Gholamhossein Yousefi
Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran|Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran
[ 1 ] - Comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities
Objective(s): Comparative in vivo studies were carried out to determine the adsorption characteristics of amitriptyline (AMT) on activated charcoal (AC) and sodium polystyrene sulfonate (SPS). AC has been long used as gastric decontamination agent for tricyclic antidepressants and SPS has showed to be highly effective on in-vitro drugs adsorption. Materials and Methods: Sprague-Dawley male rats...
[ 3 ] - Meloxicam transdermal delivery: effect of eutectic point on the rate and extent of skin permeation
Objective(s):Drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. Analgesics such as NSAIDs have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. Meloxicam is one of NSAIDs with no topical form in the market. In this research, we attempted to quantify the skin permeation of a m...
[ 4 ] - Physicochemical and Immunomodulatory Properties of Gum Exudates Obtained from Astragalus myriacanthus and Some of Its Isolated Carbohydrate Biopolymers
Plants gums are complex mixtures of different polysaccharides with a variety of biological activities and pharmaceutical applications. Few studies have focused on physicochemical and biological properties of gums obtained from different plants. This study was designed to determine potential pharmaceutical and pharmacological values of the gum exudates and its isolated biopolymers obtained from ...
[ 5 ] - Physicochemical and Immunomodulatory Properties of Gum Exudates Obtained from Astragalus myriacanthus and Some of Its Isolated Carbohydrate Biopolymers
Plants gums are complex mixtures of different polysaccharides with a variety of biological activities and pharmaceutical applications. Few studies have focused on physicochemical and biological properties of gums obtained from different plants. This study was designed to determine potential pharmaceutical and pharmacological values of the gum exudates and its isolated biopolymers obtained from ...
[ 6 ] - مهاجرت دی متیل فتالات و دی بوتیل فتالات در گلاب بستهبندی شده در ظروف پلی‌اتیلن ترفتالات
سابقه و هدف: پلی‌اتیلن ترفتالات PET (Poly ethylene terephthalate) از پرکاربردترین ظروف در صنعت بستهبندی و غذا است. با وجود ویژگیهای مناسب، ترکیبات موجود در ساختار بسپار ممکن است به داخل ماده‌ی غذایی مهاجرت کنند که تجمع این مواد در بدن انسان سبب بروز مشکلاتی در سلامتی می گردد. مواد و روش‌ها: 27 نمونه یک لیتری گلاب تهیه شد و در دماهای 4، 25 و C˚42 و زمان‌های 2 روز، 2 هفته و 2 ماه، میزان مهاجرت...
[ 7 ] - Pharmacokinetics and Biodistribution of Pegylated Methotrexate after IV Administration to Mice
The efficacy of methotrexate (MTX) as an antimetabolite chemotherapeutic agent highly depends on its blood circulation half-life. In our previous study, different conjugates of MTX (MTX-PEG) were synthesized, their physicochemical properties were investigated and MTX-PEG5000 was finally selected as optimum drug-conjugate for further investigations. In the current work, first the stability of MT...
[ 8 ] - Pharmacokinetics and Biodistribution of Pegylated Methotrexate after IV Administration to Mice
The efficacy of methotrexate (MTX) as an antimetabolite chemotherapeutic agent highly depends on its blood circulation half-life. In our previous study, different conjugates of MTX (MTX-PEG) were synthesized, their physicochemical properties were investigated and MTX-PEG5000 was finally selected as optimum drug-conjugate for further investigations. In the current work, first the stability of MT...
[ 9 ] - Sublingual versus Vaginal Misoprostol for the Induction of Labor at Term: A Randomized, Triple-Blind, Placebo-Controlled Clinical Trial
Background: We sought to compare the effectiveness and safety of sublingual versus vaginal misoprostol for the termination of pregnancy with a live full-term fetus.Methods: This randomized, triple-blind, placebo-controlled clinical trial was performed on 200 primiparous women with normal, singleton, full-term pregnancies candidated for the induction of labor. Sublingual and vaginal tablets cont...
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