Amin Hasanvand
2Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran|Department of Pharmacology and Toxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
[ 1 ] - Minocycline through attenuation of oxidative stress and inflammatory response reduces the neuropathic pain in a rat model of chronic constriction injury
Objective(s): Several lines of evidence showed that minocycline possesses antioxidant and anti-inflammatory properties. This study aimed to demonstrate the effects of minocycline in rats subjected to chronic constriction injury (CCI). Materials and Methods: In this study four groups (n = 6–8) of rats were used as follows: Sham, CCI, CCI + minocycline (MIN) 10 mg/Kg (IP) and CCI + MIN 30 mg/Kg (...
[ 2 ] - بررسی اثرات عصاره سیر، عصاره برگ گزنه و عصاره زیتون بر سطح سرمی فاکتورهای التهابی پروتئین التهابی C و اینترلوکین-6 و فاکتور نکروز توموری آلفا در رت های مبتلا به دیابت
Introduction: It has been demonstrated that the inflammatory markers such as IL-6, TNF-α and CRP are increased in STZ-diabetic rats. The present study is to investigate the effects of medicinal plants used in traditional medicine, including garlic extract; nettle leaves extract and olive extract on serum hsCRP and IL-6 and TNF-α on the rats with diabetes. Methods: Diabetes was indu...
[ 3 ] - بررسی اثرات ضد التهابی و آنتی‌اکسیداتیو فلوکستین در یک مدل تجربی درد نوروپاتی در موش سفید آزمایشگاهی
هدف: یکی از مهم‌ترین عوارض جانبی بعد از آسیب‌های عصبی، درد نوروپاتیک می‌باشد. افزایش سطح سیتوکین‌های التهابی و استرس اکسیداتیو نقش مهمی در ایجاد درد بازی می‌کنند. فلوکستین یکی از مهم‌ترین داروهای مورد استفاده در درمان افسردگی می‌باشد که نشان داده شده دارای اثرات ضد التهابی و آنتی‌اکسیداتیو می‌باشد. هدف این مطالعه، بررسی اثرات ضد التهابی و آنتی‌اکسیداتیو فلوکستین در مدل تجربی درد نوروپاتیک (Chro...
[ 4 ] - Neuroprotective and Anti-inflammatory Role of Atorvastatin and Its Interaction with Nitric Oxide (NO) in Chronic Constriction Injury-induced Neuropathic Pain
Prevention and treatment of neuropathic pain (NP) is one of the most difficult problemsin clinical practice since the underlying mechanism of NP is unclear. In previous studies, theincreased production of nitric oxide (NO) has been closely linked to the induced NP. In thisstudy, we assessed the effect of atorvastatin through NO mechanism, on inflammation, thermalhyperalg...
[ 5 ] - Neuroprotective and Anti-inflammatory Role of Atorvastatin and Its Interaction with Nitric Oxide (NO) in Chronic Constriction Injury-induced Neuropathic Pain
Prevention and treatment of neuropathic pain (NP) is one of the most difficult problemsin clinical practice since the underlying mechanism of NP is unclear. In previous studies, theincreased production of nitric oxide (NO) has been closely linked to the induced NP. In thisstudy, we assessed the effect of atorvastatin through NO mechanism, on inflammation, thermalhyperalg...