepared. The ...
[ 6 ] - The Effects of Resveratrol in Rats with Simultaneous Type 2 Diabetes and Renal Hypertension: a Study of Antihypertensive Mechanisms
Background: Resveratrol has beneficial effects on cardiovascular system. This study aimed at examining antidiabetic and antihypertensive effects of resveratrol in rats with simultaneous type 2 diabetes and renal hypertension.Methods: Eight groups (8-10 each) of male Spargue-Dawley rats, including a control, a diabetic (induced by streptozotocin and nicotinamide), a renal hypertensive (induced b...
[ 7 ] - Effects of Pomegranate Seed Oil on Insulin Release in Rats with Type 2 Diabetes
Background: Pomegranate seed oil and its main constituent, punicic acid, have been shown to decrease plasma glucose and have antioxidant activity. The objective of the present study was to examine the effects of pomegranate seed oil on rats with type 2 diabetes mellitus. Method: Six groups (n=8 each) of male Sprague-Dawley rats, comprising a control, a diabetic (induced by Streptozocin and Nico...
[ 8 ] - Effects of Short-term Renovascular Hypertension and Type 2 Diabetes on Cardiac Functions in Rats
Background: The cardiac effects simultaneously occurring during experimental hypertension and diabetes have rarely been investigated. This study aimed at examining the effects of short-term renovascular hypertension and type 2 diabetes on cardiac functions. Methods: Five groups (7 each) of male Sprague-Dawley rats, including a control group, a diabetes (induced by Streptozocin and Nicotinamide)...
[ 9 ] - Increased bcl-2 Protein Levels in Rat Primary Astrocyte Culture Following Chronic Lithium Treatment
Background: B cell CLL/lymphoma 2 protein, bcl-2, is an important anti-apoptotic factor that has been implicated in lithium’s neuroprotective effect. However, most studies have focused on assessing the effects of lithium in neurons, ignoring examination of bcl-2 in astrocytes, which also influence neuronal survival and are affected in bipolar disorder. The aim of this study was to evaluate whet...
[ 10 ] - Antihypertensive Effects of Hydroalcoholic Extract of Crataegus Azarolus Subspecies Aronia Fruit in Rats with Renovascular Hypertension: An Experimental Mechanistic Study
Background: Hawthorn species decreases blood pressure and relaxes precontracted vessels. This study aimed at examining the antihypertensive effect and related mechanisms of hydroalcoholic extract of Crataegus azarolus subspecies aronia fruit in rats with renovascular hypertension.Methods: Six groups of male Sprague-Dawley rats, each containing 6 to 8 rats, were studied. The groups comprised of ...
[ 11 ] - Design, implementation, and evaluation of principles of writing biomedical research paper course
Introduction: Graduate (PhD) students in medical sciences, who will formfuture faculties and investigators in Iran’s Universities of Medical Sciences, are not trained on scientific writing during their training. The present study describes the design, implementation, and evaluation of Principles of Writing Biomedical Research Paper course.Methods: The course, prepared based on an extensive sear...
[ 12 ] - The Healing Effects of Hydroalcoholic Extract of Carum Copticum L. on Experimental Colitis in Rats
Background: Ulcerative colitis is an inflammatory disease with indefinite treatment. The present study aimed to assess the anti-inflammatory and antioxidant effects of Carum copticum L. (CC) extract on induced colitis in rats. Methods: Sixty male rats were randomly divided into six groups (n=10 per group). Acetic acid-induced colitis rats were orally administered with doses of 100, 200, a...
[ 13 ] - Liposomal and Non-Liposomal Formulations of Vitamin C: Comparison of the Antihypertensive and Vascular Modifying Activity in Renovascular Hypertensive Rats
Background: Liposomes constitute a promising drug delivery vehicle, and are believed to improve drugs’ effectiveness. This study was aimed to compare antihypertensive and vascular modifying activities of liposomal and non-liposomal forms of ascorbic acid. Methods: Forty-nine male Sprague-Dawley rats were randomly divided into seven groups (n=7): A sham vehicle-receiving (Sham-veh), hypert...
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