Mohammad Allahtavakoli
Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran|Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
[ 1 ] - Protective effect of metformin on D-galactose-induced aging model in mice
Objective(s): Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. Materials and Methods: Met (1 and 10 mg/kg/p.o.), ...
[ 2 ] - Effects of Low-dose Morphine on Nitric Oxide Concentration and Angiogenesis in Two-kidney One Clip Hypertensive Rats
Objective(s) We investigated the effects of low-dose morphine on nitric oxide (NO) and angiogenesis in two-kidney one clip hypertensive (2K1C) rats. Materials and Methods Male rats were divided into two groups: sham-clip operated and 2K1C. Each group subdivided into saline and morphine (3 mg/kg i.p. 8 weeks) groups. Blood pressure, heart rate, plasma renin activity (PRA), NO concentration an...
[ 3 ] - Effect of Morphine Withdrawal Syndrome on Cerebral Ischemia Outcome in Rats
Objective(s) Opioid abuse is still remained a major mental health problem, a criminal legal issue and may cause ischemic brain changes including stroke and brain edema. In the present study, we investigated whether spontaneously withdrawal syndrome might affect stroke outcomes. Materials and Methods Addiction was induced by progressive incremental doses of morphine over 7 days. Behavioral si...
[ 4 ] - Vitamin E Derivative Alpha-Tocotrienol Failed to Show Neuroprotective Effects after Embolic Stroke in Rats
Objective(s) Previous studies have demonstrated that pretreatment with alpha-tocotrienol (a-TCT) can reduce ischemic damage in mice following middle cerebral artery (MCA) occlusion. It is also reported to decrease stroke- dependent brain tissue damage in 12-Lox-deficient mice and spontaneously hypertensive rats. In the present study, the neuroprotective effects of a-TCT and rosiglitazone (RGZ)...
[ 5 ] - اثر محافظتی درمان ترکیبی با هیپوترمی موضعی مغز و کرانیکتومی بر مدل سکته مغزی
Background and purpose: Both hypothermia and Decompressive craniectomy (DC) have been shown to reduce ischemic injury in experimental middle cerebral artery occlusion (MCAO). This study was designed to evaluate the effect of delayed combination of DC and Local Hypothermia (LH) on infarct size, neurological outcome and blood brain barrier (BBB) disruption in a rat model of stroke. Material a...
[ 6 ] - اثر عصاره هیدروالکلی درمنه کوهی بر روند بهبود زخم پوستی در موش صحرایی
Background and purpose: Ârtemisia aucheri (Âra) is a plant with evident anti-inflammatory and anti-microbial properties. Ïn the present study, we investigate the effect of hydro-alcoholic extract of Âra on skin wound healing among male rats. Materials and methods: 30 male Wistar rats were randomly divided into 3 equal groups: control group receiving saline as wound treatment and two study ...
[ 7 ] - مقایسه اثر عصاره آبی خاکشیر بر اسهال ایجاد شده با روغن کرچک در موش صحرایی نر
Background and Objectives: Diarrhea is one of the worldwide health problems and one of the most common causes of childrens’ mortality. In the present experiment, effect of Descurainia sophia on castor oil-induced diarrhea was investigated. Materials and Methods: In this experimentd study 24 male rats were randomly divided into 4 groups as follows: Descurainia sophia with doses of 400 and 60...
[ 8 ] - اثر پیش شرطی‌سازی با ورزش بر پیامدهای سکتۀ مغزی در یک مدل موشی آزمایشگاهی
مقدمه: سکتۀ مغزی یکی از علل عمدۀ مرگ و میر و ناتوانی‌های طولانی مدت در بزرگسالان است. خطر بروز سکتۀ مغزی در زنان در سنین پس از یائسگی به‌سرعت در حال افزایش است. گزارش شده است که ورزش آسیب ناشی از ایسکمی و رپرفیوژن را در مدل سکتۀ مغزی موش صحرایی کاهش می‌دهد. هدف از این مطالعه بررسی اثر ورزش بر روی پیامدهای سکتۀ مغزی در انسداد دایم شریان مغزی میانی در موش‌های اوارکتومی شده بود. مواد و روش‌ها: 32 ...
