Gholamhasan Vaezi
Department of Biology, Damghan Branch, Islamic Azad University, Semnan, Iran
[ 1 ] - Hypoglycemic and hypolipidemic activities of Salvia hydrangea in streptozotocin-induced diabetes in rats
Objective(s): This study was to investigate the potential anti-diabetic effects of alcoholic extract of Salvia hydrangea in rats. Materials and Methods:Thirty five male Wistar rats were divided into five groups namely non-diabetic control, diabetic control, and three experimental diabetic that received either Salvia hydrangea extract for 21 days at the doses of 100 and 200 or glibenclamide at ...
[ 2 ] - مقایسه ی اثر آنتی‌اکسیدانی چای بادرنجبویه- دارچین و چای قره قات- دارچین بر استرس اکسیداتیو کارگران پتروشیمی
Introduction: This study was carried out to compare the antioxidative effects of Melissa officinalis - Cinnamomum tea and Vaccinium myrtillus - Cinnamomum tea. Methods: This is a clinical trial performed on 50 petrochemical workers who were exposed to mercury. They were randomly divided into two groups of 25. After taking written informed consents, 5 ml venous blood was collected from each ...
[ 3 ] - بررسی اثر زرد چوبه (Curcuma longa ) بر بلوغ آزمایشگاهی تخمک‌های نارس موش نژاد NMRI و تکوین جنین‌های حاصل از آن
Background and purpose: Herbal medicine have always been used in Iran and other countries around the world. They have different effects on human body, some are beneficial and others could be detrimental. There are few studies that investigated the effect of turmeric (Curcuma Longa) on female reproduction. This study examined the effect of turmeric extract on in vitro maturation of mice’s ...
[ 4 ] - اثر عصاره خارشتر (Alhagi camelorum) بر فاکتورهای عملکردی کبد و کلیه در موش‌های نر دیابتی‌شده با استرپتوزوتوسین
بیماری دیابت یکی از شایع‌ترین بیماری های متابولیک می‌باشد و در طولانی مدت تأثیرات وسیعی بر تمامی اندام‌های بدن از جمله کبد و کلیه می‌گذارد. هدف پژوهش حاضر اثر عصاره الکلی بخش‌های هوایی گیاه خارشتر بر تست‌های عملکردی کبد و کلیه در موش‌های نر دیابتی شده با استرپتوروتوسین می‌باشد. در این مطالعه 28 موش نر ویستار به 4 گروه (7n=) تقسیم شدند: گروه کنترل غیر دیابتی با رژیم غذایی نرمال ، گروه کنترل دیاب...
[ 5 ] - Swertia longifolia Boiss has beneficial effects on hepatic and renal functions in diabetic rats
Introduction: Diabetes is a multifactorial syndrome with high prevalence which may induce serious disorders in the body organs like the liver and kidney. This study aimed to compare the effects of the alcoholic extract of the aerial parts of Swertia longifolia Boiss on blood glucose, lipid profiles and liver and kidney function tests in streptozotocin-induced diabetes. Methods: Thirty five male...
[ 6 ] - مقایسه اثرات حاد و مزمن تزریق 1- (3-کلروفنیل) پیپیرازین و میانسرین بر خمیازه و نعوظ آلت تناسلی در موش‌های صحرایی
اهداف: خمیازه‌کشیدن یک رفتار فیلوژنتیک و مسری است که همراه با کشش یا نعوظ آلت تناسلی در پستانداران، پرندگان و خزندگان تحت شرایط مختلف مشاهده می‌شود. هدف این پژوهش، تعیین اثرات تزریق حاد و مزمن 1- (3-کلروفنیل) پیپیرازین و میانسرین بر خمیازه و نعوظ آلت تناسلی در موش‌های صحرایی نر بالغ بود. مواد و روش‌ها: در این مطالعه تجربی، 30 سر موش صحرایی نر نژاد ویستار با وزن 300-250گرم به‌طور تصادفی به سه گر...
[ 7 ] - بررسی اثر ویتامین E روی میزان باروری موش های بزرگ نر آزمایشگاهی(RAT)در بی وزنی شبیه سازی شده (Experimental study)
Abstract Introduction: Physiology of reproduction is very complex and many factors influence on animal infertility.Today, researchers simulate weightlessness physiology for investigation about space biology. The best successful model for microgravity physiology simulation on the floor is in the rat hind-limb suspenion .The aim of this study is evaluation and comparision of the effect of v...
[ 8 ] - The effect of hydroalcoholic extract of Ziziphora clinopodioides L. on spatial memory and neuronal density of hippocampal CA1 region in rats with sporadic Alzheimer's disease
Objective: Alzheimer's disease is a neurodegenerative disorder associated with gradual loss of cognitive and memory abilities. It was shown that the hippocampus is one of the first structures in the brain that is affected by the disease. Ziziphora clinopodioides<span style="font-size: mediu...
