Fatemeh Safari
Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
[ 1 ] - Curcumin enhances liver SIRT3 expression in the rat model of cirrhosis
Objective(s): Bill duct ligation (BDL) is a representative model of biliary cholestasis in animals. Curcumin has a protective effect on the liver; however, its underlying mechanisms are not completely known. This study explored the hepatoprotective activity of curcumin on hepatic damage via measuring the expression of sirtuin3 (SIRT3), AMP-activated protein kinase (AMPK), carnitine palmitoyltra...
[ 2 ] - بررسی میزان شیوع و مقاومت آنتی بیوتیکی لیستریا مونوسیتوژنز درمراحل مختلف کشتار مرغ و محیط کشتارگاه مرغ شهرستان یزد در سال ۱۳۹۴
Introduction: Listeria monocytogenes is an important psychrotrophic foodborne pathogen that exists in poultry meat and causes listeriosis with severe clinical consequences such as meningitis, septicemia, and abortion. Therefore, contamination of food stuff implies a significant health risk for human. Data on contamination of poultry meat and poultry slaughterhouse with Listeria monocytoge...
[ 3 ] - The Effect of Nonpolar Fraction of Carum Copticum Essence on Acetylcholine Induced Contraction in the Ileum of Isolated Rats
Background and Aims: Our previous study has demonstrated that essence of Carum copticum reduces contraction activity of ileum in rat. The present study was designed to find out the effects of nonpolar fraction of Carum copticum essence (NFCCE) on mechanical activity of the isolated ileum in rat. Materials and Methods: For evaluation of spasmolythic property of fraction, different doses of the ...
[ 4 ] - اثر هم‌افزایی داروی مسدودکننده کلسیم (وراپامیل) و اسانس مرزه (Satureja hortensis L.) بر جلوگیری از انقباض کولینرژیک در ایلئوم موش سفید بزرگ آزمایشگاهی
وراپامیل با مهار کانال‌های کلسیمی نوع T فعال و غیرفعال از ورود کلسیم به داخل سلول‌ها جلوگیری میکند. با توجه به اینکه اثرات ضداسپاسمی مواد از طریق مهار کانال‌های کلسیمی اعمال می‌شود و اثر ضدانقباضی و کاهش فعالیت مکانیکی عضلات صاف ایلئوم توسط اسانس مرزه نشان داده شده‌است، مطالعه حاضر اثر هم‌افزایی کلسیم بلوکر وراپامیل و اسانس مرزه (Satureja hortensis L.) را بر جلوگیری از تحریک کولینرژیک ایلئوم ...
[ 5 ] - Therapeutic effects of 1,25-dihydroxyvitamin D and losartan co-administration on myocardial ischemia-reperfusion injury in rats
Introduction: Studies support the idea that low levels of vitamin D are associated with a higher risk of heart disease. Losartan has also been prescribed as a drug commonly used for treating hypertension. The aim of the current study was to investigate the effects of 1,25-dihydroxyvitamin D in combination with a non-hypotensive dose of losartan on myocardial infarct size, reperfusion-induced...
[ 6 ] - Effect of losartan on NOX2 transcription following acute myocardial ischemia-reperfusion
Introduction: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-2 (Nox2) is one of the predominant sources of ROS production during myocardial ischemia-reperfusion and can be induced by angiotensin II. The evidence suggests that pharmacological blockers of renin-angiotensin system can exert direct tissue effects independent of their ability to regulate blood pressure. The mechanism...
[ 7 ] - Acute effect of burn trauma to small skin areas on myocardial ischemia reperfusion
Introduction: It has been reported that traumas such as transverse abdominal incision before myocardial ischemia result in a significantly decreased infarct size. This phenomenon is named remote preconditioning of trauma. Since small skin burn is one of most common traumas, the effect of this injury on ischemia-induced arrhythmias and infarct size was investigated in a rat model of ischemia-...
[ 8 ] - Effects of pretreatment with non hypotensive dose of ramiprilat and losartan on myocardial ischemia-reperfusion induced arrhythmias and infarct size in rats
Introduction: Inhibition of renin angiotensin system represents an important approach in the management of cardiovascular diseases. The aim of this study was to explore the effects of pretreatment with non-hypotensive dose of angiotensin converting enzyme (ACE) inhibitor, ramiprilat and angiotensin type 1 (AT1) receptor blocker, losartan on myocardial infarct size and arrhythmias in a rat mo...
[ 9 ] - Resveratrol Suppresses Cardiac Renin Angiotensin System in the Late Phase of Left Ventricular Hypertrophy
Background and objectives: Resveratrol(3,5,4′-trihydroxy-trans-stilbene) is a natural polyphenole phytoalexin which exerts potential cardioprotective effects, but the cellular and molecular mechanisms responsible for these effects are still unknown. Cardiac renin angiotensin system (RAS) over-activation plays an important role in pathogenesis of left ventricula...
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