Voltammetric Investigation of Thioridazine Using a Carbon Nanocomposite Electrode in Human Biological Samples

An electrochemical method employing a carbon nanocomposite electrode was developed to measure thioridazine. The electrode has been designed by incorporation of montmorillonite nanoclay into the carbon ionic liquid electrode. Surface morphology of the electrodes was done using scanning electron microscopy. Adsorptive stripping voltammetry was applied as a very sensitive analytical method for the determination of sub-micromolar amounts of thioridazine. The optimized linear working range and detection limit (S/N=3) are 0.1-50 μM and 21nM, respectively. The nanocomposite electrode demonstrates several advantages such as simple preparation method, excellent activity in physiological conditions, low detection limit, long-term stability, and remarkable voltammetric reproducibility. As a result, it can find promising applications in blood serum and urine samples.