Mustafa Ghanadian
Assistant Professor, Pharmacognosy Department, Isfahan Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
[ 1 ] - Nutraceuticals in Hyperlipidemic Children: a Systematic Review and Meta-analysis
Background Dyslipidemia is a major risk for cardiovascular diseases. The aim of this study is to review the effects of nutraceuticals to modify lipid disorders in children. Materials and Methods The literature research was conducted in EMBASE, Medline, PubMed, Scopus, ISI Web of Science, and Cochrane library from 2002 until January 2015. The following keywords were used: dyslipidemia, hyperlipi...
[ 2 ] - A New Taraxastane Triterpene from Euphorbia Denticulata with Cytotoxic Activity Against Prostate Cancer Cells
In this research, aerial parts of Euphorbia denticulata Lam were collected from Sanandaj city in Kurdistan province at the West of Iran. It was extracted by maceration using acetone as solvent. Isolation of compounds were carried out with repeated column chromatography using silica gel and normal preparative HPLC using YMC-Pack-Sil column and hexane: ethyl acetate as mobile phase. The structure...
[ 3 ] - Isolation and identification of secondary metabolites from the aerial parts of Stachys lavandulifolia Vahl
Stachys lavandulifolia Vahl is an herbaceous wild plant native to Iran which is traditionally used in Iranian folk medicine as a mild sedative tea for reducing anxiety and for treatment of gastrointestinal disorders. Our previous study on ethyl acetate extract of S. lavandulifolia proved anti-anxiolytic activity and so the present study was designed to determine chemical components of this biol...
[ 4 ] - Triterpene Constituents of Euphorbia Erythradenia Bioss. and their Anti-HIV Activity
Phytochemical investigation of the aerial parts of Euphorbia erythradenia Bioss. (Euphorbiaceae), one of Iranian endemic Euphorbias, with particular attention to triterpene constituents, using methanol solvent extraction was carried out. Five known triterpenes, including four cycloartanes and oleanolic acid, were isolated for the first time and identified using NMR and Mass techniques. Anti HIV...
[ 5 ] - Isolation and Identification of a New Phenylpropanoid Derivative from the Fruits of Pimpinella Haussknechtii Rech. f. & Riedl and GC-MS Analysis of the Essential Oil
The chemical composition of the essential oil of fruits of Pimpinella haussknechtiiBoiss.was studied by GC-MS. After GC-MS analysis, one unknown component (56.7%) was observed, which was not characterized in the GC-MS library. The essential oil of P.hauskenekhtii was injected to HPLC using YMC-Pak-Sil column (250 × 20 mm) with gradient system of hexane (A), and hexane: ethyl acetate, 9:1 (B) to...
[ 6 ] - Methoxylated Flavones from Salvia Mirzayanii Rech. f. and Esfand with Immunosuppressive Properties
Aerial parts of Salvia Mirzayanii was extracted with methanol. Methanol extract was suspended in water and defatted with petroleum ether. The defatted part was then partitioned between ethyl acetate and water. The ethyl acetate partition was chromatographed on a silica gel column to afford several fractions. Lymphocyte proliferation inhibitory assay of the resulted fractions was compared in vit...
[ 7 ] - Triterpenes and steroids from Euphorbia denticulate Lam. with Anti-Herpes Symplex virus activity
In this research, dried acetone:chloroform extract of aerial parts of E. denticulata as one of the endemic plants to Iran, afforded a number of triterpenes and steroids including: betulin, 24-methylene-cycloart-3-ol, cycloart-23Z-ene-3β,25-diol, cycloart-23Z-ene-3β,25-diol, ergosta-8,24-dien-3-ol (obtusifoliol) and beta-sitosterol which were reported for the first time from this plant. The stru...
[ 8 ] - Flavonol Glycosides from Euphorbia microsciadia Bioss. with their Immunomodulatory Activities
Four known flavonoids: quercetin 3-O-β-D-rutinoside (Q3Rut), myricetin 3-O-β-D-galactopyranoside (M3Gal), quercetin 3-O-β-D-galactopyranoside (Q3Gal) and quercetin 3-O-β-D-glucopyranoside (Q3Glc), for the first time were isolated from aerial parts of Euphorbia microsciadia. The chemical structure of them was elucidated on the basis of 1 and 2 D-NMR spectra and different spectroscopic techniques...
[ 9 ] - Biotic elicitation for scopolamine production by hairy root cultures of Datura metel
The (-)-hyoscyamine, atropine and scopolamine (hyoscine) are three valuable tropane alkaloids while scopolamine is the most important member of this group for the pharmaceutical industry due to its higher demand compared to hyoscyamine and atropine. Scopolamine is an anticholinergic reagent with several therapeutic applications. In the current study, the hairy roots culture of Daturametel was u...
[ 10 ] - A New Taraxastane Triterpene from Euphorbia Denticulata with Cytotoxic Activity Against Prostate Cancer Cells
In this research, aerial parts of Euphorbia denticulata Lam were collected from Sanandaj city in Kurdistan province at the West of Iran. It was extracted by maceration using acetone as solvent. Isolation of compounds were carried out with repeated column chromatography using silica gel and normal preparative HPLC using YMC-Pack-Sil column and hexane: ethyl acetate as mobile phase. The structure...
[ 11 ] - Isolation and identification of secondary metabolites from the aerial parts of Stachys lavandulifolia Vahl
Stachys lavandulifolia Vahl is an herbaceous wild plant native to Iran which is traditionally used in Iranian folk medicine as a mild sedative tea for reducing anxiety and for treatment of gastrointestinal disorders. Our previous study on ethyl acetate extract of S. lavandulifolia proved anti-anxiolytic activity and so the present study was designed to determine chemical components of this biol...
