The Efficacy of Paricalcitol Administration for Management of Pediatric Chronic Kidney Disease: A Systematic Review and Meta-analysis

Authors

  • Mohammed I. M. Gubari Department of Family and Community Medicine, College of Medicine, University of Sulaimani, Sulaimani, Iraq.
  • Mojtaba Fazel Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Pediatrics, Valiasr Hospital, Imam Khomeini Medical Complex, Tehran University of Medical Sciences, Tehran, Iran.
  • Mostafa Hosseini Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Neamatollah Ataei Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Pediatrics, Valiasr Hospital, Imam Khomeini Medical Complex, Tehran University of Medical Sciences, Tehran, Iran.
  • Sorour Khari Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:

Background There is still controversy about the efficacy of paricalcitol in children with chronic kidney disease (CKD). Therefore, the present study was designed to assess current evidence on the efficacy of paricalcitol in CKD children. Materials and Methods In this systematic review, an extensive search was performed on the databases of Medline, Embase, Scopus and Web of Science up to the end of October 2019. The keywords related to CKD and paricalcitol were combined and searched. Two independent researchers reviewed the papers; data were analyzed in STATA 14.0 statistical program and the effect of paricalcitol administration on serum levels of intact parathyroid hormone (iPTH), calcium (Ca), phosphorous (P), and Ca × P product ratio were reported as odds ratio (OR), and 95% confidence interval (95%CI). Results: Finally, data from three studies were included in the present study. Paricalcitol administration decreased iPTH levels in children with CKD (OR=0.12; 95%CI: 0.05 to 0.29; p<0.001). However, paricalcitol administration had no effect on serum calcium level (OR=1.16; 95%CI: 0.48 to 2.80; p=0.741), serum phosphorus level (OR=0.87; 95%CI: 0.38 to 1.99; p=0.735), and Ca × P ratio (OR=0.48; 95% CI: 0.15 to 1.50; p=0.208). No study has investigated the efficacy of paricalcitol on the control of proteinuria following CKD. Conclusion There is limited evidence on the efficacy and safety of paricalcitol in children with CKD. There are no studies in CKD children that have shown efficacy of Paricalcitol in controlling proteinuria. 

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Efficacy of radiosynovectomy in the treatment of chronic knee synovitis: Systematic review and meta-analysis

Introduction: Knee joints are commonly involved with various inflammatory and non- inflammatory rheumatic diseases. Radiosynovectomy is being used as a local therapeutic option to alleviate pain and swelling in involved joints. The present study evaluated the effectiveness of radiosynovectomy for treatment of chronic knee synovitis. Methods: Through a search of Medline and SCOPUS with (Radiosy...

full text

The Effectiveness of a Chronic Disease Self-Management Program for Elderly People: a Systematic Review

Introduction: Elderly population is increasing in Pakistan. Majority of people aged 50 – 64, suffer from two or more chronic conditions. Care of elderly people is sub-optimal. Healthcare system has limited resources to provide healthcare support to elderly people. Thus, there is need to empower the elderly to self-manage their health conditions. Chronic Disease Self-Management Program (CDSMP) i...

full text

Effect of pentoxifylline on anemia in patients with chronic kidney disease: an updated systematic review and meta-analysis

Background: Pentoxifylline, a valuable medication with promising clinical characteristics and considerable profile of safety is used in many conditions namely chronic kidney diseases (CKD). However, the decision to prescribe pentoxifylline for anemia in CKD should be based on evidence accrued from randomized controlled trials (RCTs). Yet, substantial heterogeneity exists in studies performed to...

full text

Efficacy of Alpha-lipoic Acid in The Management of Diabetes Mellitus: A Systematic Review and Meta-analysis

Alpha-lipoic acid (ALA) is a naturally-occurring compound that has shown promising antioxidant and anti-inflammatory effects in experimental and human studies. The aim of this study was to assess the efficacy of ALA in the management of patients with diabetes mellitus (DM).We searched Medline (via PubMed), EBSCO, Scopus, and Web of Science for relevant randomized controlled trials. Data o...

full text

Efficacy of Alpha-lipoic Acid in The Management of Diabetes Mellitus: A Systematic Review and Meta-analysis

Alpha-lipoic acid (ALA) is a naturally-occurring compound that has shown promising antioxidant and anti-inflammatory effects in experimental and human studies. The aim of this study was to assess the efficacy of ALA in the management of patients with diabetes mellitus (DM).We searched Medline (via PubMed), EBSCO, Scopus, and Web of Science for relevant randomized controlled trials. Data o...

full text

Efficacy of Enema via Cecostomy for Fecal Disorders in Children: A Systematic Review and Meta-Analysis

  Background   Some controversy exists about the role of cecostomy in the management of fecal disorders. The present meta-analysis aims provide a comprehensive evaluation on the role of cecostomy on management of fecal incontinence and constipation in children.   Materials and Methods   An extensive search was performed on the Medline, Embase, Scopus, and Web of Science until July 2017. Two ind...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 8  issue 2

pages  10951- 10959

publication date 2020-02-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023