Behzad Baradaran
Immunology Research Center, Tabriz University of Medical Science, Tabriz, Iran
[ 1 ] - Up-regulation of TLR2 and TLR4 in high mobility group Box1-stimulated macrophages in pulpitis patients
Objective(s): High Mobility Group Box1 (HMGB1) is a nonhistone, DNA-binding protein that serves a crucial role in regulating gene transcription and is involved in a variety of proinflammatory, extracellular activities. The aim of this study was to explore whether HMGB1 stimulation can up-regulate the expression of Toll-like Receptor 2 (TLR2) and Toll-like Receptor 4 (TLR4) on macrophages from p...
[ 2 ] - Gene therapy based on interleukin-12 loaded chitosan nanoparticles in a mouse model of fibrosarcoma
Objective(s): Interleukin-12 (IL-12) as a cytokine has been proved to have a critical role in stimulating the immune system and has been used as immunotherapeutic agents in cancer gene therapy. Chitosan as a polymer, with high ability of binding to nucleic acids is a good candidate for gene delivery since it is biodegradable, biocompatible and non-allergenic polysaccharide. The objective of the...
Co-Authors