[ 9 ] - Effect of Teucrium polium extract on skin wound healing in rat
Introduction: Teucrium polium (TP) is a plant which its anti-inflammatory and antimicrobial properties has been widely reported. In the present experiment, effect of hydroalcoholic extract of TP on skin wound healing in rats is investigated. Methods: 30 wistar rats randomly divided in 3 equal groups as follow: control (saline), 50 and 100 mg/ml of TP extract. One day after wounds inductio...
[ 10 ] - Investigate the effect of TRPV1 receptor antagonist (AMG9810) on stroke outcome in the permanent middle cerebral artery occlusion in male rat
Introduction: TRPV1 is a non-selective cation channel with high permeability to calcium ions, and is also involved in the development of neurogenic and inflammatory pain. The increase in intracellular calcium plays a role in worsening of stroke. In the present study we investigated the effect of (AMG9810) TRPV1 receptor antagonist on stroke outcome in the permanent middle cerebral artery occlus...
[ 11 ] - اثر عصاره هیدروالکلی گیاه گارچی بر زخم پوستی و مقایسه آن با پماد فنی توئین
Background & Objectives: Ferulago angulata is one of the most important herbs used in the traditional medicine for the treatment of skin wounds in the region of Golbaf located in Kerman, Iran. This study aimed to compare the effects of ferulago angulata hydro-alcoholic extract and 1% phenytoin cream on skin ulcers. Materials & Methods: In this experimental study, 20 male mice were divided...
[ 12 ] - بررسی اثر عصاره آبی- الکلی گیاه درمنه (Artemisia Aucheri) بر سمیت کلیوی ناشی از کلرید جیوه دو ظرفیتی در موش سفید کوچک آزمایشگاهی
زمینه و هدف: فلزات سنگین از طریق افزایش تولید رادیکال‌های آزاد اکسیژن در بافت کلیه سبب سمیت کلیوی در انسان و حیوانات می‌شوند. ترکیبات آنتی‌اکسیدانی موجود در گیاهان دارویی گزینه‌های مناسبی برای حفاظت در برابر مسمومیت ناشی از این مواد هستند. در تحقیق حاضر برای اولین بار اثر حفاظتی عصاره آبی الکلی گیاه درمنه بر سمیت کلیوی ناشی از کلرید جیوه ارزیابی گردید. روش بررسی: در این تحقیق از 28 سر موش سوری...
[ 13 ] - تأثیر تروگزروتین بر سطح سرمی گلوکز و فعالیت لاکتات دهیدروژناز متعاقب شنا وامانده ساز در موش های صحرایی نر
زمینه و هدف: ورزش وامانده ساز منجر به آسیب عضلانی و کاهش منابع انرژی نظیر گلوکز می‌شود. هدف مطالعه حاضر بررسی اثر مکمل تروگزروتین بر سطح سرمی گلوکز و فعالیت لاکتات دهیدروژناز متعاقب شنا وامانده ساز در موش‌های صحرایی نر بود. روش بررسی: در این مطالعه تجربی، 32 سر موش صحرایی نر نژاد ویستار به صورت تصادفی به 4 گروه کنترل، ورزش + 75 میلی گرم بر کیلوگرم، ورزش+ 150 میلی گرم بر کیلوگرم و ورزش + 300 میل...
[ 14 ] - مطالعه اثر عصاره هیدروالکلی خاکشیر، درمنه و کلپوره بر سندرم ترک مورفین القا شده با نالوکسان در موش صحرایی نر
زمینه و هدف: سندرم ترک یکی از عوارض خطرناک و بحرانی سوء استفاده از مواد مخدر است و درمان آن از اولویت‌‌‌‌‌‌‌‌‌های بهداشتی و درمانی محسوب می شود. هدف این مطالعه بررسی اثر عصاره خاکشیر، درمنه و کلپوره بر علائم ناشی از سندرم ترک مورفین می باشد. روش بررسی: در این مطالعه تجربی، 40 سر موش صحرایی نر به چهار گروه مساوی شامل: گروه کنترل که مورفین، نالوکسان و آب مقطر دریافت کردند، گروه وابسته به مورفین...