[ 12 ] - Triterpene Constituents of Euphorbia Erythradenia Bioss. and their Anti-HIV Activity
Phytochemical investigation of the aerial parts of Euphorbia erythradenia Bioss. (Euphorbiaceae), one of Iranian endemic Euphorbias, with particular attention to triterpene constituents, using methanol solvent extraction was carried out. Five known triterpenes, including four cycloartanes and oleanolic acid, were isolated for the first time and identified using NMR and Mass techniques. Anti HIV...
[ 13 ] - Isolation and Identification of a New Phenylpropanoid Derivative from the Fruits of Pimpinella Haussknechtii Rech. f. & Riedl and GC-MS Analysis of the Essential Oil
The chemical composition of the essential oil of fruits of Pimpinella haussknechtiiBoiss.was studied by GC-MS. After GC-MS analysis, one unknown component (56.7%) was observed, which was not characterized in the GC-MS library. The essential oil of P.hauskenekhtii was injected to HPLC using YMC-Pak-Sil column (250 × 20 mm) with gradient system of hexane (A), and hexane: ethyl acetate, 9:1 (B) to...
[ 14 ] - Methoxylated Flavones from Salvia Mirzayanii Rech. f. and Esfand with Immunosuppressive Properties
Aerial parts of Salvia Mirzayanii was extracted with methanol. Methanol extract was suspended in water and defatted with petroleum ether. The defatted part was then partitioned between ethyl acetate and water. The ethyl acetate partition was chromatographed on a silica gel column to afford several fractions. Lymphocyte proliferation inhibitory assay of the resulted fractions was compared in vit...
[ 15 ] - Triterpenes and steroids from Euphorbia denticulate Lam. with Anti-Herpes Symplex virus activity
In this research, dried acetone:chloroform extract of aerial parts of E. denticulata as one of the endemic plants to Iran, afforded a number of triterpenes and steroids including: betulin, 24-methylene-cycloart-3-ol, cycloart-23Z-ene-3β,25-diol, cycloart-23Z-ene-3β,25-diol, ergosta-8,24-dien-3-ol (obtusifoliol) and beta-sitosterol which were reported for the first time from this plant. The stru...
[ 16 ] - Flavonol Glycosides from Euphorbia microsciadia Bioss. with their Immunomodulatory Activities
Four known flavonoids: quercetin 3-O-β-D-rutinoside (Q3Rut), myricetin 3-O-β-D-galactopyranoside (M3Gal), quercetin 3-O-β-D-galactopyranoside (Q3Gal) and quercetin 3-O-β-D-glucopyranoside (Q3Glc), for the first time were isolated from aerial parts of Euphorbia microsciadia. The chemical structure of them was elucidated on the basis of 1 and 2 D-NMR spectra and different spectroscopic techniques...
[ 17 ] - Standardized Punica Granatum Pericarp Extract, Suppresses Tumor Proliferation and Angiogenesis in a Mouse Model of Melanoma: Possible Involvement of PPARα and PPARγ Pathways
Melanoma is a challenging disease to treat. Punica granatum L. has a potential anticancer effect. This study determined the antiproliferative and antiangiogenic potential of the extract from pomegranate peel (PPE) in melanoma. Melanoma cells (1 × 106) were injected to C57BL6 mice subcutaneously. On 8th day, mice were randomly divided into 9 groups. Group 1 was considered as control and received...
[ 18 ] - Standardized Punica Granatum Pericarp Extract, Suppresses Tumor Proliferation and Angiogenesis in a Mouse Model of Melanoma: Possible Involvement of PPARα and PPARγ Pathways
Melanoma is a challenging disease to treat. Punica granatum L. has a potential anticancer effect. This study determined the antiproliferative and antiangiogenic potential of the extract from pomegranate peel (PPE) in melanoma. Melanoma cells (1 × 106) were injected to C57BL6 mice subcutaneously. On 8th day, mice were randomly divided into 9 groups. Group 1 was considered as control and received...
[ 19 ] - مقایسه اثر عصاره الکلی و فراکسیون های زعفران با کلروکین روی پلاسمودیوم برگئی در موش سوری در شرایط in vivo
Background and Aim: Medicinal plants provide an excellent source of drugs and new drug combinations, including the basis for the development of drug resistance to common anti-malarial treatments. In this study we investigated and compared the effect of an alcoholic extract of saffron and its constituents with that of chloroquine on malaria in mice. Materials and Methods: A total of 65 male m...
[ 20 ] - بررسی اثرات ترکیب اسپیناستین-7-O- بتا گلوکوزید بر مهار رشد و القای آپوپتوز در رده سلولی MCF-7 سرطان پستان
زمینه و هدف: این مطالعه بهمنظور بررسی تأثیر اسپیناستین گلیکوزاید ترکیب فلاونوئیدی جداشده از گیاه Centurea shmidi بر مهار رشد و القای آپوپتوز در رده سلولی MCF-7 سرطان پستان انجام شد. روش بررسی: در این مطالعه میزان مهار رشد سلولی و القای آپوپتوز در سلولهای حاصل از کشت ردههای سلولی MCF-7 پس از تیمار با غلظتهای مختلف اسپیناستین گلیکوزاید بهوسیلهی روشهای MTT و فلوسایتومتری مورد بررسی قرار گرف...
[ 21 ] - Effects of CuSO4 and AgNO3 on artemisinin and phenolic compound in shoot cultures of Artemisia annua L.
In the present study, the effect of exogenous silver nitrate (Ag+) and copper sulfate (Cu2+) applications on production of artemisinin and phenolic compounds as well as oxidative stress in the shoot cultures of Artemisia annua was investigated. A significant decrease in the shoot biomass and the total chlorophyll was observed in the shoots exposed to increased Ag concentration. Additionally, a ...
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