Shahin Ahmadian
Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
[ 1 ] - Inhibitory effect of corcin on aggregation of 1N/4R human tau protein in vitro
Objective(s):Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. One of the hallmarks of AD is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. In this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in AD and tauopathies. Unfortunately, the available syntheti...
[ 2 ] - Immunocytochemical Study on Microtubule Reorganization in HL-60 Leukemia Cells Undergoing Apoptosis
Background: Microtubules (MT) are important components of cell cytoskeleton and play key roles in cell motility mitosis and meiosis. They are also the targets of several anticancer agents which indicating their importance in maintaining cell viability. Microtubular reorganization contributing to apoptotic morphology occurs in normal and neoplastic cells undergoing apoptosis induced by cytotoxic...
[ 3 ] - The Effects of Extremely Low Frequency Pulsed Electromagnetic Field on Collagen Synthesis of Rat Skin: a Biochemical and Histoligical Approach
The efficacious effects of pulsed electromagnetic field (PEMF) under the certain field parameters like frequency and the field intensity have been reported for various tissue and molecules. Since collagen is found abundantly in most tissue structures, this research was designed to further investigate the effects of extremely low frequency (ELF) PEMF on the synthesis of the epidermal collagen. ...
[ 4 ] - Ultrastructural Study of Rotavirus Replication and Localization of the Intermediate Capsid Protein VP6
Rotavirus, a triple-layered non-enveloped member of the Reoviridae family, obtained a transient membrane envelope when newly synthesized subviral particles bud into the endoplasmic reticulum (ER). As rotavirus particles mature, they lose their transient membrane and obtain outer layer. It is mostly believed that only double layered particles bud into the ER. The present study describes that the...
[ 5 ] - بررسی اثر محافظتی پلی فنول رزوراترول بر روی انسجام غشاء میتوکندری در برابر حدواسط های الیگومری پروتئین لیزوزیم سفیده تخم مرغ
نتایج حاصل از مطالعات انجام شده در سال های اخیر نشان می دهد که گونه های الیگومری، به عنوان حدواسط های سمی در روند تشکیل تجمعات آمیلوئیدی، از طریق افزایش نفوذپذیری غشاهای بیولوژیک منجر به مرگ سلولی می شوند. در این بین غشاء میتوکندری از اهمیت به سزائی برخوردار است به گونه ای که اختلال در عملکرد میتوکندری ویژگی بارز بسیاری از بیماری های مرتبط با تجمع پروتئین هاست. در نتیجه به منظور برر...
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