Nematollah Ahangar
Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
[ 1 ] - Hypothermic activity of acetaminophen; Involvement of GABAA receptor, theoretical and experimental studies
Objective(s):The mechanism of hypothermia action of acetaminophen (APAP) remains unclear even 125 years after its synthesis. Acetaminophen produces hypothermia. The mechanism of this reduction in core body temperature is not clear but evidence shows that it is not dependent on opioid and cannabinoid receptors. Because of strong documents about the roles of GABA and benzodiazepine receptors in h...
[ 2 ] - Study of Antidepressant and Sedative-HypnoticActivity of Hydroalcoholic Extract of Asperugo procumbens L. Aerial Parts in Mice
Asperugo procumbens L. has been used in Iranian traditional medicine for the refreshing, tranquillizing and mood elevating activities. The present study was undertaken to evaluate the antidepressant and sedative-hypnotic potential of acute administration of the hydroalcoholic extract of this plant in mice. Additionally, the effects of flumazenil on the hypnotic activity of the extracts were eva...
[ 3 ] - Study of Antidepressant and Sedative-HypnoticActivity of Hydroalcoholic Extract of Asperugo procumbens L. Aerial Parts in Mice
Asperugo procumbens L. has been used in Iranian traditional medicine for the refreshing, tranquillizing and mood elevating activities. The present study was undertaken to evaluate the antidepressant and sedative-hypnotic potential of acute administration of the hydroalcoholic extract of this plant in mice. Additionally, the effects of flumazenil on the hypnotic activity of the extracts were eva...
[ 4 ] - بررسی فراوانی ژنوتیپ های حذف شده گلوتاتیون اس- ترانسفراز در یک جمعیت سالم استان مازندران T و 1 M1
Background and purpose: Glutathion S-transferase (GSTs) are a family of detoxification phase II enzymes that catalyze the conjugation of carcinogenic and cytotoxic componds with glutathion. GSTs are polymorphic and deletion of GSTM1 and GSTT1 polymorphism is caused by lack of enzyme production that lead to loss of antioxidant activity. In this study, we examined the frequency of GSTM1 and G...
[ 5 ] - بررسی فراوانی پلی مورفیسم ژنتیکی (C4326G) Leu432Val ژن 1B1CYP در یک جمعیت سالم استان مازندران
Background and purpose: CYP1B1 is involved in the metabolism of exogenous and endogenous substrates and plays a key role in hormone and xenobiotic induced carcinogenesis. Polymorphisms in CYP1B1 could result in modifications in its enzyme activity and are known to be associated with cancer susceptibility related to environmental toxins and hormone exposure. Moreover, the association of CYP1B1 p...
[ 6 ] - Study of sex differences in the expression of β-actin gene in various tissues of the rat
Introduction: Beta-actin is a housekeeping gene, which is used as an internal standard in various biological studies. Recently, it was reported that the expression of commonly used housekeeping genes including ß–actin changes in disease states or under certain experimental conditions. Based on the reports about the effects of sex hormones on the expression of the ß- actin gene, in this study...
[ 7 ] - بررسی خطاهای دارویی در بخش های داخلی بیمارستان امام سجاد(ع) رامسر در بهار و تابستان 1396
مقدمه اشتباهات دارویی رخداد شایع بالقوه خطرناک است که میتواند در سیستم درمان به عنوان یکی از چالشها و معیارهای سنجش ایمنی بیمار مورد استفاده قرار گیرد.در این مطالعه، برخی از خطاهای رایج دارویی در بخشهای داخلی بیمارستان امام سجاد (ع) رامسر، مورد بررسی قرار گرفت. روش کار نوع مطالعه توصیفی- مقطعی و جامعه مورد مطالعه شامل200پرونده بیمار بستری ...
[ 8 ] - Antinociceptive and Anti-Inflammatory Effects of Geum iranicum Khatamsaz Methanol Extract in Mice
Background and objectives:Traditionally, Geum species from Rosaceae family have been used for treating inflammatory disorders. Geum iranicum Khatamsaz is endemic to Iran. The aim of this study was to investigate the antinociceptive and anti-inflammatory activities of Geum iranicum methanol extract G. iranicum methanol extract using classical ...
[ 9 ] - Antidiabetic Activity of Aqueous Seed Extract of Securigera securidaca in Streptozotocin Induced Diabetic Rats
Background & Objective: Securigera securidaca is a medicinal plant used in Persian folk medicine to decrease blood sugar. Nevertheless, there is some controversy about its effects. The current study investigated the hypoglycemic activity of the aqueous seed extract of S. securidaca. Materials & Methods: Sixty mature male Charles-River rats were categorized and divided randomly into 10 groups w...
[ 10 ] - بررسی آگاهی و نگرش در مورد زردی نوزادی در مادران نوزادان متولد شده در بیمارستان شهید رجایی تنکابن
خلاصه مقدمه زردی نوزادی به علت افزایش بیلی روبین در 50 درصد نوزادان ترم و 80 درصد نوزادان پره ترم دیده می شود. باتوجه به عوارض خطرناک این بیماری، ارجاع به موقع نوزاد در موثر بودن تشخیص و درمان به موقع وپیشگیری از عوارض زردی نوزادان که وابسته به آگاهی و نگرش مناسب مادران در این زمینه است، بسیار مهم است. لذا این مطالعه با هدف بررسی آگاهی...
[ 11 ] - بررسی مصرف منطقی داروهای مسکن تزریقی در بخش های اورژانس و جراحی بیمارستان امام سجاد (ع) رامسر
مقدمه: هدف از انجام پژوهش حاضر بررسی الگوی مصرف منطقی داروهای مسکن تزریقی اعم از اپیوئید و غیر اپیوئید در بیماران بستری در بخش های جراحی و اورژانس بیمارستان امام سجاد رامسر بوده است. روش کار: این مطالعه به شکل توصیفی و گذشته نگر، در بهار و تابستان 1395، بر روی 1181 پرونده بیماران دریافت کننده داروی مسکن تزریقی بستری شد...
[ 12 ] - Role of rs4149056 Polymorphism of SLCO1B1 Gene in Myopathy Caused by Atorvastatin in Cardiovascular Patients in West of Mazandaran Province
Background and purpose: Statins are among the most widely used drugs in treatment of cardiovascular diseases. Reducing the side effects of these drugs is of great importance in preventing treatment failure. The aim of this study was to investigate the role of rs4149056 polymorphism in statin-induced myopathy in patients with cardiovascular diseases in West of Mazandaran province, Iran. Materia...
[ 13 ] - Evaluating the effect of medical honey and stapler on skin graft fixation in burn wounds: A Randomized clinical Trial
Background: One of the uses of honey is related to wound healing. A stapler normally connects the skin graft to the underlying tissue. Due to its high cost, lack of production in the country, and causing physical damage to the tissue, an alternative option is needed. Objective: This study aimed to determine the effect of using medical honey compared to staplers in attaching skin grafts to burn...
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