[ 15 ] - بررسی اثرات عصاره متانولی دانه گیاه رازیانه در مدل پارکینسونی ایجادشده توسط تزریق داخل بطنی 6-هیدروکسی دوپامین در موش‌های صحرایی ماده، با استفاده از آزمون‌های رفتاری
Background and Aim: Oxidative stresses are involved in neuronal degeneration of substantia nigra and thereby induction of Parkinson's disease. It is reported that Foeniculum Vulgare L. can affect lactating and modulating dopaminergic system activity and antioxidant activity as well. In the present study, the effects of methanolic extract of Foeniculum Vulgare seeds on a Parkinson’s disease mode...
[ 16 ] - بررسی اثر متفورمین بر روی برخی شاخص‌های رفتاری در موش سوری اوارکتومی شده
Introduction: Aging process is inevitable, which increases the risk of illness and death in people. Menopause occurs as a part of the aging process. The aim of this study was to evaluate the effect of metformin (Met) on muscle strength, anxiety and memory in ovariectomized mice Methods: Thiswas an experimental study. 96 female mice (Age 6 months) (20-25 g) were randomly divided into sex group...
[ 17 ] - The effects of single dose administration of opium on muscular and central fatigue in male rats
Introduction: Exhaustive exercise leads to muscle fatigue and reduces muscle power in response to contractile activity and causes central fatigue. On the other hand, the effects of opioids on skeletal muscles and fatigue phenomenon are not known completely. Thus, the current study aimed to assess the effect of a single dose administration of opium on muscle and central fatigue in male rats. ...
[ 18 ] - Effect of Hypothermia by JZL-184 on Muscle Strength and Sensory-Motor Dysfunction in Permanent Middle Cerebral Artery Ischemia Model in Male Mice
Introduction: Currently, there is no effective and comprehensive treatment for ischemic stroke. There is strong clinical evidence for the benefits of hypothermia in neuroprotection. Therefore, the present study aimed to determine the effect of mild non-invasive hypothermia by JZL-184 on behavioral improvement in stroke rats. Methods: This study was performed on 5 groups of male mice weighing 2...
[ 19 ] - Effect of Troxerotin on permanent cerebral ischemia in male mice
Introduction: Stroke is a neurological disease and one of the leading causes of death all over the world. It is also an important cause of disability in people over age over 65. It may be possible to reduce the incidence of cerebral ischemia using antioxidants, followed by inhibition of oxidative and inflammatory mechanisms. Troxerutin is a natural bioflavonoid with antioxidant and anti-inflamm...
[ 20 ] - Effect of Metformin on Some Cognitive Functions in Old Rats
Introduction: Aging is a complex process and is considered as a risk factor for many diseases such as hypertension, Alzheimer, cancer, depression and anxiety. Recently, it has been shown that metformin, an anti-diabetic drug, has important neurological effects such as preventing memory loss, stroke, anxiety, inflammation and seizures. Therefore, the aim of this study was investigating the effec...
[ 21 ] - Pretreatment effects of metformin on behavioral manifestations of global ischemia/reperfusion injury in rats
Introduction: Metformin (MET) as an oral antidiabetic drug has pleiotropic effects such as antioxidative and neuroprotective properties. In the current study we aimed to investigate the probable effects of Pretreatment MET therapy in global ischemia-reperfusion in rats. Materials and Methods: In this study, 40 male Wistar rats (200-220 g) were used. Animals were randomly divided into four g...
[ 22 ] - Effect of Ischemic Conditioning on Some Motor and Cognitive Factors in the Ovariectomy-Induced Aged Rats
Introduction: During menopause, which is a part of the aging process in women, the level of sex hormones decreases, which causes problems such as memory impairment and cognitive functions. One of the treatment options for these disorders is hormone therapy, which has several side effects. The present study investigated the effect of remote ischemic conditioning (RIC) technique on memory improve...
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