Ali Reza Khalatbary
Molecular and Cell Biology Research Center, Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
[ 1 ] - Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat
Objective(s): Oxidative stress has a pivotal role in the pathogenesis of diabetic retinopathy (DR). Juglans regia L. (JRL) leaf extract has hypoglycemic and antioxidative properties. This study aimed to determine the ameliorative effects of JRL against diabetic retinopathy. Materials and Methods: The DR rat model was generated by injection of streptozotocin (STZ). A subset of the diabetic rats ...
[ 2 ] - Effects of Epigallocatechin Gallate on Tissue Lipid Peroxide Levels in Traumatized Spinal Cord of Rat
Objective(s) Recent studies revealed the neuroprotective effects of epigallocatechin gallate (EGCG) on a variety of neural injury .The purpose of this study was to determine the effects of EGCG on the tissue lipid peroxidation after spinal cord injury (SCI). Materials and Methods Rats were randomly divided into four groups of 7 rats each as follows: sham-operated group, trauma group, and EGC...
[ 3 ] - Immunohistochemical and Electron Microscopic Study of the Inhibitory Effects of Olive Oil Polyphenol on Dexamethasone-Induced Apoptosis
Background: There is accumulating evidence that a polyphenol present in olive oil, oleuropein, has antioxidant, anti-inflammatory and anti-apoptotic effects. This study aimed at determining the anti-apoptotic effect of Oleuropein (Ole) on dexamethasone-induced apoptosis of mouse thymocytes. Method: Mice ...
[ 4 ] - Hepatoprotective and Hypolipidemic Effects of Satureja Khuzestanica Essential Oil in Alloxan-induced Type 1 Diabetic Rats
In the present study, we examined the antioxidative activities of Satureja khuzestanica essential oil (SKE) and possible protective effect of SKE on lipid profile, atherogenic index and liver enzyme markers in Alloxan-induced Type 1 diabetic rats. Thirty male rats were randomly divided into three groups; group one as control, group two diabetic untreatment, and group three treatments with SKE b...
[ 5 ] - Hepatoprotective and Hypolipidemic Effects of Satureja Khuzestanica Essential Oil in Alloxan-induced Type 1 Diabetic Rats
In the present study, we examined the antioxidative activities of Satureja khuzestanica essential oil (SKE) and possible protective effect of SKE on lipid profile, atherogenic index and liver enzyme markers in Alloxan-induced Type 1 diabetic rats. Thirty male rats were randomly divided into three groups; group one as control, group two diabetic untreatment, and group three treatments with SKE b...
[ 6 ] - تعدیل سیستم ایمنی توسط اپی‌گالوکتکین‌گلیت در بخش ضایعه دیده نخاع موش صحرایی
چکیده مقدمه: تحریک پاسخ‌های ایمنی پس از بروز ضایعه نخاعی، موجب آسیب ثانویه در همان بخش ضایعه دیده نخاع می‌شود. هدف: بررسی پتانسیل خواص تعدیل‌کنندگی پاسخ‌های ایمنی توسط اپی‌گالوکتکین‌گلیت در ضایعات نخاعی موش صحرایی مواد و روش‌ها: در این مطالعه سه گروه 7تایی موش صحرایی نر بکار رفتند: گروه کنترل منفی(فقط لامینکتومی)، گروه کنترل مثبت (پس از ضایعه نخاعی، تزریق سرم فیزیولوژی) و گروه تجربی(پس از ضای...
[ 7 ] - ارتباط بین الگوی غذایی با عوارض نوروپاتی در بیماران دیابتی: یک مطالعه مقطعی
Background and purpose: Diabetes mellitus is one of the most common metabolic diseases and neuropathy is one of the main complications of diabetes. Modification of eating habit is the most effective and most economical way in prevention of diabetic complications. This research aimed at studying the relationship between food habits and diabetic neuropathy. Materials and methods: This cross-se...
[ 8 ] - آپوپتوز در بیماری‌های نورودژنراتیو
بیماری‌های نورودژنراتیو موجب بروز دامنه وسیعی از اختلالات نورولوژیک در سیستم عصبی مرکزی می‌گردد. امروزه محققین بر نقش محوری آپوپتوز در بیماری‌های نورودژنراتیو تاکید فراوان دارند. با توجه به محدودیت‌های موجود در توانایی ترمیم سیستم عصبی مرکزی آسیب دیده، کاهش آسیب‌های وارده از طریق مهار مرگ سلول‌های عصبی بسیار حائز اهمیت است. در دهه‌های اخیر پیشرفت‌های قابل توجهی در زمینه شناخت فرایند آپوپتوز در ...
[ 9 ] - Protective Role of Oleuropein against Acute Deltamethrin- Induced Neurotoxicity in Rat Brain
Background: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, leading to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. The purpose of this study was to determine the anti-apoptotic effect of OE pretreatment in the neuronal cells of cerebral cortex. Methods: Rats were randomly divided into four groups each containin...
[ 10 ] - Effect of Oleuropein on Tissue Myeloperoxidase Activity in Experimental Spinal Cord Trauma
Background: Neutrophil infiltration plays an important role in inflammatory reactions following spinal cord injury (SCI) and these cells cause substantial secondary tissue damage. The purpose of this study was to determine the effect of oleuropein (OE) on myeloperoxidase (MPO) activity as an index of neutrophil infiltration. Methods: Rats were randomly divided into four groups of 7 rats each as...
