Marjan Nassiri-Asl Nassiri-Asl
Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran|Department of Pharmacology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
[ 1 ] - In vivo anti-Toxoplasma activity of aripiprazole
Objective(s):There are supportive evidences about the possible role of latent Toxoplasma. gondii infections on the behavior and neurologic functions, such as increased dopamine levels in the brain. The aim of this study was to examine anti-toxoplasma activity of aripiprazole that is an atypical anti-psychotic drug in mice. Materials and Methods: Mice were randomly divided into four groups, inc...
[ 2 ] - Report of severe menorrhagia following the maximum amount of lamotrigine overdose
Lamotrigine is an antiepileptic drug used as a treatment for partial and generalised seizures as well as for bipolar disorder type I. Till date, very few cases of lamotrigine overdose have been reported. The spectra of clinical effects of lamotrigine in acute overdose are not well established. In severe cases of poisoning, serious effects such as coma, respiratory depression, recurrent seizures...
[ 3 ] - Report of severe menorrhagia following the maximum amount of lamotrigine overdose
Lamotrigine is an antiepileptic drug used as a treatment for partial and generalised seizures as well as for bipolar disorder type I. Till date, very few cases of lamotrigine overdose have been reported. The spectra of clinical effects of lamotrigine in acute overdose are not well established. In severe cases of poisoning, serious effects such as coma, respiratory depression, recurrent seizures...
[ 4 ] - مروری بر سلول های بنیادی مزانشیمی و کاربرد بالقوه آن ها در طب بازساختی
سلول های بنیادی سلول های غیراختصاصی هستند که علاوه بر دارا بودن خاصیت خود نوسازی، توانایی تمایز به انواع سلول های دیگر را دارند. در واقع سلول های بنیادی تحت تأثیر شرایط فیزیولوژیک یا آزمایشگاهی خاص قادر هستند به سلول هایی با عملکردهای اختصاصی مانند سلول های عضلانی قلب، سلول های عصبی، استئوبلاست، آدیپوسیت، کندروسیت و ... تبدیل شوند. در بین سلول های بنیادی، سلول های بنیادی مزانشیمی ...
[ 5 ] - The Effects of Kainic Acid-Induced Seizure on Gene Expression of Brain Neurotransmitter Receptors in Mice Using RT2 PCR Array
Introduction: Kainic acid (KA) induces neuropathological changes in specific regions of the mouse hippocampus comparable to changes seen in patients with chronic temporal lobe epilepsy (TLE). According to different studies, the expression of a number of genes are altered in the adult rat hippocampus after status epilepticus (SE) induced by KA. This study aimed to quantitatively evaluate changes...
[ 6 ] - Effect of rutin on oxidative DNA damage in PC12 neurons cultured in nutrients deprivation condition
Objective(s): Rutin is a flavonoid with potent antioxidant property, which exhibited cytoprotective effects in several models of neuronal injury. This work aimed to examine whether rutin can protect neurons against oxidative DNA damage caused by serum/glucose deprivation (SGD) as an in vitro model of neurodegeneration and ischemia. Materials and Metho...