Azam Mesdaghinia

[ 1 ] - Quetiapine reverse paclitaxel-induced neuropathic pain in mice: Role of Alpha2- adrenergic receptors

Objective(s): Paclitaxel-induced peripheral neuropathy is a common adverse effect of cancer chemo -therapy. This neuropathy has a profound impact on quality of life and patient’s survival. Preventing and treating paclitaxel-induced peripheral neuropathy is a major concern. First- and second-generation antipsychotics have shown analgesic effects both in humans and animals. Quetiapine is a novel ...

[ 2 ] - Antinociceptive effects of maprotiline in a rat model of peripheral neuropathic pain: possible involvement of opioid system

Objective(s): Neuropathic pain remains a clinical problem and is poorly relieved by conventional analgesics. This study was designed to determine whether maprotiline administration was effective in alleviating symptoms of neuropathic pain and whether the antinociceptive effect of maprotiline mediated through the opioid system. Materials and Methods: Neuropathic pain was induced by chronic cons...

[ 3 ] - The anti-inflammatory effects of venlafaxine in the rat model of carrageenan-induced paw edema

Objective(s):Recently anti-inflammatory effects of antidepressants have been demonstrated. Venlafaxine belongs to newer antidepressants with serotonin norepinephrine reuptake inhibition property. The pain alleviating properties of venlafaxine in different pain models such as neurogenic pain, diabetic neuropathy, and fibromyalgia have been demonstrated. Anti-inflammatory effects of venlafaxine a...

[ 4 ] - Gabapentin enhances anti-nociceptive effects of morphine on heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain

Objective(s):Neuropathic pain is caused by lesions or diseases affecting the somatosensory system and often responds poorly to typical medications. In this study, we evaluated anti-nociceptive effects of morphine, gabapentin and their combination on heat hyperalgesia, cold and mechanical allodynia in chronic constriction injury (CCI) model of neuropathic pain in rats. Materials and Methods: Mo...

[ 5 ] - Venlafaxine Attenuates Heat Hyperalgesia Independent of Adenosine or Opioid System in a Rat Model of Peripheral Neuropathy

Primarily opioidergic and adenosine mechanisms are considered to be involved in the antinociceptive effects of antidepressants. This study was designed to determine the efficacy of acute venlafaxine administration in alleviating symptoms of neuropathic pain and the role of endogenous adenosine and opioid systems in this effect of venlafaxine. We have evaluated the effect of caffeine, a non-sele...

[ 6 ] - Venlafaxine Attenuates Heat Hyperalgesia Independent of Adenosine or Opioid System in a Rat Model of Peripheral Neuropathy

Primarily opioidergic and adenosine mechanisms are considered to be involved in the antinociceptive effects of antidepressants. This study was designed to determine the efficacy of acute venlafaxine administration in alleviating symptoms of neuropathic pain and the role of endogenous adenosine and opioid systems in this effect of venlafaxine. We have evaluated the effect of caffeine, a non-sele...

[ 7 ] - اثر مهار آنزیم سیکلو اکسیژناز-2 بر آستانه تشنج ناشی از پنتیلن تترازول در موش سوری

سابقه و هدف: مطالعات قبلی نقش حفاظتی آنزیم سیکلواکسیژناز را در پیشرفت صرع نشان داده اند. بااین حال، دخالت سیکلواکسیژناز-2 در بیماریزایی صرع کاملا شناخته شده نیست. مطالعه حاضر با هدف بررسی اثر سلکوسیب و نیمزولاید (مهارکننده های اختصاصی سیکلو اکسیژناز-2) بر آستانه تشنج کلونیک ناشی از پنتیلن تترازول در موش های سوری طراحی گردید. مواد و روش ها: در این مطالعه تجربی موش های سوری نر سفید به صور...

[ 8 ] - بررسی الگوی مصرف و علل گرایش به اعتیاد در زنان تحت درمان نگهدارنده با متادون شهرستان کاشان طی سال 1396

سابقه و هدف: نرخ شیوع کنونی، نشان دهنده شیوع فزاینده سوء مصرف مواد در بین زنان است. مطالعه حاضر با هدف تعیین الگوی مصرف و علل گرایش به مصرف مواد مخدر در زنان مراجعه کننده به مراکز ترک اعتیاد می باشد. مواد و روش ها: مطالعه توصیفی– مقطعی حاضر روی کلیه زنان مراجعه کننده به مراکز ترک اعتیاد شهرستان کاشان طی سال 1396 انجام شد. ابزار پژوهش پرسشنامه اطلاعات دموگرافیک، علل گرایش به مصرف مواد مخدر و...