Mehdi Sadegh
Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
[ 1 ] - Repeated injections of orexin-A developed behavioral tolerance to its analgesic effects in rats
Objective(s):Reduction of pharmacological effectiveness or tolerance appears following repeated administration of many analgesic drugs. We investigated tolerance to anti-nociceptive effects of orexin-A, an endogenous potent analgesic peptide using the hot-plate test.Materials and Methods:Orexin-A was microinjected ICV (intracerebroventricular) with an interval of 12 hr for 7 continuous days and...
[ 2 ] - بررسی اثر تحمل دارویی ناشی از مصرف مزمن مرفین و سالیسیلات بر شکل پذیری سیناپسی
Background & Aim: Salicylates and opioids are widely used in chronic pain relief. Chronic use of these drugs reorganizes synaptic function, especially experience-dependent plasticity in brain regions. Therefore, in this study the effects of chronic administration of salicylate and morphine on synaptic plasticity were investigated. Methods: in this review, Elsevier, Science Direct, PubMed and G...
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