Abbas Mirshafiey
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
[ 1 ] - Immunomodulation of TLR2 and TLR4 by G2013 (alfa-L-Guluronic acid) in CVID Patients
Background: Common variable immunodeficiency (CVID) is a primary immune disorder associated with hypogammaglobulinemia, recurrent infections and autoimmune diseases. CVID patients are frequently in contact with infectious pathogens leading to the activation of innate immunity through Toll-like receptors (TLR) affecting adaptive immunity. The aim of the present study was to test the immunomedula...
[ 2 ] - Vitamin D3 Induces Gene Expression of Ox-LDL Scavenger Receptors in Streptozotocin-Induced Diabetic Rat Aortas: New Insight into the Role of Vitamin D in Diabetic Atherosclerosis
Background: Several lines of evidence suggest that oxidized LDL (Ox-LDL) scavenger receptors play a crucial role in the genesis and progression of diabetic atherosclerosis. This study aimed to elucidate the effect of vitamin D3 on gene expression of lectin-like oxidized LDL receptor-1 (LOX-1), scavenger receptor-A (SR-A), Cluster of Differentiation 36 (CD36), and Cluster of Differentiation 68 (...
[ 3 ] - Vitamin D suppresses cellular pathways of diabetes complication in liver
Objective(s): The aim of this study was to investigate the effect of vitamin D on glucose metabolism, as well as the expression of five key genes involved in the development of diabetes complications in liver tissue of diabetic rats. Materials and Methods: Twenty-four male Sprague–Dawley rats were randomly divided into three groups (8 ra...
[ 4 ] - تاثیر تمرینات مقاومتی بر سطوح آدیپولین سرم و شاخص مقاومت به انسولین در زنانِ چاق
آدیپولین (CTRP12) آدیپوکاینی است نوظهور با خاصیت ضدالتهابی که عمدتاً در بافت چربی بیان و سنتز میشود. آدیپولین ضمن بهبود حساسیت به انسولین، در کاهش سطح گلوکز خون نیز نقش دارد. پژوهش حاضر تاثیر تمرینات مقاومتی بر سطوح آدیپولین و شاخص مقاومت به انسولین (HOMA-IR) را در زنان چاق مورد بررسی قرار داده است. بدین منظور 20 زن چاقِ یائسه و غیرفعال (شاخص تودۀ بدنی> 30 کیلوگرم بر مترمربع، 65-50 سا...
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