Alireza Biglari
Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
[ 1 ] - Recombinant fibromodulin has therapeutic effects on diabetic nephropathy by down-regulating transforming growth factor-β1 in streptozotocin-induced diabetic rat model
Objective(s):Diabetic nephropathy is an important long-term complication of diabetes mellitus which appears to be partially mediated by an increase in secretion of transforming growth factor-β (TGF-β). Fibromodulin, the small leucine-rich proteoglycan, has been proposed to be the potent TGFβ1 modulator. In this study, the therapeutic effects of recombinant adenoviral vectors expressing fibromod...
[ 2 ] - بررسی تولید دانش توسط پژوهشگران دانشگاه علوم پزشکی زنجان در پایگاههای اطلاعاتی Web of Science، Pubmed، Scopus، و Magiran طی سالهای 1380-1393
Background and Objective: Several Studies indicate ascended scientific productivity of Iran in all academic fields including medical sciences universities. The aim of this study was to figure out scientific production by researchers of Zanjan University of Medical Sciences from March 2001 to March 2015. Materials and Methods: This research was a descriptive study in which data wa...
[ 3 ] - Evaluation of Relationship between Awareness of Islamic Citizenship Rights and Organizational Similar-to-me of Education Managers of Zanjan University of Medical Sciences
Background & Objectives: This research aimed to determine the relationship between awareness of Islamic citizenship rights and organizational similar-to-me of education managers of Zanjan University of Medical Sciences, Zanjan, Iran. Materials and Methods: This descriptive and correlational research was performed on all education department managers and faculty members with a history of educat...
[ 4 ] - Effect of let-7a overexpression on the differentiation of conjunctiva mesenchymal stem cells into photoreceptor-like cells
Objective(s): MicroRNAs (miRNAs) could regulate many cellular processes such as proliferation and differentiation. let-7a miRNA is one of the key regulators in the developmental transition of retinal progenitor cells into differentiated cells. Current evidence suggests that mesenchymal stem cells (MSCs) can isolate from various tissues such as bone marrow and conjuncti...
[ 5 ] - Whole Exome Sequencing Revealed a Novel GJB1 Pathogenic Variant and a Rare BSCL2 Mutation in Two Iranian Large Pedigrees with Multiple Affected Cases of Charcot-Marie-Tooth
Charcot-Marie-Tooth disease (CMT) is the most common hereditary neuropathy of the peripheral nervous system with a wide range of severity and age of onset. CMT patients share similar phenotypes which make it often impossible to identify the disease types based on clinical presentation and electrophysiological studies alone. In recent years, novel genetic diagnostic approaches such as whole exom...
[ 6 ] - Lentiviral Mediated Expression of Soluble Neuropilin 1 Inhibits Semaphorin 3A-mediated Collapse Activity in Vitro
Introduction: Semaphorin 3A (Sema 3A) is a secreted protein, which plays an integral part in developing the nervous system. It has collapse activity on the growth cone of dorsal root ganglia. After the development of the nervous system, Sema 3A expression decreases. Neuropilin 1 is a membrane receptor of Sema 3A. When semaphorin binds to neuropilin 1, the recruitment of oligodendrocyte precurso...
[ 7 ] - Valproic Acid Ameliorates Locomotor Function in the Rat Model of Contusion via Alteration of Mst1, Bcl-2, and Nrf2 Gene Expression
Background: As a novel pro-apoptotic kinase, Mammalian sterile 20–like kinase 1 (Mst1) promotes programmed cell death in animal models of inflammatory diseases. This research aimed to determine the level of expression of Mst1 gene in a rat model of spinal cord injury (SCI) treated with valproic acid (VPA). Methods: Animals were divided into four groups: Contused animals (untreated); laminectom...
[ 8 ] - The Frequency of Consanguinity and Its Related Factors in Parents of Children with Genetic Disorders
Background and Objective: Consanguinity increases the incidence of genetic disorders. The frequency of consanguinity varies in different societies. There was no data regarding the frequency of consanguinity in Zanjan province. This study aimed to describe the prevalence of consanguineous unions in the parents of children with genetic disorders and its related factors in Zanjan, Iran. Materials...
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