The Effect of Transplantation of Collagen Hydrogel with Adipose-Derived Mesenchymal Stem Cells on Burn Wound Healing in Rats

Background: Cell therapy is one of the most challenging methods in the healing of burn wounds in the world. The present study aimed to determine the effect of collagen hydrogel with adipose-derived mesenchymal stem cells on burn wound healing in an animal model. Materials and Methods: The present study was experimentally performed on 24 Wistar rats. Burn wounds were created on the skin of rats. Then, the rats were divided into a control group treated with normal saline and a group treated with collagen hydrogel with adipose tissue-derived mesenchymal stem cells. The healing process of burn wounds was quantitatively and qualitatively evaluated at intervals of every seven days for 21 days. The obtained data were analyzed in the form of burn wound healing parameters using one-way ANOVA. Results: The wound area was traced on days 7, 14, and 21 in the treatment group which was significantly smaller than that in the control group, indicating a faster wound healing in the treatment group compared to the control one  (P>0/05). Conclusion: Mesenchymal stem cells transferred by hydrogel to the wound site rapidly heal burn wounds; therefore, evaluating the use of this dressing in the healing of burn wounds is important in clinical cases.