The Effect of Withania somnifera Alcoholic Extract on Learning and Memory Disturbance in a Model of Temporal Lobe Epilepsy in the Rat

Authors

  • Jamshid Narenjkar Department of Pharmacology, School of Medicine, Shahed University, Tehran, Iran.
Abstract:

Background and Objective: Temporal lobe epilepsy (TLE) usually leads to memory deficit. In this study, we tried to assess the effect of Withania somnifera extract on the impaired learning and memory in the intrahippocampal kainate model of TLE in the rat. Materials & Methods: Male rats (n=32) were divided into sham, extract+sham, kainite, and kainite+extract. For induction of epilepsy, unilateral hippocampal injection of 1 microgram of kainate was made. Rats received the extract at a dose of 100 mg/kg daily for three days prior to surgery. At the end of 4 weeks, to assess learning and memory, initial latency and step through delay using passive avoidance test and the percentage of alternation behavior in the Y maze test were determined. Results: Extract pretreatment of kainate group did not significantly attenuate severity and incidence rate of seizures, did not significantly improve retrieval and recall in passive avoidance and significantly ameliorated spatial memory deficit in Y maze (p

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

the effect of withania somnifera alcoholic extract on learning and memory disturbance in a model of temporal lobe epilepsy in the rat

background and objective: temporal lobe epilepsy (tle) usually leads to memory deficit. in this study, we tried to assess the effect of withania somnifera extract on the impaired learning and memory in the intrahippocampal kainate model of tle in the rat. materials & methods: male rats (n=32) were divided into sham, extract+sham, kainite, and kainite+extract. for induction of epilepsy, uni...

full text

The Effect of Alpha-Lipoic Acid on Learning and Memory Deficit in a Rat Model of Temporal Lobe Epilepsy

Introduction: Epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures and deficiency in learning and memory. Although the most commonly recommended therapy is drug treatment, some patients do not achieve adequate control of their seizures on existing drugs. New medications with novel mechanisms of action are needed to help those patients whose sei...

full text

the effect of learning strategies on the speaking ability of iranian students in the context of language institutes

the effect of learning strategies on the speaking ability of iranian students in the context of language institutes abstract language learning strategies are of the most important factors that help language learners to learn a foreign language and how they can deal with the four language skills specifically speaking skill effectively. acknowledging the great impact of learning strategies...

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

the washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests

در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است

15 صفحه اول

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 3  issue 1

pages  13- 18

publication date 2014-01-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023