The Impact of Gender on the Inflammatory Parameters and Angiogenesis in the Rat Air Pouch Model of Inflammation

Authors

  • Moslem Najafi Department of Pharmacology and Toxicology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran|Research Center for Pharmaceutical Nanotechnology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  • Nasrin Maleki-dizaji Department of Pharmacology and Toxicology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  • Tahereh Eteraf Oskouei School of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran|Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract:

Objective(s) Air pouch is a well-established inflammatory model in which fluid extravasations; leukocyte migration, angiogenesis and other parameters involved in the inflammatory response can be measured. In this study, the influence of gender on inflammatory parameters has been examined in the air pouch model. Materials and Methods To induce air pouch, adult male and female Wistar rats were anesthetized, then 20 ml and 10 ml of sterile air were injected subcutaneously on the back on day 0 and day 3, respectively. On day 6, inflammation was induced by injection of 1 ml of carrageenan 1% into pouches. After 6 and 72 hr, the rats were sacrificed, pouch fluid was collected in order to determine exudates volume and the accumulated cells were counted using a hemocytometer. Pouches were dissected out and weighed. Angiogenesis of granulomatous tissue was assayed using hemoglobin kit. Results Analysis of our data demonstrated a sexually dimorphic pattern in inflammation parameters both in acute and chronic forms (P

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Journal title

volume 12  issue 2

pages  80- 85

publication date 2009-04-01

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