Azar Tahghighi
Malaria and Vector Research Group (MVRG), Biotechnology Research Center (BRC), Pasteur Institute of Iran, Tehran, Iran
[ 1 ] - Synthesis and antiplasmodial activity of novel phenanthroline derivatives: An in vivo study
Objective(s): Due to the rapid increased drug resistance to Plasmodium parasites, an urgent need to achieve new antiplasmodial drugs is felt. Therefore, in this study, the new synthetic phenanthroline derivatives were synthesized with antiplasmodial activity. Materials and Methods: A series of 1,10-phenanthroline derivatives containing amino-alcohol and amino-ether substituents were synthesized...
[ 2 ] - Thiadiazoles: the appropriate pharmacological scaffolds with leishmanicidal and antimalarial activities: a review
Leishmaniasis and malaria are serious public health problems in tropical and sub-tropical regions worldwide. Development of drug-resistant strains has disrupted efforts to control the spread of these diseases in the world. The conventional antiparasitic chemotherapy still suffers from side effects and drug resistance. Therefore, the development of novel antimalarial and leishmanicidal drugs rem...
[ 3 ] - بررسی مروری اهمیت حلقه کینولون در دستیابی به داروهای ضد مالاریای جدید
Malaria is an acute and chronic disease caused by obligate intracellular protozoan parasites of the genus plasmodium, transmitted through the bite of female anopheles mosquitoes. According to the World Health Organization (WHO) report, currently malaria transmits in 104 countries and due to a failure in the fight against this disease, their control and elimination is difficult. The parasite res...
[ 4 ] - Introducing New Antimalarial Analogues of Chloroquine and Amodiaquine: A Narrative Review
Antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (CQ) and amodiaquine (AQ), have been used to prevent and treat malaria for many years. The importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. In recent years, with the spread of parasite resistance to CQ and cross-resist...
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