Update on riboflavin and multiple sclerosis: a systematic review
Authors
Abstract:
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Riboflavin plays an important role in myelin formation, and its deficiency is implicated as a risk factor for multiple sclerosis. Here, we systematically reviewed the literature concerning the health benefits of riboflavin on MS. The literature recorded within four main databases, including relevant clinical trials, experimental, and case-control studies from 1976 to 2017 were considered. Both human and animal studies were included for review, with no restrictions on age, gender, or ethnicity. Experimental studies demonstrated that riboflavin deficiency triggers neurologic abnormalities related to peripheral neuropathies such as demyelinating neuropathy. Moreover, randomized controlled trials (RCT) and case-control studies in which MS patients received riboflavin supplementation or had higher dietary riboflavin intake showed improvements in neurological motor disability. Riboflavin is a cofactor of xanthine oxidase and its deficiency exacerbates low uric acid caused by high copper levels, leading to myelin degeneration. The vitamin additionally plays a significant role in the normal functioning of glutathione reductase (GR) as an antioxidant enzyme, and conditions of riboflavin deficiency lead to oxidative damage. Riboflavin promotes the gene and protein levels of brain-derived neurotrophic factor (BDNF) in the CNS of an animal model of MS, suggesting that BDNF mediates the beneficial effect of riboflavin on neurological motor disability. Research to date generally supports the role of riboflavin in MS outcomes. However, further observational and interventional studies on human populations are warranted to validate the effects of riboflavin.
similar resources
Effects of Meat Consumption on Multiple Sclerosis: A Systematic Review and Meta-analysis
Backgrounds and Objectives: Multiple sclerosis is a common cause of neurological disabilities worldwide. Diet is a potential risk factor for the pathogenesis of multiple sclerosis and dietary intervention can be used as a prevention method for multiple sclerosis. The purpose of this study was the investigation of relationships between the type of meat consumed by the patients and multiple scle...
full textO 9: Immunomodulatory Effects of Neural Stem Cell on Multiple Sclerosis: A Systematic Review
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory demyelinating disorders of central nervous system (CNS). While the cause is unclear, the fundamental mechanism is thought to be destruction of myelin sheaths of neurons through immune system. One of the approaches being proposed in EAE therapy is neural stem cells (NSCs) trans...
full textDepression and Anxiety in Patients with Multiple Sclerosis (MS): A Systematic Review (In press)
Background: Multiple Sclerosis (MS) is considered as one of the most prevalent chronic and progressive neurological diseases that has high simultaneity with some psychological disorders such as depression and anxiety; we examined depression and anxiety in people suffering from MS in this review study. Methods: We conducted this study using a systematic review method relying on the search from...
full textEffect of Progressive Muscle Relaxation on the outcomes of Multiple Sclerosis disease: A systematic review and meta-analysis
Introduction: Multiple sclerosis (MS) is an inflammatory disease, makes damage in central nervous system. Evidence showed Progressive Muscle Relaxation (PMR) technique is one of the non-pharmacological methods used to treat MS. The purpose of the study was to determining the effect of PMR on the MS's outcomes in published papers in the field. Method: This systematic and meta-analysis study we...
full textAssociation between Tumor Necrosis Factor- α-308 G/A Polymorphism and Multiple Sclerosis: A Systematic Review and Meta-Analysis
Multiple sclerosis (MS) is a complex polygenic disease in which gene-environment interactions are important. A number of studies have investigated the association between tumor necrosis factor-α (TNF-α) -308 G/A polymorphism (substitution G→A, designated as TNF1 and TNF2) and MS susceptibility in different populations, but the results of individual studies have been inconsistent. Therefore, per...
full textMy Resources
Journal title
volume 20 issue 9
pages 958- 966
publication date 2017-09-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023