[ 11 ] - Anti-Inflammatory Effect of the Epigallocatechin Gallate Following Spinal Cord Trauma in Rat
Background: Spinal cord injury (SCI) stimulates an inflammatory reaction that causes substantial secondary damage inside the injured spinal tissue. The purpose of this study was to determine the anti-inflammatory effects of epigallocatechin gallate (EGCG) on traumatized spinal cord. Methods: Rats were randomly divided into four groups of 12 rats each as follow: sham-operated group, trauma group...
[ 12 ] - A Comparative Study of Therapeutic Benefits of Intraspinal and Intravenous Bone Marrow Stromal Cell Administration to Spinal Cord Injuries
Background: Recent reports demonstrated that intravenous route as a minimally invasive method, similar to direct injection, is suitable for bone marrow stromal cell (BMSC) transplantation. In this study, we made a comparison of intraspinal and intravenous route of BMSC administration to repair injured spinal cord tissue. Methods: Six groups of adult female rats were used in this study. Laminect...
[ 13 ] - Bone marrow stromal cells and their application in neural injuries
Background: This article reviews experimental and clinical studies in which neural injuries repaired with bone marrow stromal cells. History: Bone marrow contains two kinds of stem cells: hematopoietic and nonhematopoietic (stromal) stem cell. In vitro studies indicate that bone marrow stromal cells have the capacity of differentiation into other cells (such as neural cell) under treatment wit...
[ 14 ] - The Study of Intracellular Energy in Apoptotic Cells
Khalatbary AR1, Tarihi T2, Naderimanesh H3 1. Assistant Professor, Department of Anatomy, Faculty of Medicine, Lorestan University of Medical Sciences 2. Professor, Department of Anatomy, Faculty of Medicine, Ttarbiat Modarres University , Tehran 3. Professor, Department of Biophysics, Faculty of Basic Sciences, Tarbiat Modarres University , Tehran Abstract Background: Apoptosis is an active ...
[ 15 ] - Oleuropein Attenuates Deltamethrin-induced Apoptosis in Rat Cerebellar Purkinje Neurons
Background: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, and lead to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. This study aimed at determining the DM toxicity and anti-apoptotic effect of OE pretreatment in cerebellar Purkinje neurons. Materials and Methods: Rats were randomly divided into four groups a...
[ 16 ] - اختلالات عضلانی اسکلتی و ارتباط آن با فرسودگی شغلی در پرستاران: یک مطالعه توصیفی تحلیلی
مقدمه: پرستاران به دلیل وضعیت کار و فشارهای روانی که در محیط کار متمحل می‌شوند، در معرض ریسک ابتلا به اختلالات عضلانی اسکلتی بوده و این عوامل می‌تواند در بروز فرسودگی شغلی این افراد مؤثر باشد. مطالعه حاضر با هدف بررسی اختلالات عضلانی اسکلتی و ارتباط آن با فرسودگی شغلی در پرستاران انجام شد. روش کار: مطالعه حاضر از نوع توصیفی تحلیلی بود که بر روی 400 نفر از پرستاران شاغل در کلیه بیمارستان‌های آمو...
[ 17 ] - Anatomy in Reference Texts of Persian Medicine in Islamic Golden Age
Background and purpose: Anatomy is a branch of science that deals with different parts of human body and its organizational structure. It has various goals, such as insight into the divine perfection and understanding the causes of diseases and their treatments. Anatomy in the Islamic era included physiology too. This research aimed at providing an overview on anatomy in the Reference Materials...
[ 18 ] - Juglans Regia L. Leaf Extract Attenuates Diabetic Nephropathy Progression in Experimental Diabetes: An Immunohistochemical Study
Background: There is accumulating evidence that Juglans regia L. (GRL) leaf extract has hypoglycemic and antioxidative properties. The present study aimed to investigate the protective effects of GRL leaf extract against diabetic nephropathy (DN). Methods: In total, 28 male adult Sprague-Dawley rats were used. The DN rat model was generated by intraperitoneal injection of a single 55 mg/kg dose...
[ 19 ] - Anti-inflammatory and anti-apoptotic effects of hyperbaric oxygen preconditioning in a rat model of cisplatin-induced peripheral neuropathy
Objective(s): Cisplatin-induced peripheral neuropathy is a debilitating side effect in patients receiving this drug. Recent studies suggest hyperbaric oxygen (HBO) therapy as a new treatment approach for models of neural injury. The aim of the current study was to determine the protective effects of HBO preconditioning against peripheral neuropathy induced by Cisplati...
[ 20 ] - Synergistic Effect of Hyperbaric Oxygen and Decellularized Human Amniotic Membrane on Full-Thickness Diabetic Wound Healing in Rats
Background and purpose: One of the common complications of diabetes is impairment of wound healing. The aim of the present study was to investigate the synergistic effect of hyperbaric oxygen (HBO) therapy and decellularized human amniotic membrane (dHAM) in healing of full-thickness diabetic wounds in rats. Materials and methods: In this experimental study, 60 diabetic male rats were randoml...
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