Akram Jamshidzadeh

[ 1 ] - Comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities

Objective(s): Comparative in vivo studies were carried out to determine the adsorption characteristics of amitriptyline (AMT) on activated charcoal (AC) and sodium polystyrene sulfonate (SPS). AC has been long used as gastric decontamination agent for tricyclic antidepressants and SPS has showed to be highly effective on in-vitro drugs adsorption. Materials and Methods: Sprague-Dawley male rats...

[ 2 ] - Human Placental Extract Ameliorates Structural Lung Changes Iinduced by Amiodarone in Rats

Amiodarone is used in treatment of cardiac arrhythmias. Therapeutic use of amiodarone is limited by its side effects, including pulmonary toxicity. Human Placenta Extract (HPE) contains a variety of bio-active substances. Thus, the present study aimed to quantitatively evaluate the protective effects of HPE on the structural lung changes induced by amiodarone using stereological methods. Spragu...

[ 3 ] - Study of the Effects of ATP Suppliers and Thiol Reductants on Toxicity of Pioglitazone in Isolated Rat Liver Mitochondria

Pioglitazone (PG) is one of thiazolidinediones used for the treatment of type II diabetes mellitus. Some reports of its hepatotoxicity exist, but the mechanism of its hepatotoxicity is not well known. In the present study, the protective effect of some ATP suppliers are investigated against mitochondrial toxicity of PG in isolated rat mitochondria. Mitochondrial viability was investigated by MT...

[ 4 ] - Human Placental Extract Ameliorates Structural Lung Changes Iinduced by Amiodarone in Rats

Amiodarone is used in treatment of cardiac arrhythmias. Therapeutic use of amiodarone is limited by its side effects, including pulmonary toxicity. Human Placenta Extract (HPE) contains a variety of bio-active substances. Thus, the present study aimed to quantitatively evaluate the protective effects of HPE on the structural lung changes induced by amiodarone using stereological methods. Spragu...

[ 5 ] - Study of the Effects of ATP Suppliers and Thiol Reductants on Toxicity of Pioglitazone in Isolated Rat Liver Mitochondria

Pioglitazone (PG) is one of thiazolidinediones used for the treatment of type II diabetes mellitus. Some reports of its hepatotoxicity exist, but the mechanism of its hepatotoxicity is not well known. In the present study, the protective effect of some ATP suppliers are investigated against mitochondrial toxicity of PG in isolated rat mitochondria. Mitochondrial viability was investigated by MT...

[ 6 ] - بررسی اثر حفاظت کبدی گیاه شاتره در سمیت ناشی از CCl4 بر روی موش صحرایی

مقدمه: شاتره از گیاهانی است که در طب سنتی ایران در درمان بیماری‌های مختلف کبدی مطرح بوده است، در این تحقیق اثر حفاظتی این گیاه بر روی سمیت ناشی از تتراکلریدکربن بر روی کبد موش صحرایی مورد بررسی قرار گرفت. هدف: از آنجایی‌که در کشور ما عوامل دارویی محافظت‌کننده کبدی کمتر در دسترس بوده و از طرفی بیماری‌های کبدی ناشی از عواملی همچون هپاتیت ویروسی و داروها تاحدی شایع است، لازم گردید تا از گیاهان د...

[ 7 ] - Comparative Measurement of Serum Acetyl Cholinesterase Enzyme Using Three Different Methods

Introduction: IAChE (acetylcholinesterase) is one of the plasma’s enzymes that plays a crucial role in nervous signal transduction in synapses and is responsible for the hydrolysis of Ach. Material & Method: We investigated three methods for the determination of AChE in human blood serum, using three different assays. Michel methods are based on the measurement of hydrogen ion produced in pro...

[ 8 ] - Comparison between Alpha and Calendula for healing of third-degree burn in rats

In this study, we compared the effects of Calendula and Alpha ointment in the treatment of burn wounds and compare its results with silver sulfadiazine (SSD). Seventy-five male Sprague-Dawley rats were divided into five groups, and similar burn ulcers were produced on anterior surface of thigh of rats. The first group of rats no treatment was applied, base gel was applied topically to group II,...

[ 9 ] - Hepatoprotective Effect of Pomegranate (Punica Granatum) Fruit Juice and Seed Extracts against CCL4-Induced Toxicity

Punica granatum is used as a medicinal plant, and its fruit concentrate has been used for the prevention and treatment of liver diseases in Iran. The effects of different concentrations of the hydroalcoholic, ethyl acetate and n-hexane extracts of the Punica granatum (fruit juice and seed) were investigated against CCl4- induced cytotoxicity in HepG2...

[ 10 ] - The Effects of Topical Sildenafil on Wound Healing in Rat

Nitric oxide (NO) is an important molecule synthesized during wound repair. Studies have reported the use of NO donors on cutaneous wound repair, but their effects in different phases of healing are not elucidated. The aim of this work was to investigate the effects of topical sildenafil on wounds in rats. Sildenafil (25 mg) was topically applied once daily on wound in treatment groups. On...

[ 11 ] - Effects of Camphor on Sexual Behaviors in Male Rats

According to Iran’s folk medicine, camphor, a crystalline ketone obtained from essential oils of Cinnamomum camphora, has both sexual behavior attenuating and enhancing properties. This study examined the effects of camphor on sexual behavior in male rats. Twenty four sexually mature male Sprague-Dawley rats were randomly divided into 4 groups receiving daily i.p. injections of oliv...

[ 12 ] - Pharmacognostic and Anti-Inflammatory Properties of Securigera securidaca Seeds and Seed Oil

Background and objectives: Although weed plants are considered undesirable in a particular situation, some weed seeds can be a valuable and cheap source of therapeutic natural compounds. Securigera securidaca (L.) Degen & Dorfl (Fabaceae) is widely distributed in Europe, Australia and Asia as a weed plant. This study investigated the bioactive compounds of S. secur...

[ 13 ] - اثر ترمیمی‌گیاه کلپوره (Teucrium polium L.) بر کولیت ناشی از استیک اسید در موش بزرگ آزمایشگاهی نر

چکیده زمینه و هدف: بیماری التهابی روده(IBD)، به صورت حالت مزمن در روده با علل ناشناخته شامل عوامل مختلف ایمنی، ژنتیکی و محیطی می‏باشد. امروزه در سراسر دنیا، بسیاری از ترکیب‌های گیاهی و تولیدی به عنوان فرآوردههای ضدالتهاب استفاده می‏شود. هدف از این مطالعه، بررسی تأثیر ضدالتهابی عصاره آبی گیاه کلپوره Teucrium poliumL. بر کولیت در موش بود. روش بررسی: در این مطالعه تجربی، 135 سر موش بزرگ آزما...

[ 14 ] - Effect of Lycopene on Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats

Background: Cylophosphamide is used alone or in combination with other drugs for treatment of neoplastic diseases. Hemorrhagic cystitis is a major potential toxicity and dose limiting side effect of cyclophosphamide. The aim of this study was to evaluate the effects of lycopene compared with some antioxidants for the prevention of cyclophosphamide induced hemorrhagic cystitis in rats. Methods: ...