TiO2 Nanoparticles as a Common Component of Sunscreens: An Experimental Study of Dermal/Ocular Safety Assessment

Authors

  • Ali Rasooli Department of Comparative Biosciences, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
  • Ebrahim Shahroozian Department of Basic Science, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
  • Mohammad Kazem Koohi Department of Comparative Biosciences, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
  • Seyedeh Maedeh Jafari Department of Comparative Biosciences, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
Abstract:

Background: The safety evaluations of sunscreens containing Titanium Dioxide-Nanoparticles (TiO2-NPs) were done by dermal exposure, acute dermal and eye irritation/corrosion, and skin sensitization according to the guideline for Organization for Economic Co-operation and Development (OECD). OBJECTIVES: The aim of our study was the evaluation of safety and toxicity of TiO2-NPs following acute sunscreen exposure. METHODS: TiO2 and TiO2-NPs (20-40 nm and 98% purity) were purchased in the anatase crystal phase, and five types of concentration for sunscreens were made which were carried out in five different treatment groups in mice and rabbits. RESULTS: In acute eye irritation using rabbits, the only irritation effect was observed in the conjunctivae area within one hour after administration both in TiO2-NPs group and TiO2-Ps. In acute dermal irritation using rabbits did not show a significant difference among groups in different concentrations and durations. Similarly, in a skin sensitization test using mice, contact hypersensitivity (CHS) did not show a significant difference (P

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Journal title

volume 13  issue 1

pages  79- 86

publication date 2019-02-01

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