[ 9 ] - Obestatin inhibits apoptosis and astrogliosis of hippocampal neurons following global cerebral ischemia reperfusion via antioxidant and anti-inflammatory mechanisms
Objective(s): Obestatin is a newly discovered peptide with antioxidant activities in different animal models. Recent studies have shown that Obestatin inhibits apoptosis following cardiac ischemia/reperfusion injury. Brain ischemia/reperfusion induces irreversible damage especially in the hippocampus area. This study aimed at examining the protective impact of Obestati...
[ 10 ] - Effect of Intracerebroventricular Morphine Withdrawal on the Anxiety Behavior in Male Rats Reared in Social Isolation
Aims: Prescription of narcotics has controversial effects on the occurrence of anxiety processes. On the other hand, the social isolation has been caused due to the drug consumption, but its acute and chronic effects on behavioral differences are not obvious in the process of dependency and withdrawal. The present study aimed to investigate effects of acute and chronic intracerebroventricular M...
[ 11 ] - Myelin Protection by Ursolic Acid in Cuprizone-Induced Demyelination in Mice
Neuronal survival in multiple sclerosis (MS) and other demyelinating diseases depends on the preservation of myelin and remyelination of axons. Myelin protection is the main purpose to decrease myelin damage in the central nervous system (CNS). Ursolic acid (UA) as a natural product in apple is suggested to protect neural cells. This study is the first to demonstrate an effect for UA on CNS mye...
[ 12 ] - Myelin Protection by Ursolic Acid in Cuprizone-Induced Demyelination in Mice
Neuronal survival in multiple sclerosis (MS) and other demyelinating diseases depends on the preservation of myelin and remyelination of axons. Myelin protection is the main purpose to decrease myelin damage in the central nervous system (CNS). Ursolic acid (UA) as a natural product in apple is suggested to protect neural cells. This study is the first to demonstrate an effect for UA on CNS mye...
[ 13 ] - Effect of Melatonin on Serum Levels of INF-1β and Vitamin B12 in Patients With Multiple Sclerosis: A Randomized Controlled Trial
Background: Multiple Sclerosis (MS) is a chronic autoimmune disease due to the demyelination of axons in the central nervous system. Melatonin, as a hormone with potential anti-inflammatory effects, can reduce the MS symptoms by altering the levels of inflammatory mediators. Methods: In this study, 50 MS patients referred to the MS Society in Markazi Province were randomly selected. Each patie...
[ 14 ] - The Comparison of Green Tea Aqueous Extract and Catechin Effect on Pituitary-Gonadal Axis in Rat Models of Type 1 Diabetes
Background and Objective: Diabetes causes fertility disorders by interfering with the endocrine gland function. There are reports that, green tea and catechins could have anti-oxidant and hypoglycemic properties. Therefore, in the present study, we evaluated the effects of green tea aqueous extract and catechin influence on pituitary-gonadal axis in rat models of type 1 diabetes. Materials & M...
[ 15 ] - Biomarker efficacy in multiple sclerosis diagnosis and treatment
The goal in studies concerning biomarkers in autoimmune diseases is finding a marker which fluctuates in correlation with the disease’s severity and settles within normal borders after effective treatment. This marker would later be used as an efficient tool in diagnosis and analysis of medicine clout. It seems the most cogent biomarkers are those measurable in serum or plasma. MS is a neurolog...
[ 16 ] - The role of Artemisia turanica extract on renal oxidative and biochemical markers in STZ-induced diabetes in rat
Objective: The aim of the current study was to investigate the protective effect of Artemisia turanica (AT) against diabetes- induced renal oxidative stress in rats. Materials and Methods: Fifty male Wistar rats were randomly divided into five groups: control, STZ-induced diabetic rats, diabetic rats+ metformin, diabetic rats + AT extract, diabet...
[ 17 ] - تحلیل و بررسی اثر داروی کربوپلاتین بر روی اووژنز (تخمک گذاری) و تغییرات رحمی در موش ماده بالغ نژاد NMRI در شرایط In vivo
سرطان یکی از بیماری های شایع در سراسر دنیا می باشد. از مهمترین روش های درمانی برای سرطان شیمی درمانی است که به وسیله رژیم های دارویی مختلفی انجام می گیرد. یکی از داروهای رایج در شیمی درمانی «کربوپلاتین» است. هدف از این کار تحقیقاتی بررسی تاثیر داروی کربوپلاتین برروی تخمک زایی و تغییرات رحمی در موش نژاد NMRI است. در این پژوهش 30 سر موش به پنج گروه کنترل، شم و سه گروه تجربی تقسیم شدند. داروی کربو...
[ 18 ] - The Effect of 6-Gingerol on Growth Factors and Apoptosis Indices in Rats Exposed to Gold Nanoparticles
Introduction: Research has shown that gold nanoparticles (AuNPs) can damage the physiological processes of brain tissue. Given the antioxidant properties of gingerol (GING), this study aimed to determine the protective effect of 6-gingerol on hippocampal levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), DNA oxidative damage, and the amount of Bax and Bcl2 apoptosis ...
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