The effect of silymarin on prevention of hippocampus neuronal damage in rats with temporal lob epilepsy
Authors
Abstract:
Background and Objective: Temporal lobe epilepsy is hallmarked with neuronal degeneration in some areas of hippocampus and mossy fiber sprouting in dentate area. Considering some evidences on neuroprotective and antioxidant activity of silymarin (SM), this study was undertaken to evaluate the preventive effect of this agent on structural changes in hippocampus of kainate-epileptic rats. Materials and Methods: In this study, 32 male rats were divided into sham, SM-treated sham, epileptic, and SM-treated epileptic group. Rat model of epilepsy was induced by unilateral intrahippocampal administration of 0.8 μg kainic acid per rat. Rats received SM (100 mg/kg, i.p.) daily for 3 days before the surgery. Finally, brain sections were stained with Nissl and Timm methods. Results: Induction of epilepsy was followed by a significant seizure and SM pretreatment did not lower seizure intensity. In addition, density of Nissl-stained neurons in CA3 and CA4 areas of hippocampus was significantly lower in epileptic rats versus sham (p
similar resources
the effect of silymarin on prevention of hippocampus neuronal damage in rats with temporal lob epilepsy
background and objective: temporal lobe epilepsy is hallmarked with neuronal degeneration in some areas of hippocampus and mossy fiber sprouting in dentate area. considering some evidences on neuroprotective and antioxidant activity of silymarin (sm), this study was undertaken to evaluate the preventive effect of this agent on structural changes in hippocampus of kainate-epileptic rats. materia...
full textthe effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولthe washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests
در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است
15 صفحه اولthe effect of taftan pozzolan on the compressive strength of concrete in the environmental conditions of oman sea (chabahar port)
cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...
the effect of e-64 on the developmental competence of sheep cocs during in vitro maturation
in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.
the effect of learning strategies on the speaking ability of iranian students in the context of language institutes
the effect of learning strategies on the speaking ability of iranian students in the context of language institutes abstract language learning strategies are of the most important factors that help language learners to learn a foreign language and how they can deal with the four language skills specifically speaking skill effectively. acknowledging the great impact of learning strategies...
My Resources
Journal title
volume 5 issue 1
pages 45- 50
publication date 2017-03-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023