Fatemeh Kazemi-Lomedasht
Biotechnology Research Center, Venom & Biotherapeutics Molecules Lab, Pasteur Institute of Iran, Tehran, Iran
[ 1 ] - Cell-specific targeting by engineered M13 bacteriophage expressing VEGFR2 nanobody
Objective(s): Filamentous bacteriophage M13 was genetically engineered to specifically target mammalian cells for gene delivery purpose. Materials and Methods: A vascular endothelial growth factor receptor 2 (VEGFR2)-specific nanobody was genetically fused to the capsid gene III of M13 bacteriophage (pHEN4/3VGR19). A mammalian expression construct containing Cop-green fluorescent protein (Cop-G...
[ 2 ] - Serologic Survey of Crimean-Congo Haemorrhagic Fever among Sheep in Ardabil Province, Northwest Iran
Introduction: Livestock is a known source of Crimean-Congo Hemorrhagic Fever (CCHF) virus infection in humans. Although CCHF is endemic in Iran, limited human cases of CCHF are reported from northwest of Iran. Considering the lack of complete and updated information on the status and distribution of CCHF infection among domestic animals in Ardabil province, this study was conducted to investiga...
[ 3 ] - In vitro combination therapy of pathologic angiogenesis using anti-vascular endothelial growth factor and anti-neuropilin-1 nanobodies
Objective(s): Emergence of resistant tumor cells to the current therapeutics is the main hindrance in cancer treatment. Combination therapy, which mixes two or more drugs, is a way to overcome resistant problems of cancer cells to current treatments. Nanobodies are promising tools in cancer therapy due to their high affinity as well as high penetration to tumor sites....