Shirin Babri
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
[ 1 ] - Effects of troxerutin on anxiety- and depressive-like behaviors induced by chronic mild stress in adult male rats
Objective(s):Chronic stress has been linked to the pathophysiology of mood disorders including anxiety and depression. In this study, we aimed to investigate the effect of troxerutin (TRX), as a flavonol, on stress-induced anxiety and depression.Materials and Methods: 56 animals were randomly divided into seven groups (n=8 per group) as follows: control, saline, TRX 50, TRX 150, TRX 300, Diazep...
[ 2 ] - Protective effects of troxerutin on maternal high-fat diet-induced impairments of spatial memory and apelin in the male offspring
Objective(s): Maternal high-fat diet (HFD) is linked with metabolic and cognitive deficits in offspring. Neuroprotective effects of troxerutin, a natural bioflavonoid, have been reported recently. This study aimed to investigate the effects of troxerutin on spatial memory and serum and hippocampal apelin levels in the male offspring of HFD fed mothers.Materials and Methods: Three-week-old femal...
[ 3 ] - بررسی اثرات پیراستام در اختلالات تثبیت حافظه ناشی از قرارگیری در معرض میدان مغناطیسی
زمینه وهدف: پیراستام از ترکیبات محرک مغزی است که عملکرد سیستم عصبی را تقویت می کند. تشکیل حافظه ترکیبی از روندهای مختلف است که عوامل متفاوتی قادر به اختلال در آن هستند. با توجه به افزایش احتمال قرارگیری در معرض میدانهای مغناطیسی در سالهای اخیر واثرات مطرح این میدانها برروندتثبیت حافظه مطالعه مذکور طرح ریزی گردید تا نقش این دو عامل در ارتباط با حافظه مشخص شود. روش کار : دراین مطالعه یازده گروه د...
[ 4 ] - اثر گرلین بر سطح گلوکز پلاسما، وزن بدن، مصرف غذا و هماتوکریت در هیپوکسی سیستمیک حاد و مزمن در موشهای صحرایی نر بالغ
مقدمه: هیپوکسی حاد و مزمن میزان قند خون را تحت تاثیر قرار میدهد و سبب کاهش وزن بدن میشود. گرلین سبب افزایش اشتها، افزایش وزن، تنظیم سوخت و ساز و نیز هومئوستاز گلوکز میشود. بنابراین، در پژوهش حاضر اثر تجویز حاد و مزمن گرلین بر سطح گلوکز خون، وزن بدن، مصرف غذا و هماتوکریت در مدل هیپوکسی سیستمیک حاد و مزمن در موشهای نر بالغ بررسی گردید. مواد و روشها:...
[ 5 ] - Effect of forced treadmill exercise on long-term potentiation (LTP) in the dentate gyrus of hippocampus in male rats
Introduction: Previous studies indicate that exercise influences cognitive function. Nevertheless, considering that exercise in animal study can be voluntary, or forced, effects of exercise (specially forced exercise) on learning and memory abides as a matter of controversy. The present study aimed to investigate the effects of treadmill exercise on LTP in the dentate gyrus of rats. Methods: T...
[ 6 ] - Effects of troxerutin on inflammatory cytokines and BDNF levels in male offspring of high-fat diet fed rats
Objective: In the present study, we aimed to examine the effect of troxerutin treatment on levels of brain-derived neurotrophic factor (BDNF), and tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), as pro-inflammatory cytokines, in the blood and hippocampus of high-fat diet (HFD) fed dams and their male offspring. <span ...
[ 7 ] - Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats
Objective(s): Maternal high-fat diet (HFD) consumption has been linked to metabolic disorders and reproductive dysfunctions in offspring. Troxerutin (TRO) has anti-hyperlipidemic, anti-oxidant, and anti-inflammatory effects. This study examined the effects of TRO on apelin-13, its receptors mRNA and ovarian histological changes in the offspring of HFD fed rats. <...
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